National Center for
1NZQ: D-Phe-Pro-Arg-Type Thrombin Inhibitor
Bioorg. Med. Chem. Lett. (2003) 13 p.2029-2033
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.