1QLF: Mhc Class I H-2db Complexed With Glycopeptide K3g

Citation:
Abstract
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.
PDB ID: 1QLFDownload
MMDB ID: 11233
PDB Deposition Date: 1999/8/30
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.65  Å
Source Organism:
Murine respirovirus
Similar Structures:
Biological Unit for 1QLF: trimeric; determined by software (PQS)
Molecular Components in 1QLF
Label Count Molecule
Proteins (3 molecules)
1
MHC Class I H-2db Heavy Chain(Gene symbol: H2-D1)
Molecule annotation
1
Human Beta-2-microglobulin
Molecule annotation
1
Synthetic Glycopeptide
Molecule annotation
Chemicals (4 molecules)
1
2
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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