1JNP: Crystal Structure of Murine Tcl1 at 2.5 Resolution

Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
PDB ID: 1JNPDownload
MMDB ID: 17573
PDB Deposition Date: 2001/7/24
Updated in MMDB: 2007/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1JNP: dimeric; determined by author
Molecular Components in 1JNP
Label Count Molecule
Proteins (2 molecules)
T-cell Leukemia/lymphoma Protein 1A(Gene symbol: Tcl1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB