1NP0: Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline

PDB ID: 1NP0Download
MMDB ID: 153819
PDB Deposition Date: 2003/1/16
Updated in MMDB: 2023/08
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1NP0: hexameric; determined by author and by software (PISA)
Molecular Components in 1NP0
Label Count Molecule
Proteins (6 molecules)
2
Beta-hexosaminidase Subunit Beta
(Gene symbol: HEXB)
Molecule annotation
2
Beta-hexosaminidase Subunit Beta Chain B
(Gene symbol: HEXB)
Molecule annotation
2
Beta-hexosaminidase Subunit Beta Chain a
(Gene symbol: HEXB)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
5
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL
3
4
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303