1QGT: Human Hepatitis B Viral Capsid (hbcag)

Citation:
Abstract
Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface.
PDB ID: 1QGTDownload
MMDB ID: 10576
PDB Deposition Date: 1999/5/5
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 1QGT: 240-meric
Molecular Components in 1QGT
Label Count Molecule
Proteins (240 molecules)
240
Protein (Hbv Capsid Protein)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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