1OZ3: Crystal Structure Of 3-Mbt Repeats Of Lethal (3) Malignant Brain Tumor (Native-I) At 1.85 Angstrom

Citation:
Abstract
We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket.
PDB ID: 1OZ3Download
MMDB ID: 24097
PDB Deposition Date: 2003/4/7
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 1OZ3: nonameric; determined by author
Molecular Components in 1OZ3
Label Count Molecule
Proteins (9 molecules)
9
Lethal(3)malignant Brain Tumor-like Protein(Gene symbol: L3MBTL1)
Molecule annotation
Chemicals (48 molecules)
1
30
2
18
* Click molecule labels to explore molecular sequence information.

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