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Conserved domains on  [gi|1907154523|ref|XP_036019663|]
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low-density lipoprotein receptor-related protein 8 isoform X30 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 146-186 8.11e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 65.26  E-value: 8.11e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154523 146 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 186
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 84-125 7.19e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 7.19e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907154523   84 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 125
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 170-212 3.25e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 3.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154523  170 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 212
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 233-273 6.54e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 6.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907154523 233 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 273
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 291-328 6.02e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154523 291 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 328
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 39-74 2.45e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907154523   39 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 74
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 146-186 8.11e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 65.26  E-value: 8.11e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154523 146 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 186
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 84-125 7.19e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 7.19e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907154523   84 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 125
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 170-212 3.25e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 3.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154523  170 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 212
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 104-143 1.23e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 53.70  E-value: 1.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154523 104 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 143
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 127-169 1.48e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 1.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154523  127 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 169
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 87-271 1.62e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  87 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 155
Cdd:cd05819    51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 156 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 227
Cdd:cd05819   129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907154523 228 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 271
Cdd:cd05819   201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 233-273 6.54e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 6.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907154523 233 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 273
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 190-232 3.85e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 3.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907154523 190 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 232
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 291-328 6.02e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154523 291 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 328
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
102-253 4.96e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 102 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 177
Cdd:COG3391    79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 178 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 253
Cdd:COG3391   152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 39-74 2.45e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907154523   39 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 74
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 146-186 8.11e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 65.26  E-value: 8.11e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154523 146 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 186
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 84-125 7.19e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 7.19e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907154523   84 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 125
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 170-212 3.25e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 3.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154523  170 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 212
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 104-143 1.23e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 53.70  E-value: 1.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154523 104 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 143
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 127-169 1.48e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 1.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154523  127 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 169
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 87-271 1.62e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  87 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 155
Cdd:cd05819    51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 156 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 227
Cdd:cd05819   129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907154523 228 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 271
Cdd:cd05819   201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 87-271 2.05e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.40  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  87 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMY-----------W 150
Cdd:cd05819     4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYvadtgnhriqkF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 151 SDWGfqAKIEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGnrkmLIF-------STDFLS 223
Cdd:cd05819    82 DPDG--NFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGE----FLTtfgsggsGPGQFN 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907154523 224 HPFGVAVF-EDKVFWTDLENEAI--FSAnrlNGLEIAILAEN------LNNPHDIVI 271
Cdd:cd05819   150 GPTGVAVDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 233-273 6.54e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 6.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907154523 233 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 273
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 190-232 3.85e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 3.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907154523 190 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 232
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 291-328 6.02e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154523 291 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 328
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
102-253 4.96e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 102 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 177
Cdd:COG3391    79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 178 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 253
Cdd:COG3391   152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 87-239 9.79e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.31  E-value: 9.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  87 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRcTLF------SRELSEPRAIAVDPlRGFMYWSDWG------ 154
Cdd:cd05819    98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFL-TTFgsggsgPGQFNGPTGVAVDS-DGNIYVADTGnhriqv 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 155 ------FQAKIEKAGLNGADRQTlvsdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNG------GNRkmlIFSTDFL 222
Cdd:cd05819   175 fdpdgnFLTTFGSTGTGPGQFNY--------PTGIAVD-SDGNIYVADSGNNRVQVFDPDGagfggnGNF---LGSDGQF 242

                         170
                  ....*....|....*...
gi 1907154523 223 SHPFGVAVFED-KVFWTD 239
Cdd:cd05819   243 NRPSGLAVDSDgNLYVAD 260
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 89-245 3.78e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.35  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  89 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPLrGFMYWSD-WGFqaKIEKA 162
Cdd:cd14956    11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 163 GLNGADRQTL-VSDNIE----WPNGITLDllSQRLYWVdsklhqlssIDFngGNRKMLIFSTD--FLS------------ 223
Cdd:cd14956    87 TLTGELQTIGgSSGSGPgqfnAPRGVAVD--ADGNLYV---------ADF--GNQRIQKFDPDgsFLRqwggtgiepgsf 153

                         170       180
                  ....*....|....*....|....
gi 1907154523 224 -HPFGVAVFEDKVFW-TDLENEAI 245
Cdd:cd14956   154 nYPRGVAVDPDGTLYvADTYNDRI 177
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 54-230 7.41e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.50  E-value: 7.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  54 ATNRIYWCDLSYRKIYSAHMDkasipDEQVVLIDEQLHSPEGLAVD-----WVhkhiywTDSGNKTISVATTDGRRR--C 126
Cdd:COG3386    17 PDGRLYWVDIPGGRIHRYDPD-----GGAVEVFAEPSGRPNGLAFDpdgrlLV------ADHGRGLVRFDPADGEVTvlA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 127 TLFSRELSEPRAIAVDPlRGFMYWSDwgFQAKIEKAGL---NGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 203
Cdd:COG3386    86 DEYGKPLNRPNDGVVDP-DGRLYFTD--MGEYLPTGALyrvDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIY 162

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907154523 204 SIDFNG----GNRKMLIFSTDFLSHPFGVAV 230
Cdd:COG3386   163 RFDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 87-274 1.40e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.43  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  87 DEQLHSPEGLAVDWvhKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDWGFQaKIEK 161
Cdd:cd14963     6 GDPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPgtgpgEFKYPYGIAVDS-DGNIYVADLYNG-RIQV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523 162 AGLNGADRQTLVSD----NIEWPNGITLDllSQRLYWVDSKLHQLSSIDFNGgnRKMLIFST--DF---LSHPFGVAVFE 232
Cdd:cd14963    82 FDPDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KLLLEFGKpgSEpgeLSYPNGIAVDE 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154523 233 DK-VFWTDLENEAI--FSAN-----RLNGLEIAilAENLNNP------------------HDIVIFHE 274
Cdd:cd14963   158 DGnIYVADSGNGRIqvFDKNgkfikELNGSPDG--KSGFVNPrgiavdpdgnlyvvdnlsHRVYVFDE 223
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 39-74 2.45e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907154523   39 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 74
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 10-200 2.49e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.96  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  10 AVAGKSPSLIF---TNRHEVRRIDLVKRDYSRLIP----MLKNVVALDVEVAtNRIYWCDLSYRKIYsaHMDkasiPDEQ 82
Cdd:cd14962    16 GVAADGRGRIYvadTGRGAVFVFDLPNGKVFVIGNagpnRFVSPIGVAIDAN-GNLYVSDAELGKVF--VFD----RDGK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  83 VV-LIDE--QLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDwG 154
Cdd:cd14962    89 FLrAIGAgaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgpgEFNLPTDLAVDR-DGNLYVTD-T 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907154523 155 FQAKIEKAGLNGADRQT-----LVSDNIEWPNGITLDlLSQRLYWVDSKLH 200
Cdd:cd14962   167 MNFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAFD 216
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
21-154 7.87e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 7.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154523  21 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYsahmdKASIPDEQVVLIDEQLHSPEGLAVDW 100
Cdd:COG3391    87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVS-----VIDTATGKVVATIPVGAGPHGIAVDP 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154523 101 VHKHIYWTDSGNKTISV-----ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWG 154
Cdd:COG3391   162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 56-100 1.65e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907154523  56 NRIYWCDLSYR-KIYSAHMDKASipdeQVVLIDEQLHSPEGLAVDW 100
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSD----RKTLFTDDLQHPNAIAVDP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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