1NZQ: D-Phe-Pro-Arg-Type Thrombin Inhibitor

Citation:
Abstract
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.
PDB ID: 1NZQDownload
MMDB ID: 24978
PDB Deposition Date: 2003/2/19
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.18  Å
Source Organism:
Homo sapiens
Similar Structures:
Biological Unit for 1NZQ: trimeric; determined by author and by software (PISA)
Molecular Components in 1NZQ
Label Count Molecule
Proteins (3 molecules)
1
Thrombin Light Chain(Gene symbol: F2)
Molecule annotation
1
Thrombin Heavy Chain(Gene symbol: F2)
Molecule annotation
1
Decapeptide Hirudin Analogue
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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