1OKE: Crystal Structure Of The Dengue 2 Virus Envelope Protein In Complex With N-Octyl-Beta-D-Glucoside

Citation:
Abstract
Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.
PDB ID: 1OKEDownload
MMDB ID: 24349
PDB Deposition Date: 2003/7/22
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 1OKE: dimeric; determined by author and by software (PISA)
Molecular Components in 1OKE
Label Count Molecule
Proteins (2 molecules)
2
Major Envelope Protein E
Molecule annotation
Chemicals (12 molecules)
1
6
2
2
3
2
4
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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