1PWU: Crystal Structure Of Anthrax Lethal Factor Complexed With (3-(n-hydroxycarboxamido)-2-isobutylpropanoyl-trp- Methylamide), A Known Small Molecule Inhibitor Of Matrix Metalloproteases

Recent events have created an urgent need for new therapeutic strategies to treat anthrax. We have applied a mixture-based peptide library approach to rapidly determine the optimal peptide substrate for the anthrax lethal factor (LF), a metalloproteinase with an important role in the pathogenesis of the disease. Using this approach we have identified peptide analogs that inhibit the enzyme in vitro and that protect cultured macrophages from LF-mediated cytolysis. The crystal structures of LF bound to an optimized peptide substrate and to peptide-based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors.
PDB ID: 1PWUDownload
MMDB ID: 26096
PDB Deposition Date: 2003/7/2
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 1PWU: monomeric; determined by author
Molecular Components in 1PWU
Label Count Molecule
Protein (1 molecule)
Lethal Factor(Gene symbol: pxo1_107)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB