1PDG: CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB

Citation:
Abstract
The crystal structure of the homodimeric BB isoform of human recombinant platelet-derived growth factor (PDGF-BB) has been determined by X-ray analysis to 3.0 A resolution. The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds. Dimerization leads to the clustering of three surface loops at each end of the elongated dimer, which most probably form the receptor recognition sites.
PDB ID: 1PDGDownload
MMDB ID: 50784
PDB Deposition Date: 1992/7/14
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 1PDG: dimeric; determined by author and by software (PISA)
Molecular Components in 1PDG
Label Count Molecule
Proteins (2 molecules)
2
Platelet-derived Growth Factor BB(Gene symbol: PDGFB)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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