1JK8: Crystal Structure of a Human Insulin Peptide-hla-dq8 Complex

Citation:
Abstract
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.
PDB ID: 1JK8Download
MMDB ID: 17145
PDB Deposition Date: 2001/7/11
Updated in MMDB: 2012/11 
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 1JK8: trimeric; determined by author and by software (PISA)
Molecular Components in 1JK8
Label Count Molecule
Proteins (3 molecules)
1
MHC Class II Hla-dq8
Molecule annotation
1
MHC Class II Hla-dq8
Molecule annotation
1
Insulin B Peptide
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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