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6MX8:
Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib
PDB ID:
6MX8
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MMDB ID:
169593
PDB Deposition Date:
2018/10/30
Updated in MMDB:
2018/12
Experimental Method:
x-ray diffraction
Resolution:
1.96 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6MX8: monomeric; determined by author and by software (PISA)
Molecular Components in 6MX8
Label
Count
Molecule
Protein (1 molecule)
A
1
ALK Tyrosine Kinase Receptor
(Gene symbol:
ALK
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303