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Conserved domains on  [gi|1907074891|ref|XP_036011657|]
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transducin-like enhancer protein 2 isoform X31 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
70-320 8.88e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 453027 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 8.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  70 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQSLIVGG 143
Cdd:cd00200    42 ELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGRILSSSS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 144 EASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGT 223
Cdd:cd00200   113 RDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 224 RLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFA 301
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWS 270
                         250
                  ....*....|....*....
gi 1907074891 302 SCGRWFVSTGKDNLLNAWR 320
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
70-320 8.88e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 8.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  70 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQSLIVGG 143
Cdd:cd00200    42 ELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGRILSSSS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 144 EASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGT 223
Cdd:cd00200   113 RDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 224 RLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFA 301
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWS 270
                         250
                  ....*....|....*....
gi 1907074891 302 SCGRWFVSTGKDNLLNAWR 320
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
76-334 1.22e-24

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 105.94  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  76 AHGEVVCAVTISSSTQHVYTGG--KGCVKVWDVGQPgskTPVAQLDclNRDNYIRSCKLLPDGQSLIVG-GEASTLSIWD 152
Cdd:COG2319   153 GHSESVTSLAFSPDGKLLASGSslDGTIKLWDLRTG---KPLSTLA--GHTDPVSSLAFSPDGGLLIASgSSDGTIRLWD 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 153 LaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQN-QAMVRQFQGHTDGASCIDISDYGTRLWTGGLD 231
Cdd:COG2319   228 L--STGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSsSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSD 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 232 NTVRCWDLREGRQLQQHDF---SSQIFSLGHCPNQDWLAVG-MESSHVEVLHVRKPEKYQLRLHESCVLSLKFASCGRWF 307
Cdd:COG2319   306 GTVRLWDLETGKLLSSLTLkghEGPVSSLSFSPDGSLLVSGgSDDGTIRLWDLRTGKPLKTLEGHSNVLSVSFSPDGRVV 385
                         250       260
                  ....*....|....*....|....*..
gi 1907074891 308 VSTGKDNLLNAWRTPYGASIFQVTCPG 334
Cdd:COG2319   386 SSGSTDGTVRLWDLSTGSLLRNLDGHT 412
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
203-238 3.08e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907074891  203 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 238
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-238 3.20e-05

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907074891 203 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 238
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
70-320 8.88e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 8.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  70 RQLHTL-AHGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGQPgsktpvaqlDCLNR----DNYIRSCKLLPDGQSLIVGG 143
Cdd:cd00200    42 ELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGRILSSSS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 144 EASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGT 223
Cdd:cd00200   113 RDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 224 RLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFA 301
Cdd:cd00200   191 KLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWS 270
                         250
                  ....*....|....*....
gi 1907074891 302 SCGRWFVSTGKDNLLNAWR 320
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
77-321 1.13e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  77 HGEVVCAVTISSSTQHVYTGGK-GCVKVWDV-GQPGSKTPVAQLDClnrdnyIRSCKLLPDGQSLIVGGEASTLSIWDLa 154
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLeTGELLRTLKGHTGP------VRDVAASADGTYLASGSSDKTIRLWDL- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 155 aPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV 234
Cdd:cd00200    81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 235 RCWDLREGR---QLQQHDfsSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFASCGRWFVST 310
Cdd:cd00200   160 KLWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASG 237
                         250
                  ....*....|.
gi 1907074891 311 GKDNLLNAWRT 321
Cdd:cd00200   238 SEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
76-334 1.22e-24

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 105.94  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  76 AHGEVVCAVTISSSTQHVYTGG--KGCVKVWDVGQPgskTPVAQLDclNRDNYIRSCKLLPDGQSLIVG-GEASTLSIWD 152
Cdd:COG2319   153 GHSESVTSLAFSPDGKLLASGSslDGTIKLWDLRTG---KPLSTLA--GHTDPVSSLAFSPDGGLLIASgSSDGTIRLWD 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 153 LaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQN-QAMVRQFQGHTDGASCIDISDYGTRLWTGGLD 231
Cdd:COG2319   228 L--STGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSsSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSD 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 232 NTVRCWDLREGRQLQQHDF---SSQIFSLGHCPNQDWLAVG-MESSHVEVLHVRKPEKYQLRLHESCVLSLKFASCGRWF 307
Cdd:COG2319   306 GTVRLWDLETGKLLSSLTLkghEGPVSSLSFSPDGSLLVSGgSDDGTIRLWDLRTGKPLKTLEGHSNVLSVSFSPDGRVV 385
                         250       260
                  ....*....|....*....|....*..
gi 1907074891 308 VSTGKDNLLNAWRTPYGASIFQVTCPG 334
Cdd:COG2319   386 SSGSTDGTVRLWDLSTGSLLRNLDGHT 412
WD40 COG2319
WD40 repeat [General function prediction only];
70-319 7.32e-24

