1QHI: Herpes Simplex Virus Type-i Thymidine Kinase Complexed With A Novel Non-substrate Inhibitor, 9-(4-hydroxybutyl)-n2- Phenylguanine

Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.
PDB ID: 1QHIDownload
MMDB ID: 10922
PDB Deposition Date: 1999/5/12
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 1QHI: dimeric; determined by author and by software (PISA)
Molecular Components in 1QHI
Label Count Molecule
Proteins (2 molecules)
Protein (Thymidine Kinase)
Molecule annotation
Chemicals (4 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB