1GXJ: SMC hinge domain from T. maritima w/o coiled coil

Sister chromatids are held together by the multisubunit cohesin complex, which contains two SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3) proteins. The crystal structure of a bacterial SMC "hinge" region along with EM studies and biochemical experiments on yeast Smc1 and Smc3 proteins show that SMC protamers fold up individually into rod-shaped molecules. A 45 nm long intramolecular coiled coil separates the hinge region from the ATPase-containing "head" domain. Smc1 and Smc3 bind to each other via heterotypic interactions between their hinges to form a V-shaped heterodimer. The two heads of the V-shaped dimer are connected by different ends of the cleavable Scc1 subunit. Cohesin therefore forms a large proteinaceous loop within which sister chromatids might be entrapped after DNA replication.
PDB ID: 1GXJDownload
MMDB ID: 49359
PDB Deposition Date: 2002/4/7
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1GXJ: dimeric; determined by author and by software (PQS)
Molecular Components in 1GXJ
Label Count Molecule
Proteins (2 molecules)
Chromosome Segregation SMC Protein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB