1M24: Trichotoxin_a50e, An Ion Channel-forming Polypeptide

Citation:
Abstract
Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
PDB ID: 1M24Download
MMDB ID: 93053
PDB Deposition Date: 2002/6/21
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 0.9  Å
Biological Unit for 1M24: dimeric; determined by author
Molecular Components in 1M24
Label Count Molecule
Nucleotide(1 molecule)
2
Trichotoxin_a50e
Molecule annotation
Chemicals (2 molecules)
1
2
* Click molecule labels to explore molecular sequence information.

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