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Conserved domains on  [gi|1907073704|ref|XP_036011543|]
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prolow-density lipoprotein receptor-related protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4031-4072 7.16e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 65.26  E-value: 7.16e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 4031 GTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDY 4072
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3112-3154 2.85e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 2.85e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3112 QVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYR 3154
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1977-2017 3.89e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.39  E-value: 3.89e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1977 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFR 2017
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3200-3241 1.29e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 1.29e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  3200 IIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNR 3241
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3973-4010 3.57e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 3.57e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907073704  3973 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENR 4010
Cdd:smart00135    6 SGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4055-4096 4.14e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.31  E-value: 4.14e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  4055 ETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD 4096
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3593-3627 6.50e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 6.50e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3593 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3627
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3554-3588 1.87e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 1.87e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3554 CEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3588
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1354-1394 2.98e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 2.98e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1354 EVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGT 1394
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 641-690 3.77e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 3.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1907073704   641 KTLIEGKMTHPRAIVVDPLNGWMYWTDWeedpkdsRRGRLERAWMDGSHR 690
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-------GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2362-2404 5.34e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.17  E-value: 5.34e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907073704 2362 NLMFWTNWNeLHPSIMRAALSGANVLTLIEKDIRTPNGLAIDH 2404
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2388-2429 5.80e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.80e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  2388 TLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2429
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3631-3665 8.41e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 8.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3631 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3665
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2063-2105 9.73e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 9.73e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  2063 VLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLeTGENR 2105
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3511-3544 9.76e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 9.76e-10
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  3511 TCGVDEFRCKDsGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1398-1441 1.00e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.00e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  1398 TLLAGDIEHPRAIALDPRDGILFWTDWdaSLPRIEAASMSGAGR 1441
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 808-843 1.31e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.10  E-value: 1.31e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704  808 CRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTC 843
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3156-3198 1.38e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.38e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3156 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSlIGRIGMDGSGR 3198
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDV-IEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1033-1066 1.60e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.60e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETH 1066
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2714-2748 1.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.82e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2714 CPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHC 2748
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2752-2783 1.95e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.95e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2783
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 979-1012 2.15e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  979 PLTQFTCNNGRCININWRCDNEKDCGDGSDEKTC 1012
Cdd:cd00112      2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 936-968 2.54e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.54e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   936 TCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 854-886 2.62e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 2.62e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   854 QCQPGEFACANNRCIQERWKCDGDNDCLDNSDE 886
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2018-2061 2.88e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 2.88e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  2018 YVVISQGLDKPRAITVHPEKGYLFWTEWGhYPRIERSRLDGTER 2061
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
1328-1521 4.18e-09

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 4.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1328 ALYWTDVVEDKIYRgklLD--NGALTSFEVViqyGLATPEGLAVDwIAGNIYWVESNLDQIevAKLD---GTLRTTLLAG 1402
Cdd:COG4257     29 AVWFTDQGGGRIGR---LDpaTGEFTEYPLG---GGSGPHGIAVD-PDGNLWFTDNGNNRI--GRIDpktGEITTFALPG 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1403 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASmsgaGRRTIHRETGSGGWPNGLTVDylEKRILWI-DARSDAIysARY 1481
Cdd:COG4257    100 GGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPAT----GEVTEFPLPTGGAGPYGIAVD--PDGNLWVtDFGANAI--GRI 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1482 D-GSGHMEVLRGHEFLSHPFAVTLYG-GEVYWTDWRTNTLAK 1521
Cdd:COG4257    172 DpDTGTLTEYALPTPGAGPRGLAVDPdGNLWVADTGSGRIGR 213
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3671-3703 7.04e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 7.04e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3671 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDE 3703
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1080-1115 1.25e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDEKSC 1115
Cdd:cd00112      1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2835-2867 1.65e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.65e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2835 TCDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3470-3503 1.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.80e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  3470 TCAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDE 3503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 362-402 1.83e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 1.83e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704   362 LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGR 402
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 896-929 2.27e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  896 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESN 929
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1203-1239 2.44e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 2.44e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1203 CSLNNGGCSHNCSVAPGeGIVCSCPLGMELGSDNHTC 1239
