1G4K: X-ray Structure Of A Novel Matrix Metalloproteinase Inhibitor Complexed To Stromelysin

Citation:
Abstract
A new class of matrix metalloproteinase (MMP) inhibitors has been identified by screening a collection of compounds against stromelysin. The inhibitors, 2,4,6-pyrimidine triones, have proven to be potent inhibitors of gelatinases A and B. An X-ray crystal structure of one representative compound bound to the catalytic domain of stromelysin shows that the compounds bind at the active site and ligand the active-site zinc. The pyrimidine triones mimic substrates in forming hydrogen bonds to key residues in the active site, and provide opportunities for placing appropriately chosen groups into the S1' specificity pocket of MMPS: A number of compounds have been synthesized and assayed against stromelysin, and the variations in potency are explained in terms of the binding mode revealed in the X-ray crystal structure.
PDB ID: 1G4KDownload
MMDB ID: 16211
PDB Deposition Date: 2000/10/27
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1G4K: monomeric; determined by author
Molecular Components in 1G4K
Label Count Molecule
Protein (1 molecule)
1
Stromelysin-1(Gene symbol: MMP3)
Molecule annotation
Chemicals (7 molecules)
1
2
2
3
3
2
* Click molecule labels to explore molecular sequence information.

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