1FZO: Mhc Class I Natural Mutant H-2kbm8 Heavy Chain Complexed With Beta-2 Microglobulin And Sendai Virus Nucleoprotein

Citation:
Abstract
The K(bm1) and K(bm8) natural mutants of the murine MHC class I molecule H-2K(b) were originally identified by allograft rejection. They also bind viral peptides VSV8 and SEV9 with high affinity, but their peptide complexes have substantially decreased thermostability, and the K(bm1) complexes do not elicit alloreactive T cell responses. Crystal structures of the four mutant complexes at 1.7-1.9 A resolution are similar to the corresponding wild-type K(b) structures, except in the vicinity of the mutated residues, which alter the electrostatic potential, topology, hydrogen bonding, and local water structure of the peptide binding groove. Thus, these natural K(b) mutations define the minimal perturbations in the peptide environment that alter antigen presentation to T cells and abolish alloreactivity.
PDB ID: 1FZODownload
MMDB ID: 49180
PDB Deposition Date: 2000/10/3
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Mus musculus
Similar Structures:
Biological Unit for 1FZO: trimeric; determined by author and by software (PISA)
Molecular Components in 1FZO
Label Count Molecule
Proteins (3 molecules)
1
H-2 Class I Histocompatibility Antigen, K-B Alpha Chain(Gene symbol: H2-K1)
Molecule annotation
1
Protein (Beta-2-microglobulin)
Molecule annotation
1
Protein (Nucleocapsid Protein)
Molecule annotation
Chemicals (7 molecules)
1
2
2
1
3
1
4
2
5
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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