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3392-3426 2.66e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 2.66e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3392 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3426
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2875-2908 3.60e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.60e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  2875 TCGPNEFRCANGRCLSsRQWECDGENDCHDHSDE 2908
Cdd:smart00192    1 TCPPGEFQCDNGRCIP-SSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3312-3348 4.31e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 4.31e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3312 CKVNNGGCSNLCLLSPgGGHKCACPTNFYLGGDGRTC 3348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-60 7.81e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 7.81e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704    27 TCSPKQFACRDQiTCISKGWRCDGERDCPDGSDE 60
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3880-4082 8.53e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 8.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3880 AEGSEYQVLYIADDNEIRSLFPGHPHSAYEQTFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISyrslppaAPPTTSNRH 3959
Cdd:COG3391     30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS-------VIDLATGKV 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3960 RRQIDRGvthlnisglKMPRGIAIDWVAGNVYWTDSGRD-VIEVAQMKGENRKTLISGmiDEPHAIVVDPLRGTMYWSDW 4038
Cdd:COG3391    103 VATIPVG---------GGPRGLAVDPDGGRLYVADSGNGrVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANS 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4039 GNHP------KIETAamDGTLRETLvqDNIQWPTGLAVDYHNERLYWADA 4082
Cdd:COG3391    172 GSNTvsvivsVIDTA--TGKVVATI--PVGGGPVGVAVSPDGRRLYVANR 217
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3352-3383 9.58e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.58e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 3352 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 595-634 1.17e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.17e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704   595 ETILKDGIHNVEGVAVDWMGDNLYWTDDGpKKTISVARLE 634
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLD 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2925-2957 1.47e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDERGC 2957
Cdd:cd00112      3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3431-3466 1.47e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3431 CLPSQFKCTNtNRCIPGIFRCNGQDNCGDGEDERDC 3466
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1668-1711 1.81e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.81e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  1668 ETVVSADLPNAHGLAVDWVSRNLFWTsyDTNKKQINVARLDGSF 1711
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWT--DWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3764-3794 1.96e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.96e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3794
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2623-2657 2.70e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 2.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2623 CGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNC 2657
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 317-359 3.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704   317 TLLDLELYNPKGIALDPAMGKVFFTDYGQiPKVERCDMDGQNR 359
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 701-734 3.11e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.11e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704   701 WPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDR 734
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2584-2618 3.77e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.77e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2584 CKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPC 2618
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1122-1158 5.06e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.74  E-value: 5.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDEENC 1158
Cdd:cd00112      1 CPPN-EFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3067-3111 6.05e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.05e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907073704  3067 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQgsMIRRMHLNGSNV 3111
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1752-1793 7.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 7.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  1752 HTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSE 1793
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1715-1752 1.61e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 1.61e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704  1715 VVQGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNH 1752
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 159-189 6.07e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.07e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704  159 GTCSQLCTNTDGSFTCGCVEGYLLQPDNRSC 189
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2791-2824 2.08e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 2.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  2791 TCGPSSFSCPGTHvCVPERWLCDGDKDCTDGADE 2824
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2177-2212 2.45e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2177 CAVANGGCQQLCLYRGGGqRACACAHG-MLAEDGASC 2212
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGyELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 276-315 2.52e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.52e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704   276 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTC 315
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1163-1196 2.68e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 1163 CRPPSHPCANNTsvCLPPDKLCDGKDDCGDGSDE 1196
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 552-594 5.31e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 5.31e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704   552 HMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTER 594
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 120-149 6.46e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 6.46e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073704  120 GCQHHCVPTPSGPTCYCNSSFQLQADGKTC 149
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2545-2575 6.81e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.58  E-value: 6.81e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 2545 QDEFECANGECISFSLTCDGVSHCKDKSDEK 2575
Cdd:cd00112      3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 72-105 7.37e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 7.37e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704    72 RCPPNEHSCLGTElCVPMSRLCNGIQDCMDGSDE 105
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1631-1667 1.16e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 1.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907073704  1631 DIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGV 1667
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3242-3282 1.31e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 1.31e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3242 HVVLSQDIPHI--FALTLFEDYVYWTDWETKSINRAhKTTGAN 3282
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVA-NLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3713-3749 1.44e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3713 CPPNRpFRCKNDRvCLWIGRQCDGVDNCGDGTDEEDC 3749
Cdd:cd00112      1 CPPNE-FRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1868-1904 3.79e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.79e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1868 CSVNNGDCSQLCLPTSEtTRSCMCTAGYSLRSGQQAC 1904
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3000-3029 4.77e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 4.77e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3000 DLDECSTTFPCSQ--LCINTHGSYKCLCVEGY 3029
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2684-2706 1.48e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.73  E-value: 1.48e-03
                           10        20
                   ....*....|....*....|...
gi 1907073704 2684 CYAPSWVCDGANDCGDYSDERDC 2706
Cdd:cd00112     13 CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2500-2532 1.64e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2500 CRINNGGCQDLCLLTHQGHVnCSCRGGRILQED 2532
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDD 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2969-2998 1.99e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 1.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073704 2969 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTC 2998
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 487-520 4.21e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  487 PGGCSDICLlaNSHKARTCRCRSGFSLGSDGKSC 520
Cdd:pfam14670    5 NGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1934-1974 5.35e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 5.35e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1934 VPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR 1974
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2293-2333 7.77e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.77e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  2293 RTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQT 2333
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4031-4072 7.16e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 65.26  E-value: 7.16e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 4031 GTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDY 4072
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3112-3154 2.85e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 2.85e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3112 QVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYR 3154
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1977-2017 3.89e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.39  E-value: 3.89e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1977 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFR 2017
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3200-3241 1.29e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 1.29e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  3200 IIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNR 3241
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3973-4010 3.57e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 3.57e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907073704  3973 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENR 4010
Cdd:smart00135    6 SGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4055-4096 4.14e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.31  E-value: 4.14e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  4055 ETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD 4096
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3593-3627 6.50e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 6.50e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3593 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3627
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3591-3627 1.29e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 1.29e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3591 RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3627
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3554-3588 1.87e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 1.87e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3554 CEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3588
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1354-1394 2.98e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 2.98e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1354 EVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGT 1394
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 641-690 3.77e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 3.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1907073704   641 KTLIEGKMTHPRAIVVDPLNGWMYWTDWeedpkdsRRGRLERAWMDGSHR 690
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-------GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2362-2404 5.34e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.17  E-value: 5.34e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907073704 2362 NLMFWTNWNeLHPSIMRAALSGANVLTLIEKDIRTPNGLAIDH 2404
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2388-2429 5.80e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.80e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  2388 TLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2429
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3631-3665 8.41e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 8.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3631 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3665
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2063-2105 9.73e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 9.73e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  2063 VLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLeTGENR 2105
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3511-3544 9.76e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 9.76e-10
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  3511 TCGVDEFRCKDsGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1398-1441 1.00e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.00e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  1398 TLLAGDIEHPRAIALDPRDGILFWTDWdaSLPRIEAASMSGAGR 1441
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3630-3662 1.09e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.09e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3630 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDE 3662
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 808-843 1.31e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.10  E-value: 1.31e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704  808 CRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTC 843
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3156-3198 1.38e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.38e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3156 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSlIGRIGMDGSGR 3198
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDV-IEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3553-3585 1.52e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 1.52e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3553 TCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDE 3585
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1033-1066 1.60e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.60e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETH 1066
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3512-3544 1.65e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.65e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 3512 CGVDEFRCKDsGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2714-2748 1.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.82e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2714 CPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHC 2748
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1033-1064 1.94e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.94e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1064
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2752-2783 1.95e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.95e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2783
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 979-1012 2.15e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  979 PLTQFTCNNGRCININWRCDNEKDCGDGSDEKTC 1012
Cdd:cd00112      2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 936-968 2.54e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.54e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   936 TCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 854-886 2.62e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 2.62e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   854 QCQPGEFACANNRCIQERWKCDGDNDCLDNSDE 886
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2018-2061 2.88e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 2.88e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  2018 YVVISQGLDKPRAITVHPEKGYLFWTEWGhYPRIERSRLDGTER 2061
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3175-3216 3.29e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 3.29e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 3175 GYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDY 3216
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 937-968 3.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.51e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704  937 CPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2752-2784 3.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.54e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2784
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3552-3588 3.72e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 3.72e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3552 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3588
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1328-1521 4.18e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 4.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1328 ALYWTDVVEDKIYRgklLD--NGALTSFEVViqyGLATPEGLAVDwIAGNIYWVESNLDQIevAKLD---GTLRTTLLAG 1402
Cdd:COG4257     29 AVWFTDQGGGRIGR---LDpaTGEFTEYPLG---GGSGPHGIAVD-PDGNLWFTDNGNNRI--GRIDpktGEITTFALPG 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1403 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASmsgaGRRTIHRETGSGGWPNGLTVDylEKRILWI-DARSDAIysARY 1481
Cdd:COG4257    100 GGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPAT----GEVTEFPLPTGGAGPYGIAVD--PDGNLWVtDFGANAI--GRI 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1482 D-GSGHMEVLRGHEFLSHPFAVTLYG-GEVYWTDWRTNTLAK 1521
Cdd:COG4257    172 DpDTGTLTEYALPTPGAGPRGLAVDPdGNLWVADTGSGRIGR 213
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 855-887 5.39e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 5.39e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704  855 CQPGEFACANNRCIQERWKCDGDNDCLDNSDEA 887
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3593-3624 5.56e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 5.56e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3593 CSESEFSCANGRCIAGRWKCDGDHDCADGSDE 3624
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3671-3703 7.04e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 7.04e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3671 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDE 3703
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4011-4052 7.59e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 7.59e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  4011 KTLISGMIDEPHAIVVDPLRGTMYWSDWGnHPKIETAAMDGT 4052
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1080-1115 1.25e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDEKSC 1115
Cdd:cd00112      1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3672-3704 1.30e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.30e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 3672 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDEN 3704
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2835-2867 1.65e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.65e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2835 TCDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3470-3503 1.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.80e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  3470 TCAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDE 3503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 362-402 1.83e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 1.83e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704   362 LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGR 402
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3630-3665 1.87e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 1.87e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3630 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3665
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3511-3544 2.23e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 3511 TCGVDEFRCKdSGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:pfam00057    2 TCSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1033-1069 2.25e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDEthANC 1069
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 896-929 2.27e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  896 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESN 929
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1203-1239 2.44e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 2.44e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1203 CSLNNGGCSHNCSVAPGeGIVCSCPLGMELGSDNHTC 1239
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
935-968 2.46e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  935 RTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2038-2079 2.50e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.50e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 2038 GYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDY 2079
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 895-927 2.61e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.61e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   895 TCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDE 927
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3392-3426 2.66e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 2.66e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3392 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3426
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2713-2745 3.60e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.60e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2713 RCPLNYFACPSGRCIPMSWTCDKEDDCENGEDE 2745
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2875-2908 3.60e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.60e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  2875 TCGPNEFRCANGRCLSsRQWECDGENDCHDHSDE 2908
Cdd:smart00192    1 TCPPGEFQCDNGRCIP-SSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
854-887 4.22e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 4.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  854 QCQPGEFACANNRCIQERWKCDGDNDCLDNSDEA 887
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3312-3348 4.31e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 4.31e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3312 CKVNNGGCSNLCLLSPgGGHKCACPTNFYLGGDGRTC 3348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1080-1112 4.69e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 4.69e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDE 1112
Cdd:smart00192    2 CPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3966-4133 4.87e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 4.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3966 GVTHLNISGLKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTL-----ISGMIDEPHAIVVDPlRGTMYWSDWGN 4040
Cdd:cd05819     92 GGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4041 HpKI-----ETAAMDGTLRETLVQDNIQWPTGLAVDYhNERLYWADAKLSVIGSIRLNGTDPIVA---ADSKRGLSHPFS 4112
Cdd:cd05819    170 H-RIqvfdpDGNFLTTFGSTGTGPGQFNYPTGIAVDS-DGNIYVADSGNNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSG 247

                          170       180
                   ....*....|....*....|..
gi 1907073704 4113 IDVFED-YIYGVTYINNRVFKI 4133
Cdd:cd05819    248 LAVDSDgNLYVADTGNNRIQVF 269
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 979-1009 6.68e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 6.68e-08
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907073704   979 PLTQFTCNNGRCININWRCDNEKDCGDGSDE 1009
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-60 7.81e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 7.81e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704    27 TCSPKQFACRDQiTCISKGWRCDGERDCPDGSDE 60
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2876-2909 8.43e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 8.43e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 2876 CGPNEFRCANGRCLSSRqWECDGENDCHDHSDEA 2909
Cdd:cd00112      1 CPPNEFRCANGRCIPSS-WVCDGEDDCGDGSDEE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3880-4082 8.53e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 8.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3880 AEGSEYQVLYIADDNEIRSLFPGHPHSAYEQTFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISyrslppaAPPTTSNRH 3959
Cdd:COG3391     30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS-------VIDLATGKV 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3960 RRQIDRGvthlnisglKMPRGIAIDWVAGNVYWTDSGRD-VIEVAQMKGENRKTLISGmiDEPHAIVVDPLRGTMYWSDW 4038
Cdd:COG3391    103 VATIPVG---------GGPRGLAVDPDGGRLYVADSGNGrVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANS 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4039 GNHP------KIETAamDGTLRETLvqDNIQWPTGLAVDYHNERLYWADA 4082
Cdd:COG3391    172 GSNTvsvivsVIDTA--TGKVVATI--PVGGGPVGVAVSPDGRRLYVANR 217
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3352-3383 9.58e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.58e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 3352 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2875-2909 9.69e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 9.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2875 TCGPNEFRCANGRCLSsRQWECDGENDCHDHSDEA 2909
Cdd:pfam00057    2 TCSPNEFQCGSGECIP-RSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2836-2867 9.86e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.86e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 2836 CDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3352-3383 9.88e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.88e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3352 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3471-3507 1.09e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3471 CAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDEpANC 3507
Cdd:cd00112      1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 595-634 1.17e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.17e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704   595 ETILKDGIHNVEGVAVDWMGDNLYWTDDGpKKTISVARLE 634
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLD 39
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1924-2140 1.35e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 56.18  E-value: 1.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1924 LDPNDKSDALVPVSGTSLAVGIDFhAENDTIYWVDMGLSTIsrakrdqtWREDVVTNGIGRVE---------GIAVDwIA 1994
Cdd:COG4257     43 LDPATGEFTEYPLGGGSGPHGIAV-DPDGNLWFTDNGNNRI--------GRIDPKTGEITTFAlpgggsnphGIAFD-PD 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1995 GNIYWTDQGFDVIevARLN---GSFRYVVISQGLDKPRAITVHPeKGYLFWTEWG--HYPRIERSrlDGTERVVLVNVSI 2069
Cdd:COG4257    113 GNLWFTDQGGNRI--GRLDpatGEVTEFPLPTGGAGPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPTPG 187

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907073704 2070 SWPNGISVDYQGgKLYWCDARMDKIERIDLETGENREVVLSSNNMDMFSVSV-FEDFIYWSDrtHANGSIKR 2140
Cdd:COG4257    188 AGPRGLAVDPDG-NLWVADTGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVdGDGRVWFAE--SGANRIVR 256
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2925-2957 1.47e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDERGC 2957
Cdd:cd00112      3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3431-3466 1.47e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3431 CLPSQFKCTNtNRCIPGIFRCNGQDNCGDGEDERDC 3466
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3469-3507 1.69e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.69e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907073704 3469 VTCAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDEpANC 3507
Cdd:pfam00057    1 STCSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDE-ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-61 1.76e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.76e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704   28 CSPKQFACRDQiTCISKGWRCDGERDCPDGSDEA 61
Cdd:cd00112      1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1668-1711 1.81e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.81e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  1668 ETVVSADLPNAHGLAVDWVSRNLFWTsyDTNKKQINVARLDGSF 1711
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWT--DWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1080-1115 1.92e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDEKSC 1115
Cdd:pfam00057    3 CSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3764-3794 1.96e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.96e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3794
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1374-1414 2.18e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1374 GNIYWVESNLDQ-IEVAKLDGTLRTTLLAGDIEHPRAIALDP 1414
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
895-929 2.27e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 2.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704  895 TCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESN 929
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3391-3423 2.31e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.31e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3391 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDE 3423
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1995-2035 2.47e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.47e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1995 GNIYWTDQGFD-VIEVARLNGSFRYVVISQGLDKPRAITVHP 2035
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2623-2657 2.70e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 2.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2623 CGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNC 2657
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
982-1012 2.79e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 2.79e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704  982 QFTCNNGRCININWRCDNEKDCGDGSDEKTC 1012
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3988-4028 3.07e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 3988 GNVYWTDSG-RDVIEVAQMKGENRKTLISGMIDEPHAIVVDP 4028
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 317-359 3.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704   317 TLLDLELYNPKGIALDPAMGKVFFTDYGQiPKVERCDMDGQNR 359
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 701-734 3.11e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.11e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704   701 WPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDR 734
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1442-1486 3.26e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.26e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907073704  1442 RTIHREtgSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGH 1486
Cdd:smart00135    1 RTLLSS--GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3391-3426 3.30e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 3.30e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3391 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3426
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2584-2618 3.77e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.77e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2584 CKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPC 2618
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3975-4133 3.82e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.02  E-value: 3.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3975 LKMPRGIAIDwVAGNVYWTDSGRDVIEV-------AQMKGENRKTLisGMIDEPHAIVVDPlRGTMYWSDWGNHpKIETA 4047
Cdd:cd05819      7 LNNPQGIAVD-SSGNIYVADTGNNRIQVfdpdgnfITSFGSFGSGD--GQFNEPAGVAVDS-DGNLYVADTGNH-RIQKF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4048 AMDGTLRETLV-----QDNIQWPTGLAVDyHNERLYWADAKLSVIGSIRLNGTdPIVAADSK----RGLSHPFSIDVF-E 4117
Cdd:cd05819     82 DPDGNFLASFGgsgdgDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE-FLTTFGSGgsgpGQFNGPTGVAVDsD 159

                          170
                   ....*....|....*.
gi 1907073704 4118 DYIYGVTYINNRVFKI 4133
Cdd:cd05819    160 GNIYVADTGNHRIQVF 175
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2752-2784 4.01e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 4.01e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2784
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1122-1158 5.06e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.74  E-value: 5.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDEENC 1158
Cdd:cd00112      1 CPPN-EFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3670-3703 5.82e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 5.82e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 3670 RTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDE 3703
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3067-3111 6.05e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.05e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907073704  3067 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQgsMIRRMHLNGSNV 3111
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1752-1793 7.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 7.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  1752 HTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSE 1793
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2583-2615 7.95e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 7.95e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2583 RCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDE 2615
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1715-1752 1.61e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 1.61e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704  1715 VVQGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNH 1752
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
26-61 1.64e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 1.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704   26 KTCSPKQFACRDQiTCISKGWRCDGERDCPDGSDEA 61
Cdd:pfam00057    1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2713-2748 1.73e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 1.73e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 2713 RCPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHC 2748
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1122-1158 2.02e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDEENC 1158
Cdd:pfam00057    3 CSPN-EFQCGSG-ECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2925-2954 4.42e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.42e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907073704  2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDE 2954
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3431-3463 4.55e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.55e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3431 CLPSQFKCTNtNRCIPGIFRCNGQDNCGDGEDE 3463
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2621-2657 4.93e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2621 TACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNC 2657
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 159-189 6.07e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.07e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704  159 GTCSQLCTNTDGSFTCGCVEGYLLQPDNRSC 189
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2623-2654 9.87e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 9.87e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  2623 CGVGEFRCRDGSCIGNSSRCNQFVDCEDASDE 2654
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2834-2867 1.01e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 2834 STCDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3219-3259 1.52e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.84  E-value: 1.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 3219 ERIYWADAREDY-IEFASLDGSNRHVVLSQDIPHIFALTLFE 3259
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3431-3466 1.97e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 1.97e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3431 CLPSQFKCtNTNRCIPGIFRCNGQDNCGDGEDERDC 3466
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2791-2824 2.08e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 2.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  2791 TCGPSSFSCPGTHvCVPERWLCDGDKDCTDGADE 2824
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2925-2957 2.37e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 2.37e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDERGC 2957
Cdd:pfam00057    5 PNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 663-709 2.39e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 2.39e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907073704  663 MYWTDWEEDPKdsrrgrLERAWMDGSHRDIFVTSKtVLWPNGLSLDI 709
Cdd:pfam00058    3 LYWTDSSLRAS------ISSADLNGSDRKTLFTDD-LQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2177-2212 2.45e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2177 CAVANGGCQQLCLYRGGGqRACACAHG-MLAEDGASC 2212
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGyELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 276-315 2.52e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.52e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704   276 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTC 315
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1163-1196 2.68e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 1163 CRPPSHPCANNTsvCLPPDKLCDGKDDCGDGSDE 1196
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3764-3791 2.76e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.76e-05
                            10        20
                    ....*....|....*....|....*...
gi 1907073704  3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDE 3791
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1163-1196 2.99e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.99e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  1163 CRPPSHPCANNTsvCLPPDKLCDGKDDCGDGSDE 1196
Cdd:smart00192    2 CPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1122-1155 3.78e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.78e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDE 1155
Cdd:smart00192    2 CPPG-EFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2792-2824 4.25e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.25e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2792 CGPSSFSCpGTHVCVPERWLCDGDKDCTDGADE 2824
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 552-594 5.31e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 5.31e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704   552 HMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTER 594
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 120-149 6.46e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 6.46e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073704  120 GCQHHCVPTPSGPTCYCNSSFQLQADGKTC 149
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2545-2575 6.81e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.58  E-value: 6.81e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 2545 QDEFECANGECISFSLTCDGVSHCKDKSDEK 2575
Cdd:cd00112      3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 72-105 7.37e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 7.37e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704    72 RCPPNEHSCLGTElCVPMSRLCNGIQDCMDGSDE 105
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2790-2824 7.62e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 7.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2790 KTCGPSSFSCpGTHVCVPERWLCDGDKDCTDGADE 2824
Cdd:pfam00057    1 STCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
72-109 8.16e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 8.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907073704   72 RCPPNEHSCLGTElCVPMSRLCNGIQDCMDGSDEgAHC 109
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDE-ENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1631-1667 1.16e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 1.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907073704  1631 DIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGV 1667
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 73-105 1.23e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.23e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704   73 CPPNEHSClGTELCVPMSRLCNGIQDCMDGSDE 105
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1645-1685 1.30e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 1.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1645 QRVYWSDVRTQA-IKRAFINGTGVETVVSADLPNAHGLAVDW 1685
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3242-3282 1.31e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 1.31e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3242 HVVLSQDIPHI--FALTLFEDYVYWTDWETKSINRAhKTTGAN 3282
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVA-NLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3713-3749 1.44e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3713 CPPNRpFRCKNDRvCLWIGRQCDGVDNCGDGTDEEDC 3749
Cdd:cd00112      1 CPPNE-FRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1419-1461 1.65e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 1.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907073704 1419 LFWTDWdaSL-PRIEAASMSGAGRRTIHreTGSGGWPNGLTVDY 1461
Cdd:pfam00058    3 LYWTDS--SLrASISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2545-2574 1.89e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.89e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907073704  2545 QDEFECANGECISFSLTCDGVSHCKDKSDE 2574
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 141-188 3.27e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 3.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1907073704  141 QLQadGKTCKDFDECSVYG-TCSQLCTNTDGSFTCGCVEGYLLQPDNRS 188
Cdd:cd01475    178 KFQ--GKICVVPDLCATLShVCQQVCISTPGSYLCACTEGYALLEDNKT 224
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3764-3794 3.29e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.29e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3794
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2582-2618 3.56e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2582 RRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPC 2618
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1868-1904 3.79e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.79e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1868 CSVNNGDCSQLCLPTSEtTRSCMCTAGYSLRSGQQAC 1904
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3350-3383 3.81e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 3350 SNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3975-4041 4.18e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.74  E-value: 4.18e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907073704 3975 LKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTLIS-----GMIDEPHAIVVDPlRGTMYWSDWGNH 4041
Cdd:cd14956    200 FNYPYGIAID-PDGNVFVADFGNNRIQKFTADGTFLTSWGSpgtgpGQFKNPWGVVVDA-DGTVYVADSNNN 269
EGF_CA smart00179
Calcium-binding EGF-like domain;
3000-3029 4.77e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 4.77e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3000 DLDECSTTFPCSQ--LCINTHGSYKCLCVEGY 3029
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3132-3171 5.12e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 5.12e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 3132 GNLYWCDKG-RDTIEVSKLNGAYRTVLVSSGLREPRALVVD 3171
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3000-3029 6.75e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 6.75e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 3000 DLDECSTTFPCS--QLCINTHGSYKCLCVEGY 3029
Cdd:cd00054      1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3089-3129 8.70e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 8.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 3089 IYWTDVTTQGSmIRRMHLNGSNVQVLHRTGLSNPDGLAVDW 3129
Cdd:pfam00058    3 LYWTDSSLRAS-ISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1294-1478 9.52e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.50  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1294 RHEIRRIDLHKGDYSVLVPGLRNT------IALDfhlSQSALYWTDVVEDKIYRgklLDNGALtsFEVVIQYGLAT--PE 1365
