1CKL: N-Terminal Two Domains Of Human Cd46 (Membrane Cofactor Protein, Mcp)

Citation:
Abstract
Measles virus is a paramyxovirus which, like other members of the family such as respiratory syncytial virus, is a major cause of morbidity and mortality worldwide. The cell surface receptor for measles virus in humans is CD46, a complement cofactor. We report here the crystal structure at 3.1 A resolution of the measles virus-binding fragment of CD46. The structure reveals the architecture and spatial arrangement of two glycosylated short consensus repeats with a pronounced interdomain bend and some flexibility at the domain interface. Amino acids involved in measles virus binding define a large, glycan-free surface that extends from the top of the first to the bottom of the second repeat. The extended virus-binding surface of CD46 differs strikingly from those reported for the human virus receptor proteins CD4 and intercellular cell adhesion molecule-1 (ICAM-1), suggesting that the CD46 structure utilizes a novel mode of virus recognition. A highly hydrophobic and protruding loop at the base of the first repeat bears a critical virus-binding residue, thereby defining an important recognition epitope. Molecules that mimic the conformation of this loop potentially could be effective anti-viral agents by preventing binding of measles virus to CD46.
PDB ID: 1CKLDownload
MMDB ID: 10509
PDB Deposition Date: 1999/4/22
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 1CKL: monomeric; determined by author
Molecular Components in 1CKL
Label Count Molecule
Protein (1 molecule)
1
Protein (Cd46)(Gene symbol: CD46)
Molecule annotation
Chemicals (7 molecules)
1
5
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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