1B03: SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE

Citation:
Abstract
The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
PDB ID: 1B03Download
MMDB ID: 12264
PDB Deposition Date: 1998/11/17
Updated in MMDB: 2017/12
Experimental Method:
solution nmr
Similar Structures:
Biological Unit for 1B03: monomeric; determined by author
Molecular Components in 1B03
Label Count Molecule
Protein (1 molecule)
1
Protein (P1053 Peptide)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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