1M51: Pepck Complex With A Gtp-Competitive Inhibitor

Citation:
Abstract
The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented.
PDB ID: 1M51Download
MMDB ID: 24602
PDB Deposition Date: 2002/7/6
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.25  Å
Source Organism:
Similar Structures:
Biological Unit for 1M51: monomeric; determined by author
Molecular Components in 1M51
Label Count Molecule
Protein (1 molecule)
1
Phosphoenolpyruvate Carboxykinase, Cytosolic(Gene symbol: PCK1)
Molecule annotation
Chemicals (5 molecules)
1
1
2
1
3
1
4
2
* Click molecule labels to explore molecular sequence information.

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