1C6X: Alternate Binding Site For The P1-P3 Group Of A Class Of Potent Hiv-1 Protease Inhibitors As A Result Of Concerted Structural Change In 80's Loop

PDB ID: 1C6XDownload
MMDB ID: 14951
PDB Deposition Date: 1999/12/28
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1C6X: dimeric; determined by author and by software (PISA)
Molecular Components in 1C6X
Label Count Molecule
Proteins (2 molecules)
2
Protein (Protease)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[2(s)-cyclopentyl-1(r)-hydroxy-3(r)methyl]-5-[(2(s)-tertiary-butylamino-carbonyl)-4-(n1-(2)-(n-methylpiperazinyl)-3-chloro-pyrazinyl-5-carbonyl)-piperazino]-4(s)-hydroxy-2(r)-phenylmethyl-pentanamideN-[2(s)-cyclopentyl-1(r)-hydroxy-3(r)methyl]-5-[(2(s)-tertiary-butylamino-carbonyl)-4-(n1-(2)-(n-methylpiperazinyl)-3-chloro-pyrazinyl-5-carbonyl)-piperazino]-4(s)-hydroxy-2(r)-phenylmethyl-pentanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303