1CK7: GELATINASE A (FULL-LENGTH)

Citation:
Abstract
Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.
PDB ID: 1CK7Download
MMDB ID: 10832
PDB Deposition Date: 1999/4/28
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 1CK7: monomeric; determined by author
Molecular Components in 1CK7
Label Count Molecule
Protein (1 molecule)
1
Protein (Gelatinase A)(Gene symbol: MMP2)
Molecule annotation
Chemicals (9 molecules)
1
2
2
3
3
1
4
1
5
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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