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 103.63  E-value: 7.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  70 RQLHTLA-HGEVVCAVTISSSTQHVYTGG--KGCVKVWDVgqpgSKTPVAQLDCLNRDNYIRSCkLLPDGQSLIVGGEAS 146
Cdd:COG2319   189 KPLSTLAgHTDPVSSLAFSPDGGLLIASGssDGTIRLWDL----STGKLLRSTLSGHSDSVVSS-FSPDGSLLASGSSDG 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 147 TLSIWDLAAPTPRIKAELTSSAPACyALAVSPDAKVCFSCCSDGNIVVWDLQNQ--AMVRQFQGHTDGASCIDISDYGTR 224
Cdd:COG2319   264 TIRLWDLRSSSSLLRTLSGHSSSVL-SVAFSPDGKLLASGSSDGTVRLWDLETGklLSSLTLKGHEGPVSSLSFSPDGSL 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 225 LWTGG-LDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPE-KYQLRLHESCVLSLKFAS 302
Cdd:COG2319   343 LVSGGsDDGTIRLWDLRTGKPLKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSlLRNLDGHTSRVTSLDFSP 422
                         250
                  ....*....|....*..
gi 1907074891 303 CGRWFVSTGKDNLLNAW 319
Cdd:COG2319   423 DGKSLASGSSDNTIRLW 439
WD40 COG2319
WD40 repeat [General function prediction only];
124-334 8.76e-17

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 82.06  E-value: 8.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 124 DNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKA----------------------------------------- 162
Cdd:COG2319    65 EDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKSleglhdssvsklalsspdgnsillasssldgtvklwdlstp 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 163 -----ELTSSAPACYALAVSPDAKVCFSCCS-DGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTR-LWTGGLDNTVR 235
Cdd:COG2319   145 gklirTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLlIASGSSDGTIR 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 236 CWDLREGRQLQQH-----DFSSQIFSlghcPNQDWLAVGMESSHVEVLHVR--KPEKYQLRLHESCVLSLKFASCGRWFV 308
Cdd:COG2319   225 LWDLSTGKLLRSTlsghsDSVVSSFS----PDGSLLASGSSDGTIRLWDLRssSSLLRTLSGHSSSVLSVAFSPDGKLLA 300
                         250       260
                  ....*....|....*....|....*.
gi 1907074891 309 STGKDNLLNAWRTPYGASIFQVTCPG 334
Cdd:COG2319   301 SGSSDGTVRLWDLETGKLLSSLTLKG 326
WD40 COG2319
WD40 repeat [General function prediction only];
77-254 7.05e-16

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 79.36  E-value: 7.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891  77 HGEVVCAVTISSSTQHVYTGGK-GCVKVWDVGqpgSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEA-STLSIWDLA 154
Cdd:COG2319   283 HSSSVLSVAFSPDGKLLASGSSdGTVRLWDLE---TGKLLSSLTLKGHEGPVSSLSFSPDGSLLVSGGSDdGTIRLWDLR 359
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 155 AptpRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV 234
Cdd:COG2319   360 T---GKPLKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTI 436
                         170       180
                  ....*....|....*....|
gi 1907074891 235 RCWDLREGRQLQQHDFSSQI 254
Cdd:COG2319   437 RLWDLKTSLKSVSFSPDGKV 456
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
202-324 2.63e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 202 MVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREG---RQLQQHdfSSQIFSLGHCPNQDWLAVGMESSHVEVL 278
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1907074891 279 HVRKPEK-YQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYG 324
Cdd:cd00200    79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 COG2319
WD40 repeat [General function prediction only];
174-327 1.93e-09

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 59.33  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 174 LAVSPDAKVCFSCCSDGNIVVWDLQNQAmvrqFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL-----QQH 248
Cdd:COG2319    33 LGSSESGILLLALLSDSLVSLPDLSSLL----LRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLiksleGLH 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074891 249 DFSSQIFSLGHcPNQDWLAVGMESSH--VEVLHVRKPEK--YQLRLHESCVLSLKFASCGRWFVSTG-KDNLLNAWRTPY 323
Cdd:COG2319   109 DSSVSKLALSS-PDGNSILLASSSLDgtVKLWDLSTPGKliRTLEGHSESVTSLAFSPDGKLLASGSsLDGTIKLWDLRT 187

                  ....
gi 1907074891 324 GASI 327
Cdd:COG2319   188 GKPL 191
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
203-238 3.08e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907074891  203 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 238
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-238 3.20e-05

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907074891 203 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 238
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
157-196 4.63e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907074891  157 TPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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