1QA6: Crystal Structure Of A Conserved Ribosomal Protein-Rna Complex

The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.
PDB ID: 1QA6Download
MMDB ID: 10294
PDB Deposition Date: 1999/4/15
Updated in MMDB: 1999/11
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Enterobacter cloacae subsp. cloacae ENHKU01
Similar Structures:
Biological Unit for 1QA6: dimeric; determined by author
Molecular Components in 1QA6
Label Count Molecule
Protein (1 molecule)
Ribosomal Protein L11
Molecule annotation
Nucleotide(1 molecule)
58 Nucleotide Ribosomal RNA Domain
Molecule annotation
Chemicals (3 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB