1OD1: Endothiapepsin Pd135,040 Complex

Citation:
Abstract
The crystal structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 has been anisotropically refined to a resolution of 1.37 A. The structure of this inhibitor complex is in agreement with previous structures of endothiapepsin gem-diol inhibitor complexes that have been used to develop proposed catalytic mechanisms. However, the increase in resolution over previous structures confirms the presence of a number of short hydrogen bonds within the active site that are likely to play an important role in the catalytic mechanism. The presence of low-barrier hydrogen bonds was indicated in a previous one-dimensional H NMR spectrum.
PDB ID: 1OD1Download
MMDB ID: 102288
PDB Deposition Date: 2003/2/12
Updated in MMDB: 2012/08
Experimental Method:
x-ray diffraction
Resolution: 1.37  Å
Source Organism:
Similar Structures:
Biological Unit for 1OD1: monomeric; determined by author and by software (PQS)
Molecular Components in 1OD1
Label Count Molecule
Protein (1 molecule)
1
Endothiapepsin
Molecule annotation
Chemicals (3 molecules)
1
1
2
2
* Click molecule labels to explore molecular sequence information.

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