1N4X: Structure Of Scfv 1696 At Acidic Ph

The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in the non-complexed form, solved at 1.7 A resolution, is compared with the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures.
PDB ID: 1N4XDownload
MMDB ID: 23422
PDB Deposition Date: 2002/11/2
Updated in MMDB: 2012/12
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 1N4X: dimeric; determined by author and by software (PISA)
Molecular Components in 1N4X
Label Count Molecule
Proteins (2 molecules)
Immunoglobulin Kappa Chain Variable Region
Molecule annotation
Immunoglobulin Heavy Chain Variable Region
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

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