1ED6: Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed With L- Nio (H4b Free)

Citation:
Abstract
The crystal structure of the endothelial nitric oxide synthase (NOS) heme domain complexed with NO reveals close hydrogen bonding interactions between NO and the terminal guanidino nitrogen of the substrate, L-arginine. Dioxygen is expected to bind in a similar mode which will facilitate proton abstraction from L-Arg to dioxygen, a required step for O-O bond cleavage. Structures of mechanism-based NOS inhibitors, N(5)-(1-iminoethyl)-L-ornithine and N-(3-(aminomethyl)benzyl)acetamidine, provide clues on how this class of compounds operate as suicide substrate inhibitors leading to heme oxidation.
PDB ID: 1ED6Download
MMDB ID: 15278
PDB Deposition Date: 2000/1/26
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 1ED6: dimeric; determined by author and by software (PISA)
Molecular Components in 1ED6
Label Count Molecule
Proteins (2 molecules)
2
Nitric Oxide Synthase(Gene symbol: NOS3)
Molecule annotation
Chemicals (11 molecules)
1
2
2
1
3
2
4
2
5
2
6
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.