1CJ1: Growth Factor Receptor Binding Protein Sh2 Domain (human) Complexed With A Phosphotyrosyl Derivative

Previous efforts in the search for molecules capable of blocking the associations between the activated tyrosine kinase growth factor receptors and the SH2 domain of Grb2 had resulted in the identification of 3-amino-Z-pTyr-Ac6c-Asn-NH2, a high-affinity and selective antagonist of this SH2 domain. In the present paper, we report the successful replacement of asparagine in this compound by a beta-amino acid mimetic, which brings us closer to our objective of identifying a Grb2-SH2 antagonist suitable for pharmacological investigations.
PDB ID: 1CJ1Download
MMDB ID: 13088
PDB Deposition Date: 1999/4/21
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 1CJ1: dimeric; determined by author and by software (PISA)
Molecular Components in 1CJ1
Label Count Molecule
Proteins (2 molecules)
Protein (Growth Factor Receptor-bound Protein 2)(Gene symbol: GRB2)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB