6D5E: Ras:SOS:Ras in complex with a small molecule activator

PDB ID: 6D5EDownload
MMDB ID: 166758
PDB Deposition Date: 2018/4/19
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 6D5E: trimeric; determined by author and by software (PISA)
Molecular Components in 6D5E
Label Count Molecule
Proteins (3 molecules)
1
Gtpase Hras
(Gene symbol: HRAS)
Molecule annotation
1
SON of Sevenless Homolog 1
(Gene symbol: SOS1)
Molecule annotation
1
Gtpase Hras
(Gene symbol: HRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
2
1
MAGNESIUM IONMAGNESIUM ION
3
4
CHLORIDE IONCHLORIDE ION
4
1
1-[(2S)-1-{6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazol-4-yl}pyrrolidin-2-yl]methanamine1-[(2S)-1-{6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazol-4-yl}pyrrolidin-2-yl]methanamine
5
6
FORMIC ACIDFORMIC ACID
6
3
GLYCEROLGLYCEROL
7
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303