1M6B: Structure Of The Her3 (Erbb3) Extracellular Domain

We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.
PDB ID: 1M6BDownload
MMDB ID: 20305
PDB Deposition Date: 2002/7/15
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 1M6B: monomeric; determined by author
Molecular Components in 1M6B
Label Count Molecule
Protein (1 molecule)
Receptor Protein-tyrosine Kinase Erbb-3(Gene symbol: ERBB3)
Molecule annotation
Chemicals (8 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB