1PXH: Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2

PDB ID: 1PXHDownload
MMDB ID: 24170
PDB Deposition Date: 2003/7/4
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 1PXH: monomeric; determined by author
Molecular Components in 1PXH
Label Count Molecule
Protein (1 molecule)
1
Protein-tyrosine Phosphatase, Non-receptor Type 1
(Gene symbol: PTPN1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
1
N-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACIDN-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACID
3
2
ACETIC ACIDACETIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303