1BY2: Structure Of M2bp Scavenger Receptor Cysteine-rich Domain

Citation:
Abstract
Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell surface molecules and in some secreted proteins, where they are thought to mediate ligand binding. We have determined the crystal structure at 2.0 A resolution of the SRCR domain of Mac-2 binding protein (M2BP), a tumor-associated antigen and matrix protein. The structure reveals a curved six-stranded beta-sheet cradling an alpha-helix. Structure-based sequence alignment demonstrates that the M2BP SRCR domain is a valid template for the entire SRCR protein superfamily. This allows an interpretation of previous mutagenesis data on ligand binding to the lymphocyte receptor CD6.
PDB ID: 1BY2Download
MMDB ID: 55680
PDB Deposition Date: 1998/10/23
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1BY2: monomeric; determined by author
Molecular Components in 1BY2
Label Count Molecule
Protein (1 molecule)
1
Mac-2 Binding Protein(Gene symbol: LGALS3BP)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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