1K9J: Complex Of Dc-signr And Glcnac2man3

Citation:
Abstract
Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.
PDB ID: 1K9JDownload
MMDB ID: 18321
PDB Deposition Date: 2001/10/29
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 1K9J: dimeric; determined by author
Molecular Components in 1K9J
Label Count Molecule
Proteins (2 molecules)
2
Mdc-sign2 Type I Isoform(Gene symbol: CLEC4M)
Molecule annotation
Chemicals (8 molecules)
1
2
2
3
3
3
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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