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Conserved domains on  [gi|73957241|ref|XP_851673|]
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phosphatidylcholine-sterol acyltransferase isoform X2 [Canis lupus familiaris]

Protein Classification

LCAT domain-containing protein( domain architecture ID 11131495)

LCAT domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
81-406 8.70e-153

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


:

Pssm-ID: 396835  Cd Length: 383  Bit Score: 438.14  E-value: 8.70e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241    81 TIWLDLNMFLPLGVDCWIDNTRVVYNRSSGRVSNAPGVEIRVP-GFgktYSVEYLDNNKLAGY--MHTLVQNLVNNGYVR 157
Cdd:pfam02450   1 RIWLDLNMLLPLVVDCWIDNTHVVLNPSTGLQPDPPGVKIRAAqGF---ESVEYLDYSKLAGYwiWHKVVQNLVNIGYER 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   158 DETVRAAPYDWRLEPSQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLR-QPQAWKDHFIDGFISLGAPWG 236
Cdd:pfam02450  78 NKTVRAAPYDWRLSLEERDKYFHKLKQLIEEAHKLYGKKVVLIGHSMGNLLVLYFLLWvVAEAWKDQHIDAFISLGAPLL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   237 GSIKPMLVLASGDNQGIPIMSSIKLREEQRITTTSPWMFPSRE-------AWPEDHVFISTPSFNYTGRDFQRFFAD--- 306
Cdd:pfam02450 158 GSPKAVRALASGYNFGIPILSEITLRGLQRSFSSSPWMLPKGKyvlwsdvAWPSDEIFIQTPSINYTYGALVRFFDDeti 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   307 --------LHFEEGWYMWLQSRDLLAGLP------------------------APGVEVYCLYGVGLPTPRTYIFDHG-- 352
Cdd:pfam02450 238 nvdalgftLNTLDGWYMWKVSRDLDGGLPyleaelakndikywvnpeetplpvAPGVKVYCIYGVGLPTERGYYYTPGkt 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 73957241   353 -------FPYTDPVGVLYEDGDDTVATRSTELCARWQS-RQPQPVHLLPL----HGTEHLNMVFSN 406
Cdd:pfam02450 318 sspilsrIDYEDPVGIVSGDGDGTVPKRSLELCKNWQGlPAGQNVTVHELkhgsRSAEHVDILGSN 383
 
Name Accession Description Interval E-value
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
81-406 8.70e-153

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


Pssm-ID: 396835  Cd Length: 383  Bit Score: 438.14  E-value: 8.70e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241    81 TIWLDLNMFLPLGVDCWIDNTRVVYNRSSGRVSNAPGVEIRVP-GFgktYSVEYLDNNKLAGY--MHTLVQNLVNNGYVR 157
Cdd:pfam02450   1 RIWLDLNMLLPLVVDCWIDNTHVVLNPSTGLQPDPPGVKIRAAqGF---ESVEYLDYSKLAGYwiWHKVVQNLVNIGYER 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   158 DETVRAAPYDWRLEPSQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLR-QPQAWKDHFIDGFISLGAPWG 236
Cdd:pfam02450  78 NKTVRAAPYDWRLSLEERDKYFHKLKQLIEEAHKLYGKKVVLIGHSMGNLLVLYFLLWvVAEAWKDQHIDAFISLGAPLL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   237 GSIKPMLVLASGDNQGIPIMSSIKLREEQRITTTSPWMFPSRE-------AWPEDHVFISTPSFNYTGRDFQRFFAD--- 306
Cdd:pfam02450 158 GSPKAVRALASGYNFGIPILSEITLRGLQRSFSSSPWMLPKGKyvlwsdvAWPSDEIFIQTPSINYTYGALVRFFDDeti 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   307 --------LHFEEGWYMWLQSRDLLAGLP------------------------APGVEVYCLYGVGLPTPRTYIFDHG-- 352
Cdd:pfam02450 238 nvdalgftLNTLDGWYMWKVSRDLDGGLPyleaelakndikywvnpeetplpvAPGVKVYCIYGVGLPTERGYYYTPGkt 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 73957241   353 -------FPYTDPVGVLYEDGDDTVATRSTELCARWQS-RQPQPVHLLPL----HGTEHLNMVFSN 406
Cdd:pfam02450 318 sspilsrIDYEDPVGIVSGDGDGTVPKRSLELCKNWQGlPAGQNVTVHELkhgsRSAEHVDILGSN 383
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
46-237 1.34e-06

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 50.40  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   46 PVILVPGCLGNQLEAKLDKpdvvnwmcyRKTEEffTIWLDLnmflpLGVD------CWidntrVVYNRSSGR-VSNAPGV 118
Cdd:PLN02733  21 PVLLVPGIGGSILNAVDKD---------GGNEE--RVWVRI-----FAADhefrkkLW-----SRYDPKTGKtVSLDPKT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241  119 EIRVPG--FGkTYSVEYLDNNKLAG-----YMHTLVQNLVNNGYVRDETVRAAPYDWRlEPSQQEEYYRKLAGLVEEMH- 190
Cdd:PLN02733  80 EIVVPDdrYG-LYAIDILDPDVIIRldevyYFHDMIEQLIKWGYKEGKTLFGFGYDFR-QSNRLPETMDGLKKKLETVYk 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 73957241  191 AAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDHfIDGFISLGAPWGG 237
Cdd:PLN02733 158 ASGGKKVNIISHSMGGLLVKCFMSLHSDVFEKY-VNSWIAIAAPFQG 203
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
122-262 1.17e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 224001 [Multi-domain]  Cd Length: 336  Bit Score: 40.95  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241 122 VPGFGKTYsveyldnnklaGYMHTLVQNLVNNGYVRdETVRAAPYDWRLEPSQQEEYYRKLAGLVEEMHAAYG-KPVFLI 200
Cdd:COG1075  65 VHGLGGGY-----------GNFLPLDYRLAILGWLT-NGVYAFELSGGDGTYSLAVRGEQLFAYVDEVLAKTGaKKVNLI 132
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73957241 201 GHSLGCLHLLYFLLRQPQAWKdhfIDGFISLGAPWGGSikPMLVLASGDNQGIPIMSSIKLR 262
Cdd:COG1075 133 GHSMGGLDSRYYLGVLGGANR---VASVVTLGTPHHGT--ELADLVGLLIYVRSGEGLNNLR 189
 
Name Accession Description Interval E-value
LCAT pfam02450
Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved ...
81-406 8.70e-153

Lecithin:cholesterol acyltransferase; Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.


Pssm-ID: 396835  Cd Length: 383  Bit Score: 438.14  E-value: 8.70e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241    81 TIWLDLNMFLPLGVDCWIDNTRVVYNRSSGRVSNAPGVEIRVP-GFgktYSVEYLDNNKLAGY--MHTLVQNLVNNGYVR 157
Cdd:pfam02450   1 RIWLDLNMLLPLVVDCWIDNTHVVLNPSTGLQPDPPGVKIRAAqGF---ESVEYLDYSKLAGYwiWHKVVQNLVNIGYER 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   158 DETVRAAPYDWRLEPSQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLR-QPQAWKDHFIDGFISLGAPWG 236
Cdd:pfam02450  78 NKTVRAAPYDWRLSLEERDKYFHKLKQLIEEAHKLYGKKVVLIGHSMGNLLVLYFLLWvVAEAWKDQHIDAFISLGAPLL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   237 GSIKPMLVLASGDNQGIPIMSSIKLREEQRITTTSPWMFPSRE-------AWPEDHVFISTPSFNYTGRDFQRFFAD--- 306
Cdd:pfam02450 158 GSPKAVRALASGYNFGIPILSEITLRGLQRSFSSSPWMLPKGKyvlwsdvAWPSDEIFIQTPSINYTYGALVRFFDDeti 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   307 --------LHFEEGWYMWLQSRDLLAGLP------------------------APGVEVYCLYGVGLPTPRTYIFDHG-- 352
Cdd:pfam02450 238 nvdalgftLNTLDGWYMWKVSRDLDGGLPyleaelakndikywvnpeetplpvAPGVKVYCIYGVGLPTERGYYYTPGkt 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 73957241   353 -------FPYTDPVGVLYEDGDDTVATRSTELCARWQS-RQPQPVHLLPL----HGTEHLNMVFSN 406
Cdd:pfam02450 318 sspilsrIDYEDPVGIVSGDGDGTVPKRSLELCKNWQGlPAGQNVTVHELkhgsRSAEHVDILGSN 383
PLN02733 PLN02733
phosphatidylcholine-sterol O-acyltransferase
46-237 1.34e-06

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 215390  Cd Length: 440  Bit Score: 50.40  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   46 PVILVPGCLGNQLEAKLDKpdvvnwmcyRKTEEffTIWLDLnmflpLGVD------CWidntrVVYNRSSGR-VSNAPGV 118
Cdd:PLN02733  21 PVLLVPGIGGSILNAVDKD---------GGNEE--RVWVRI-----FAADhefrkkLW-----SRYDPKTGKtVSLDPKT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241  119 EIRVPG--FGkTYSVEYLDNNKLAG-----YMHTLVQNLVNNGYVRDETVRAAPYDWRlEPSQQEEYYRKLAGLVEEMH- 190
Cdd:PLN02733  80 EIVVPDdrYG-LYAIDILDPDVIIRldevyYFHDMIEQLIKWGYKEGKTLFGFGYDFR-QSNRLPETMDGLKKKLETVYk 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 73957241  191 AAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDHfIDGFISLGAPWGG 237
Cdd:PLN02733 158 ASGGKKVNIISHSMGGLLVKCFMSLHSDVFEKY-VNSWIAIAAPFQG 203
PLN02517 PLN02517
phosphatidylcholine-sterol O-acyltransferase
319-384 3.74e-04

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 178132  Cd Length: 642  Bit Score: 42.82  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241  319 SRDLLAGLP-APGVEVYCLYGVGLPTPRTYIFDHGFPYTDPV-------------------GVLYEDGDDTVATRSTE-L 377
Cdd:PLN02517 476 SNPLETKLPnAPEMEIYSLYGVGIPTERSYVYKLSPSDECSIpfqidtsadggdedsclkgGVYFVDGDETVPVLSAGfM 555

                 ....*...
gi 73957241  378 CAR-WQSR 384
Cdd:PLN02517 556 CAKgWRGK 563
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
142-274 3.79e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 432361 [Multi-domain]  Cd Length: 238  Bit Score: 41.82  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   142 YMHtLVQNLVNNGYVrdetVRAapYDWR---LEPSQQ------EEYYRKLAGLVEEMHAAY-GKPVFLIGHSLGCLHLLY 211
Cdd:pfam12146  20 YAH-LADALAAQGFA----VYA--YDHRghgRSDGKRghvpsfDDYVDDLDTFVDKIREEHpGLPLFLLGHSMGGLIAAL 92
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 73957241   212 FLLRQPQAW------------KDHFIDGFISLGAPWGGSIKPMLVLASGDNqgiPIMSSiKLREEQRITTTSPWM 274
Cdd:pfam12146  93 YALRYPDKVdglilsapalkiKPYLAPPILKLLAKLLGKLFPRLRVPNNLL---PDSLS-RDPEVVAAYAADPLV 163
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
122-262 1.17e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 224001 [Multi-domain]  Cd Length: 336  Bit Score: 40.95  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241 122 VPGFGKTYsveyldnnklaGYMHTLVQNLVNNGYVRdETVRAAPYDWRLEPSQQEEYYRKLAGLVEEMHAAYG-KPVFLI 200
Cdd:COG1075  65 VHGLGGGY-----------GNFLPLDYRLAILGWLT-NGVYAFELSGGDGTYSLAVRGEQLFAYVDEVLAKTGaKKVNLI 132
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73957241 201 GHSLGCLHLLYFLLRQPQAWKdhfIDGFISLGAPWGGSikPMLVLASGDNQGIPIMSSIKLR 262
Cdd:COG1075 133 GHSMGGLDSRYYLGVLGGANR---VASVVTLGTPHHGT--ELADLVGLLIYVRSGEGLNNLR 189
PLN02517 PLN02517
phosphatidylcholine-sterol O-acyltransferase
31-213 3.04e-03

phosphatidylcholine-sterol O-acyltransferase


Pssm-ID: 178132  Cd Length: 642  Bit Score: 39.74  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241   31 PPHTTPKAELSNHTRPVILVPGCLGNQLEAkldkpdvvnWMCYRKTEEFFTIWLDLNMF-----LPLgvdCWIDNTRVvy 105
Cdd:PLN02517  61 PPGVKLRKEGLTAKHPVVFVPGIVTGGLEL---------WEGHQCAEGLFRKRLWGGTFgevykRPL---CWVEHMSL-- 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73957241  106 NRSSGRvsNAPGVEIR-VPGFgktYSVEYLdnnkLAGYM--HTLVQNLVNNGYvRDETVRAAPYDWRLEPSQQEEYYRKL 182
Cdd:PLN02517 127 DNETGL--DPPGIRVRaVSGL---VAADYF----APGYFvwAVLIANLARIGY-EEKNMYMAAYDWRLSFQNTEVRDQTL 196
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 73957241  183 AGL---VEEMHAAYG-KPVFLIGHSLGCLHLLYFL 213
Cdd:PLN02517 197 SRLksnIELMVATNGgKKVVVVPHSMGVLYFLHFM 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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