1E7W: One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes

PDB ID: 1E7WDownload
MMDB ID: 71059
PDB Deposition Date: 2000/9/11
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 1E7W: tetrameric; determined by author and by software (PQS)
Molecular Components in 1E7W
Label Count Molecule
Proteins (4 molecules)
4
Pteridine Reductase
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
4
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
4
METHOTREXATEMETHOTREXATE
3
6
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303