176D: Nmr Solution Structure Of A Peptide Nucleic Acid Complexed With Rna

Citation:
Abstract
Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
PDB ID: 176DDownload
MMDB ID: 47659
PDB Deposition Date: 1994/5/17
Updated in MMDB: 2011/10
Experimental Method:
solution nmr
Source Organism:
Biological Unit for 176D: dimeric; determined by author
Molecular Components in 176D
Label Count Molecule
Nucleotides(2 molecules)
1
DNA (5'-d(*gpn*apn*apn*cpn*tpn*cpn)-3')
Molecule annotation
1
RNA (5'-r(p*gp*ap*gp*up*up*c)-3')
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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