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Conserved domains on  [gi|1907118421|ref|XP_036015892|]
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lebercilin-like protein isoform X3 [Mus musculus]

Protein Classification

Lebercilin domain-containing protein( domain architecture ID 12174059)

Lebercilin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
144-284 5.83e-51

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


:

Pssm-ID: 434815 [Multi-domain]  Cd Length: 193  Bit Score: 166.22  E-value: 5.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 144 MTHRILSARLHKIKELKNELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQLLRKSQ 223
Cdd:pfam15619   1 VTQRVLSARLHKIKELQNELAELQRKLEELRKENKLLKRLQRRQEKALGKYEDTESELPQLIARHNEEVRVLRERLRRSQ 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907118421 224 EKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTAKMEANDKKIQ 284
Cdd:pfam15619  81 EKERDLERKLKEKEAELLRLRDELKKLKKLSEDKNLAEREELQKKLAQLEAKLEEKEEKIQ 141
 
Name Accession Description Interval E-value
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
144-284 5.83e-51

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 434815 [Multi-domain]  Cd Length: 193  Bit Score: 166.22  E-value: 5.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 144 MTHRILSARLHKIKELKNELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQLLRKSQ 223
Cdd:pfam15619   1 VTQRVLSARLHKIKELQNELAELQRKLEELRKENKLLKRLQRRQEKALGKYEDTESELPQLIARHNEEVRVLRERLRRSQ 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907118421 224 EKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTAKMEANDKKIQ 284
Cdd:pfam15619  81 EKERDLERKLKEKEAELLRLRDELKKLKKLSEDKNLAEREELQKKLAQLEAKLEEKEEKIQ 141
MscK COG3264
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
138-274 1.96e-04

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225803 [Multi-domain]  Cd Length: 835  Bit Score: 42.75  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 138 AKRRDTMTHRI--LSARLHKIKELKNEL-ADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKN 214
Cdd:COG3264    14 QSRRELLTAESaqLEAALQLLQEAVNSKrQEEAEPAAEEAELQAELIQQELAINDQLSQALNQQTERLNALASDDRQLAN 93
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 215 LRQLLRKSQEKERAVSRKLRetdGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTA 274
Cdd:COG3264    94 LLLQLLQSSRTIREQIAVLR---GSLLLSRILLQQLGPLPEAGQPQEQFEVTQERDALQA 150
 
Name Accession Description Interval E-value
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
144-284 5.83e-51

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 434815 [Multi-domain]  Cd Length: 193  Bit Score: 166.22  E-value: 5.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 144 MTHRILSARLHKIKELKNELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQLLRKSQ 223
Cdd:pfam15619   1 VTQRVLSARLHKIKELQNELAELQRKLEELRKENKLLKRLQRRQEKALGKYEDTESELPQLIARHNEEVRVLRERLRRSQ 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907118421 224 EKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTAKMEANDKKIQ 284
Cdd:pfam15619  81 EKERDLERKLKEKEAELLRLRDELKKLKKLSEDKNLAEREELQKKLAQLEAKLEEKEEKIQ 141
MscK COG3264
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
138-274 1.96e-04

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225803 [Multi-domain]  Cd Length: 835  Bit Score: 42.75  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 138 AKRRDTMTHRI--LSARLHKIKELKNEL-ADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKN 214
Cdd:COG3264    14 QSRRELLTAESaqLEAALQLLQEAVNSKrQEEAEPAAEEAELQAELIQQELAINDQLSQALNQQTERLNALASDDRQLAN 93
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118421 215 LRQLLRKSQEKERAVSRKLRetdGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTA 274
Cdd:COG3264    94 LLLQLLQSSRTIREQIAVLR---GSLLLSRILLQQLGPLPEAGQPQEQFEVTQERDALQA 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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