3S3N: Crystal Structure of the Prototype Foamy Virus (Pfv) S217h Mutant Intasome in Complex With Magnesium and Dolutegravir (Sgsk1349572)

PDB ID: 3S3NDownload
MMDB ID: 91580
PDB Deposition Date: 2011/5/18
Updated in MMDB: 10/2011 
Experimental Method:
X-Ray Diffraction
Resolution: 2.49  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit: octameric; determined by author, and by software (PISA)
Molecules and interactions
Label Count Molecule Interactions
Proteins and interactions (4 molecules)
4
PFV Integrase
Show annotation
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • 5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
    *cp*a)-17 3'
  • Ammonium Ion
  • Dolutegravir
  • Glycerin
  • Magnesium Ion
  • PFV Integrase
  • Sulfate Ion
  • Zinc Ion
Nucleotides and interactions (4 molecules)
2
5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
*cp*gp*cp10 *a)-3'
  • 5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
    *cp*a)-17 3'
  • Ammonium Ion
  • Dolutegravir
  • PFV Integrase
  • Sulfate Ion
2
5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
*cp*a)-17 3'
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • Dolutegravir
  • PFV Integrase
Chemicals and interactions (24 molecules)
 -Click for PubChem compound information. 2
  • PFV Integrase
 -Click for PubChem compound information. 6
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • PFV Integrase
 -Click for PubChem compound information. 8
  • PFV Integrase
 -Click for PubChem compound information. 2
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • PFV Integrase
 -Click for PubChem compound information. 4
  • Dolutegravir
  • Magnesium Ion
  • PFV Integrase
 -Click for PubChem compound information. 2
  • 5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp
    *cp*gp*cp10 *a)-3'
  • 5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap
    *cp*a)-17 3'
  • Magnesium Ion
  • PFV Integrase
* Click molecule labels to explore molecular sequence information.

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