1OK3: Decay Accelerating Factor (cd55): The Structure Of An Intact Human Complement Regulator

Citation:
Abstract
The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis. X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement of four short consensus repeat (SCR) domains in both the crystal and solution. The stalk linking the four SCR domains to the glycosylphosphatidylinositol anchor is extended by the addition of 11 highly charged O-glycans and positions the domains an estimated 177 A above the membrane. Mutation mapping and hydrophobic potential analysis suggest that the interaction with the convertase, and thus complement regulation, depends on the burial of a hydrophobic patch centered on the linker between SCR domains 2 and 3.
PDB ID: 1OK3Download
MMDB ID: 26045
PDB Deposition Date: 2003/7/16
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 1OK3: dimeric; determined by author and by software (PQS)
Molecular Components in 1OK3
Label Count Molecule
Proteins (2 molecules)
2
Complement Decay-accelerating Factor(Gene symbol: CD55)
Molecule annotation
Chemicals (15 molecules)
1
4
2
2
3
9
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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