1IEN: SOLUTION STRUCTURE OF TIA

Citation:
Abstract
Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.
PDB ID: 1IENDownload
MMDB ID: 73673
PDB Deposition Date: 2001/4/10
Updated in MMDB: 2009/07
Experimental Method:
solution nmr
Similar Structures:
Molecular Components in 1IEN
Label Count Molecule
Protein (1 molecule)
1
Protein TIA
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.