1NCH: Structural Basis Of Cell-Cell Adhesion By Cadherins

Citation:
Abstract
Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.
PDB ID: 1NCHDownload
MMDB ID: 3476
PDB Deposition Date: 1995/3/23
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 1NCH: dimeric; determined by author
Molecular Components in 1NCH
Label Count Molecule
Proteins (2 molecules)
2
N-cadherin(Gene symbol: Cdh2)
Molecule annotation
Chemicals (2 molecules)
1
2
* Click molecule labels to explore molecular sequence information.

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