1PL0: Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC

PDB ID: 1PL0Download
MMDB ID: 27262
PDB Deposition Date: 2003/6/6
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 1PL0: dimeric; determined by author and by software (PISA)
Molecular Components in 1PL0
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Purine Biosynthesis Protein Purh
(Gene symbol: ATIC)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
POTASSIUM IONPOTASSIUM ION
2
1
XANTHOSINE-5'-MONOPHOSPHATEXANTHOSINE-5'-MONOPHOSPHATE
3
1
AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDEAMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
4
1
N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACIDN-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303