1CD9: 2:2 Complex Of G-Csf With Its Receptor

Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
PDB ID: 1CD9Download
MMDB ID: 12574
PDB Deposition Date: 1999/3/8
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Mus musculus
Similar Structures:
Biological Unit for 1CD9: tetrameric; determined by author
Molecular Components in 1CD9
Label Count Molecule
Proteins (4 molecules)
Protein (Granulocyte Colony-stimulating Factor)(Gene symbol: CSF3)
Molecule annotation
Protein (G-csf Receptor)(Gene symbol: Csf3r)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB