1KMX: Heparin-binding Domain from Vascular Endothelial Growth Factor

Previous NMR structural studies of the heparin-binding domain of vascular endothelial growth factor (VEGF165) revealed a novel fold comprising two subdomains, each containing two disulfide bridges and a short two-stranded antiparallel beta-sheet. The mutual orientation of the two subdomains was poorly defined by the NMR data. Heteronuclear relaxation data suggested that this disorder resulted from a relative lack of experimental restraints due to the limited size of the interface, rather than inherent high-frequency flexibility. Refinement of the structure using 1H(N-15N residual dipolar coupling restraints results in significantly improved definition of the relative subdomain orientations.
PDB ID: 1KMXDownload
MMDB ID: 20170
PDB Deposition Date: 2001/12/17
Updated in MMDB: 2007/10
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 1KMX
Label Count Molecule
Protein (1 molecule)
Vascular Endothelial Growth Factor(Gene symbol: VEGFA)
Molecule annotation
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Citing MMDB