|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
1-595 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 936.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:TIGR01787 51 IVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMY 160
Cdd:TIGR01787 131 GVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 161 TPHSWLLHVVYGLLNL-YERFHSTSLRKWAVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRI 239
Cdd:TIGR01787 203 TPHSWLLRALYGLLNLfYHPFLRKALRKRALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 240 KDYLWLGLDGMKMQGTnGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSF 318
Cdd:TIGR01787 277 DDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAF 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 319 STLDCGW-IVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGD 397
Cdd:TIGR01787 356 SFLNCGYpDVDDTAVVALKAVLLLQE-----DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGD 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 398 IMIDYTYVECTSAVMQALKHFhehfpDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTY 477
Cdd:TIGR01787 431 IMIDPPYVDVTARVIQALGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTY 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 478 QDgaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLP 557
Cdd:TIGR01787 506 RN---CPEVQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRP 582
|
570 580 590
....*....|....*....|....*....|....*....
gi 1907073706 558 NGDWPQENISGVFN-KSCAISYTSYRNIFPIWALGRFSN 595
Cdd:TIGR01787 583 DGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
1-593 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 883.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:cd02892 51 IARYLRNHQNPDGGWGLHHEGPSTMFGTVLNYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVspDEMY 160
Cdd:cd02892 131 GVPPLPPELWLLPSWLPFHPYKFWCWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 161 TPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIK 240
Cdd:cd02892 209 PPWQRLFDALDRLLHWYEPLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERID 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 241 DYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFST 320
Cdd:cd02892 289 DFLWLGPEGMKMCQTNGSQVWDTALAVQALLEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFST 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 321 LDCGWIVADCTAEGLKAVLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMI 400
Cdd:cd02892 367 ANQGYPDSDDTAEALKALLRLQE-LPPFGEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMI 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 401 DYTYVECTSAVMQALKHFHEHFPDYRaAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDg 480
Cdd:cd02892 446 DPPYVECTGSVLEALGLFGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN- 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 481 aaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGD 560
Cdd:cd02892 524 --SPYIRKACDFLLSKQNPDGGWGESYLSYEDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGD 601
|
570 580 590
....*....|....*....|....*....|...
gi 1907073706 561 WPQENISGVFNKSCAISYTSYRNIFPIWALGRF 593
Cdd:cd02892 602 WPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
1-593 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 571.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPD---DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVY 77
Cdd:PLN03012 152 ILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVF 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 78 SWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPD 157
Cdd:PLN03012 232 DWSGSNPMPPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKE 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 158 EMYTPHSWLLHVVYGLLNLY-ERF-----HSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPA 231
Cdd:PLN03012 312 DAYCPHPLIQDLIWDCLYIFaEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDH 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 232 FQEHVSRIKDYLWLGLDGMKMQgTNGSQIWDTSFAIQALLEAGAHHrpEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRH 310
Cdd:PLN03012 391 FKKHLLRISDYLWIAEDGMKMQ-SFGSQLWDSGFALQALLASNLSN--EIPDVLRRGHDFIKNSQVGENpSGDFKNMYRH 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 311 MRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEhiPR---ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLE 387
Cdd:PLN03012 468 ISKGAWTFSDRDHGWQASDCTAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLE 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 388 LLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGL 467
Cdd:PLN03012 546 LLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFAL 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 468 EAFACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSA--RSQVHSTCWALMGLM----AVRHPdi 541
Cdd:PLN03012 626 AGLAAAGKTFND---CEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP-- 700
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 1907073706 542 TAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 593
Cdd:PLN03012 701 IPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEY 752
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
1-597 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 564.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:COG1657 74 IARYLRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWR 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVQDYASID--WPAQRnnvspde 158
Cdd:COG1657 154 GVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPR------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 159 MYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQ-----MLyEHIAADDCFtkcISIGP-ISKTINMLvRWSVDGPSSPAF 232
Cdd:COG1657 225 DRSPWSRFFLALDRLLRAYERLPPKPLRRRALRkaedwIL-ERLEGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVV 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 233 QEHVSRIKDYLWLGLDGMKMQGtNGSQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMR 312
Cdd:COG1657 300 RRALEALEKLLVETEDGARCQP-CVSPVWDTALAVQALQEAG---LPEDHPALERAADWLLSKQILVK-GDWAVKRPDVE 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 313 KGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPS 392
Cdd:COG1657 375 PGGWAFQFANDHYPDVDDTAVVLMALLRLRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFA 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 393 EvFGdIMIDYTYVECTSAVMQALKHfhehfpdYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFAC 472
Cdd:COG1657 451 D-HG-ALLDPPTADVTARCLEMLGQ-------LGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNA 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 473 MGHTYQDGAacaeVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLL 552
Cdd:COG1657 522 AGVDPDDPA----IRRAVAWLLSIQNADGGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLL 597
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 1907073706 553 GKQLPNGDWPQENISGV-FNKSCAISYTSYRNIFPIWALGRFSNLY 597
Cdd:COG1657 598 STQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLR 643
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
258-595 |
4.43e-51 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 178.68 E-value: 4.43e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 258 SQIWDTSFAIQALLEAGAhhrPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkA 337
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVK-GDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 338 VLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 415
Cdd:pfam13243 74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 416 KHFHehFPDYRAAEVRetlnqGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLS 495
Cdd:pfam13243 150 GQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY----IRKAVDWLKS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 496 QQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMA---VRHPditAQERGIRCLLGKQLPNGDWPQENISGV-FN 571
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAageVDSP---AVRRGIQYLLETQKPDGTWDEPYFTGTgFP 295
|
330 340
....*....|....*....|....
gi 1907073706 572 KSCAISYTSYRNIFPIWALGRFSN 595
Cdd:pfam13243 296 RVFYLKYHGYRNYFPLWALARYRN 319
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
1-595 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 936.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:TIGR01787 51 IVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMY 160
Cdd:TIGR01787 131 GVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 161 TPHSWLLHVVYGLLNL-YERFHSTSLRKWAVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRI 239
Cdd:TIGR01787 203 TPHSWLLRALYGLLNLfYHPFLRKALRKRALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 240 KDYLWLGLDGMKMQGTnGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSF 318
Cdd:TIGR01787 277 DDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAF 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 319 STLDCGW-IVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGD 397
Cdd:TIGR01787 356 SFLNCGYpDVDDTAVVALKAVLLLQE-----DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGD 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 398 IMIDYTYVECTSAVMQALKHFhehfpDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTY 477
Cdd:TIGR01787 431 IMIDPPYVDVTARVIQALGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTY 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 478 QDgaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLP 557
Cdd:TIGR01787 506 RN---CPEVQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRP 582
|
570 580 590
....*....|....*....|....*....|....*....
gi 1907073706 558 NGDWPQENISGVFN-KSCAISYTSYRNIFPIWALGRFSN 595
Cdd:TIGR01787 583 DGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
1-593 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 883.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:cd02892 51 IARYLRNHQNPDGGWGLHHEGPSTMFGTVLNYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVspDEMY 160
Cdd:cd02892 131 GVPPLPPELWLLPSWLPFHPYKFWCWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 161 TPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIK 240
Cdd:cd02892 209 PPWQRLFDALDRLLHWYEPLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERID 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 241 DYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFST 320
Cdd:cd02892 289 DFLWLGPEGMKMCQTNGSQVWDTALAVQALLEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFST 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 321 LDCGWIVADCTAEGLKAVLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMI 400
Cdd:cd02892 367 ANQGYPDSDDTAEALKALLRLQE-LPPFGEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMI 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 401 DYTYVECTSAVMQALKHFHEHFPDYRaAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDg 480
Cdd:cd02892 446 DPPYVECTGSVLEALGLFGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN- 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 481 aaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGD 560
Cdd:cd02892 524 --SPYIRKACDFLLSKQNPDGGWGESYLSYEDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGD 601
|
570 580 590
....*....|....*....|....*....|...
gi 1907073706 561 WPQENISGVFNKSCAISYTSYRNIFPIWALGRF 593
Cdd:cd02892 602 WPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
1-593 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 603.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLH-KKGGAVAIPSWGKFWLAVLNVYSW 79
Cdd:TIGR03463 44 IIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLLGLGKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYER 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 80 EGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASE-DPLVQSLRQELYVQDYASIDWPAQRNNVSPDE 158
Cdd:TIGR03463 124 EGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWLSGRGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTD 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 159 MYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDgPSSPAFQEHVSR 238
Cdd:TIGR03463 204 LFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHD-PDGPDLAAHLEG 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 239 IKDYLWLGLD-GMKMQGTNGSQIWDTSFAIQALLEAGaHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFS 317
Cdd:TIGR03463 283 LEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALG-ELDEEAKHALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWC 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 318 FSTLDCGWIVADCTAEGLKAVLLLQNQ-CPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFG 396
Cdd:TIGR03463 362 FSDGDHCWPISDCAAEALKALFALEELgDNRISEALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFG 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 397 DIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHT 476
Cdd:TIGR03463 442 QCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAE 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 477 YQDGAacaeVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQL 556
Cdd:TIGR03463 522 PADMA----LQAAAAFLLEKQRADGAWGEHVESCLEARWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQG 597
|
570 580 590
....*....|....*....|....*....|....*..
gi 1907073706 557 PNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 593
Cdd:TIGR03463 598 EDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
1-593 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 571.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPD---DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVY 77
Cdd:PLN03012 152 ILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVF 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 78 SWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPD 157
Cdd:PLN03012 232 DWSGSNPMPPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKE 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 158 EMYTPHSWLLHVVYGLLNLY-ERF-----HSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPA 231
Cdd:PLN03012 312 DAYCPHPLIQDLIWDCLYIFaEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDH 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 232 FQEHVSRIKDYLWLGLDGMKMQgTNGSQIWDTSFAIQALLEAGAHHrpEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRH 310
Cdd:PLN03012 391 FKKHLLRISDYLWIAEDGMKMQ-SFGSQLWDSGFALQALLASNLSN--EIPDVLRRGHDFIKNSQVGENpSGDFKNMYRH 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 311 MRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEhiPR---ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLE 387
Cdd:PLN03012 468 ISKGAWTFSDRDHGWQASDCTAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLE 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 388 LLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGL 467
Cdd:PLN03012 546 LLNPTEMFADIVIEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFAL 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 468 EAFACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSA--RSQVHSTCWALMGLM----AVRHPdi 541
Cdd:PLN03012 626 AGLAAAGKTFND---CEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP-- 700
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 1907073706 542 TAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 593
Cdd:PLN03012 701 IPLHRAAKLIINSQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEY 752
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
1-597 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 564.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:COG1657 74 IARYLRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWR 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVQDYASID--WPAQRnnvspde 158
Cdd:COG1657 154 GVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPR------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 159 MYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQ-----MLyEHIAADDCFtkcISIGP-ISKTINMLvRWSVDGPSSPAF 232
Cdd:COG1657 225 DRSPWSRFFLALDRLLRAYERLPPKPLRRRALRkaedwIL-ERLEGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVV 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 233 QEHVSRIKDYLWLGLDGMKMQGtNGSQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMR 312
Cdd:COG1657 300 RRALEALEKLLVETEDGARCQP-CVSPVWDTALAVQALQEAG---LPEDHPALERAADWLLSKQILVK-GDWAVKRPDVE 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 313 KGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPS 392
Cdd:COG1657 375 PGGWAFQFANDHYPDVDDTAVVLMALLRLRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFA 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 393 EvFGdIMIDYTYVECTSAVMQALKHfhehfpdYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFAC 472
Cdd:COG1657 451 D-HG-ALLDPPTADVTARCLEMLGQ-------LGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNA 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 473 MGHTYQDGAacaeVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLL 552
Cdd:COG1657 522 AGVDPDDPA----IRRAVAWLLSIQNADGGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLL 597
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 1907073706 553 GKQLPNGDWPQENISGV-FNKSCAISYTSYRNIFPIWALGRFSNLY 597
Cdd:COG1657 598 STQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLR 643
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
1-593 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 537.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPD---DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVY 77
Cdd:PLN02993 152 MLRHIYCHQNEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIY 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 78 SWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPD 157
Cdd:PLN02993 232 DWSGTNPMPPEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKE 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 158 EMYTPHSWLLHVVYGLLNLYERFHSTS------LRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPA 231
Cdd:PLN02993 312 DMYYPHPLVQDLIWDTLHNFVEPFLTRwplnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDH 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 232 FQEHVSRIKDYLWLGLDGMKMQgTNGSQIWDTSFAIQALLeaGAHHRPEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRH 310
Cdd:PLN02993 391 FKKHLARIPDYMWVAEDGMKMQ-SFGSQLWDTGFAIQALL--ASDLSDETDDVLRRGHNYIKKSQVRENpSGDFKSMYRH 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 311 MRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSIT-EHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELL 389
Cdd:PLN02993 468 ISKGAWTLSDRDHGWQVSDCTAEALKCCMLLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELL 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 390 NPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEA 469
Cdd:PLN02993 548 NPTDFFANTMVEREYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGG 627
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 470 FACMGHTYQDgaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYV--QSARSQVHSTCWALMGLMAVRHP--DITAQE 545
Cdd:PLN02993 628 LAAAGKTYND---CLAMRKGVHFLLTIQRDDGGWGESYLSCPEQRYIplEGNRSNLVQTAWAMMGLIHAGQAerDLIPLH 704
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1907073706 546 RGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 593
Cdd:PLN02993 705 RAAKLIITSQLENGDFPQQEILGAFMNTCMLHYATYRNTFPLWALAEY 752
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
258-593 |
4.16e-170 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 487.50 E-value: 4.16e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 258 SQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKA 337
Cdd:cd02889 23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 338 VLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELlnPSEVFGDIMIDYTYVECTSAVMQALKH 417
Cdd:cd02889 101 LLRLQK-KPPDGKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 418 FHEHFPDYRAaEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTyqdgAACAEVAQACNFLLSQQ 497
Cdd:cd02889 178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED----ENSPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 498 MADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAIS 577
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
|
330
....*....|....*.
gi 1907073706 578 YTSYRNIFPIWALGRF 593
Cdd:cd02889 333 YHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
3-596 |
2.21e-57 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 203.97 E-value: 2.21e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 3 RYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGL 82
Cdd:TIGR01507 69 NYLLHEQREDGTWALYPGGPGDLSTTVEAYVALKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 83 NTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSAsedPLVQSLR-QELYVQDyasidwpaqrnnVSPDEMYT 161
Cdd:TIGR01507 149 PMVPPEIMLLPKRFPFNIYEFSSWARATVVPLSIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRG 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 162 PHS-WLLHVVYGL---LNLYERFHSTSLRKWAVQM----LYEHIAADDCFTkcisiGPISKTINMLVRWSVDG-PSSPAF 232
Cdd:TIGR01507 214 AKGgTGWGIFDALdraLHGYEKLSVHPFRRAAEIRaldwLLERQAGDGSWG-----GIQPAMFNALIALKILGmTQHDAF 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 233 -QEHVSRIKDYLWLGLDGMKMQGTNgSQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVpeNCP-DYQKYYRH 310
Cdd:TIGR01507 289 iKLGWEGIDLYGVELDDSWMFQACV-SPVWDTALAVLALREAG---LPADHDALVKAGEWLLDKQI--TVPgDWAVKRPN 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 311 MRKGGFSFSTLDCGWIVADCTAeglkAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLN 390
Cdd:TIGR01507 363 LEPGGWAFQFDNVYYPDVDDTA----VVVWALNGLRLPDERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 391 psevFGDI--MIDYTYVECTSAVMQALKHFHEHFPdyraaevRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLE 468
Cdd:TIGR01507 439 ----FCDFgaVTDPPTADVTARVLECLGSFGYDDA-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLS 507
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 469 AFACMGHTYQDgaacAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGI 548
Cdd:TIGR01507 508 ALKAVGIDTRE----PYIQKALAWLESHQNPDGGWGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGV 583
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 1907073706 549 RCLLGKQLPNGDWPQENISGV-FNKSCAISYTSYRNIFPIWALGRFSNL 596
Cdd:TIGR01507 584 QYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMYRHVFPLLALARYKQA 632
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
236-593 |
5.88e-53 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 183.14 E-value: 5.88e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 236 VSRIKDYL--WLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAH--HRPEFLPCLQKAHEFLRLSQVPencpdyqkyyrhm 311
Cdd:cd00688 1 IEKHLKYLlrYPYGDGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLS------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 312 rKGGFSFSTLDcGWIVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKkrggyllellnp 391
Cdd:cd00688 68 -DGGFSGWGGN-DYPSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDGP------------ 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 392 seVFGDIMIDYTYVECTSAVMQALKHFHEHFPDyraaevrETLNQGLDFCRRKQRADGSWeGSWGVCFTYGTWFGLEAFA 471
Cdd:cd00688 129 --GNHRIGGDESDVRLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALA 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 472 CMGHTYQDgaacaEVAQACNFLLSQQMADGGWGEdfesceqRRYVQSARSQVHSTCWALMGLMA-VRHPDITAQERGIRC 550
Cdd:cd00688 199 LLGDLDSP-----DAKKALRWLLSRQRPDGGWGE-------GRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKW 266
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1907073706 551 LLGKQLPNGDWPQENIsgvfnkscaISYTSYRNIFPIWALGRF 593
Cdd:cd00688 267 LLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
258-595 |
4.43e-51 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 178.68 E-value: 4.43e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 258 SQIWDTSFAIQALLEAGAhhrPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkA 337
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVK-GDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 338 VLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 415
Cdd:pfam13243 74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 416 KHFHehFPDYRAAEVRetlnqGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLS 495
Cdd:pfam13243 150 GQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY----IRKAVDWLKS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 496 QQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMA---VRHPditAQERGIRCLLGKQLPNGDWPQENISGV-FN 571
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAageVDSP---AVRRGIQYLLETQKPDGTWDEPYFTGTgFP 295
|
330 340
....*....|....*....|....
gi 1907073706 572 KSCAISYTSYRNIFPIWALGRFSN 595
Cdd:pfam13243 296 RVFYLKYHGYRNYFPLWALARYRN 319
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
1-203 |
1.72e-41 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 151.87 E-value: 1.72e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWE 80
Cdd:pfam13249 50 IARYLRSQQREDGGWPLFHGGPGDLSTTVEAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 81 GLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvQSLRQELYVQDYASIDWPAQRnnvspdemY 160
Cdd:pfam13249 130 GVPSMPPEIMLLPRWFPFNIYKFSSWARTTIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRYYPRP--------H 199
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1907073706 161 TPHSW--LLHVVYGLLNLYERFHSTSLRKWAVQ-----MLyEHIAADDCF 203
Cdd:pfam13249 200 RLFSWtnLFLGLDRVLKLYERLPPKPLRRRALRkaeewIL-ERQEGDGGL 248
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
5-593 |
5.37e-24 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 106.64 E-value: 5.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 5 LRSVQLPDGGWgLHIEDKSTVFG----TALNYVALRILGIGPD-DPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSW 79
Cdd:TIGR04277 77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 80 EGL----------NTLFPEMW---LFPEWVPAHPSTLwchcrqvylpmSYCYATRLSAseDPLVQSLRqELYvqdyasID 146
Cdd:TIGR04277 156 EDLfkiplfifkkKGIFKPLYikdITAQWVYPHLTAL-----------AYLQNQRIIF--NVAVADIR-ELW------IN 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 147 WPAQRNNVSPDEMYT--PHSWLLHVVYGLLNLYERFhsTSLRKWAVQMLYEHIAADDcFTkcisigpiSKTINMlvrwsv 224
Cdd:TIGR04277 216 KAKKGIKHQKKERPSffIDNDLLILMDEIFKLKQPL--GSFGAYTISTLLSLLAFKD-FQ--------GKHPHK------ 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 225 dgpsspafqeHVSRIKDYLWLGLDGMKM------QGTNGS----QIWDTSFAIQALLEAGaHHRPEFLPCLQKaheFLRL 294
Cdd:TIGR04277 279 ----------HKNEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESG-EDKEKIFPIVEN---MLKE 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 295 SQVPENCPDYqkyyrhmrkgGFSFStldcgwIVADCTAEGLKAVLLlqnqcpSITEHIPRERLCDAVDVLLSLRNADGGF 374
Cdd:TIGR04277 345 GLQPKGGIEY----------GYDFE------YAPDADDTGLLLQVL------SYYGEAFADAIDEGAEFLFSMQNDDGGF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 375 ATYEK-KRGGYLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALKHFhehfpDYRAAevRETLNQGLDFCRRKQ 445
Cdd:TIGR04277 403 PAFDKgKMEDNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEF-----GDQAN--HDQIQKMIKYFMDTQ 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 446 RADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLSQQMADGGWGEDFESC-EQRRYVQSARSQVH 524
Cdd:TIGR04277 471 EKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYnDPEKWNGIGKSTVT 546
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907073706 525 STCWALMGLMAVR-HPDIT--AQERGIRCLLGK-QLPNGDWPQENISGVFNKSCA-ISYTSYRNIFPIWALGRF 593
Cdd:TIGR04277 547 QTSWGLLALLAVEdHNDQIkeAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
1-39 |
3.45e-08 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 49.82 E-value: 3.45e-08
10 20 30
....*....|....*....|....*....|....*....
gi 1907073706 1 MVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILG 39
Cdd:pfam00432 6 LVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
352-559 |
7.63e-08 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 53.94 E-value: 7.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 352 IPRERLCDAVDVLLSLRNADGGFATYEkkrggyllellNPSEVFgdimidYTYVECTSAVMQALKHFHEHFPdyraaevr 431
Cdd:COG5029 16 STADFTDSHLDYLRASQNPDGGFAGRS-----------GPSDLY------STYYAVRTLALLGESPKWRDRV-------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 432 etlnqgLDFCRRKQRADGSW----EGSWGvcFTYGTWFGLEAFACMGhtyqdgAACAEVAQACNFLLSQQMADGGWGEDF 507
Cdd:COG5029 71 ------ADLLSSLRVEDGGFakapEGGAG--STYHTYLATLLAELLG------RPPPDPDRLVRFLISQQNDDGGFEISP 136
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1907073706 508 esceqrryvqSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNG 559
Cdd:COG5029 137 ----------GRRSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
435-474 |
2.60e-07 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 47.12 E-value: 2.60e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1907073706 435 NQGLDFCRRKQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 474
Cdd:pfam00432 4 EKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
486-532 |
3.59e-05 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 41.34 E-value: 3.59e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907073706 486 VAQACNFLLSQQMADGGWGEDFESCeqrryVQSARSQVHSTCWALMG 532
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
2-51 |
7.35e-05 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 44.70 E-value: 7.35e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907073706 2 VRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGpDDPDLVRAR 51
Cdd:COG5029 119 VRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVI 167
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
291-450 |
3.25e-04 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 42.79 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 291 FLRLSQVPENCPDYQKYYRHMRK--GGFSFS---TLDCGWivadctaeglkAVLLLQnqcpSITEHIPRERlcDAVDVLL 365
Cdd:COG1689 127 LEALGASEPEREKIREFLLSLRRpdGGFGGKkpnLEDTYW-----------ALAALR----RLGRDLPPAD--RVIAFIL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 366 SLRNADGGFAtyekkrggyllelLNPSevfgdimiDYTYVECTSAVMQALKHFHEHFPDYRAAevretlnqgLDFCRRKQ 445
Cdd:COG1689 190 ACQNEDGGFS-------------KTPG--------SYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQ 239
|
....*
gi 1907073706 446 RADGS 450
Cdd:COG1689 240 NSDGG 244
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
428-503 |
2.26e-03 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 41.03 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073706 428 AEVRETLNQGLDFCRRKQRADGSWegswgvcftygtWFGLEAFACMG------HTYQDGAACAEVAQACNFLLSQQMADG 501
Cdd:TIGR01507 12 ARTVEAIDRAVDYLLSCQKDEGYW------------WGELESNVTIEaeyvllCHILDRVDRDRMEKIRNYLLHEQREDG 79
|
..
gi 1907073706 502 GW 503
Cdd:TIGR01507 80 TW 81
|
|
| |
