1C6Z: Alternate Binding Site For The P1-P3 Group Of A Class Of Potent Hiv-1 Protease Inhibitors As A Result Of Concerted Structural Change In 80's Loop

PDB ID: 1C6ZDownload
MMDB ID: 14953
PDB Deposition Date: 1999/12/28
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1C6Z: dimeric; determined by author and by software (PISA)
Molecular Components in 1C6Z
Label Count Molecule
Proteins (2 molecules)
2
Protein (Protease)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2s)-N-[(2s,3r)-4-[(2s,3s,4as,8as)-3-(Tert-Butylcarbamoyl)-3,4,4a,5,6,7,8,8a-Octahydro-1h-Isoquinolin-2-Yl]-3-Hydroxy-1-Phenyl-Butan-2-Yl]-2-(Quinolin-2-Ylcarbonylamino)butanediamideFortovase; Saquinavir,ro 31-8959
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303