Cdd:cd14962     32 RGAVFVFDLPNGKVFVIGNAGPNRfvspigVAID---ANGNLYVSDAELGKVFV---FDRDGK--FLRAIGAGALFkrPT 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1366 GLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTL-----LAGDIEHPRAIALDpRDGILFWTdwDASLPRIEAASMSGAG 1440
Cdd:cd14962    104 GIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIgkrgsGPGEFNLPTDLAVD-RDGNLYVT--DTMNFRVQIFDADGKF 180

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1907073704 1441 RRTI-HRETGSGGW--PNGLTVDYlEKRILWIDARSDA--IYS 1478
Cdd:cd14962    181 LRSFgERGDGPGSFarPKGIAVDS-EGNIYVVDAAFDNvqIFN 222
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2540-2575 1.07e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.15  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 2540 SSCRAqDEFECANGECISFSLTCDGVSHCKDKSDEK 2575
Cdd:pfam00057    1 STCSP-NEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2684-2706 1.48e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.73  E-value: 1.48e-03
                           10        20
                   ....*....|....*....|...
gi 1907073704 2684 CYAPSWVCDGANDCGDYSDERDC 2706
Cdd:cd00112     13 CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2500-2532 1.64e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2500 CRINNGGCQDLCLLTHQGHVnCSCRGGRILQED 2532
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDD 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2969-2998 1.99e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 1.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073704 2969 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTC 2998
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2341-2386 2.79e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1907073704  2341 ETVITmSGDDHPRAFVLDECQNLMFWTNWNelHPSIMRAALSGANV 2386
Cdd:smart00135    1 RTLLS-SGLGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2407-2446 3.04e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 3.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 2407 EKLYFSDATLD-KIERCEYDGSHRYVILKSEPVHPFGLAVY 2446
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 487-520 4.21e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  487 PGGCSDICLlaNSHKARTCRCRSGFSLGSDGKSC 520
Cdd:pfam14670    5 NGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1732-1768 4.46e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 4.46e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1732 GKLYWTDGDN---ISMANMDGSNHTLLFS--GQKgPVGLAID 1768
Cdd:pfam00058    1 GRLYWTDSSLrasISSADLNGSDRKTLFTddLQH-PNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2680-2706 5.12e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 5.12e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907073704 2680 RTSLCYAPSWVCDGANDCGDYSDERDC 2706
Cdd:pfam00057   11 GSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1934-1974 5.35e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 5.35e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1934 VPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR 1974
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 336-376 6.48e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 6.48e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704  336 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLD 376
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2293-2333 7.77e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.77e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  2293 RTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQT 2333
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
151-180 9.97e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 9.97e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704   151 DFDECSVYGTCSQ--LCTNTDGSFTCGCVEGY 180
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4031-4072 7.16e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 65.26  E-value: 7.16e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 4031 GTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDY 4072
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3112-3154 2.85e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 2.85e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3112 QVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYR 3154
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1977-2017 3.89e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.39  E-value: 3.89e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1977 VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFR 2017
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3200-3241 1.29e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 1.29e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  3200 IIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNR 3241
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3973-4010 3.57e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 3.57e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907073704  3973 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENR 4010
Cdd:smart00135    6 SGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4055-4096 4.14e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.31  E-value: 4.14e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  4055 ETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD 4096
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3593-3627 6.50e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 6.50e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3593 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3627
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3591-3627 1.29e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 1.29e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3591 RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3627
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3554-3588 1.87e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 1.87e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3554 CEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3588
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1354-1394 2.98e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 2.98e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1354 EVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGT 1394
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 641-690 3.77e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 3.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1907073704   641 KTLIEGKMTHPRAIVVDPLNGWMYWTDWeedpkdsRRGRLERAWMDGSHR 690
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-------GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2362-2404 5.34e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.17  E-value: 5.34e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907073704 2362 NLMFWTNWNeLHPSIMRAALSGANVLTLIEKDIRTPNGLAIDH 2404
Cdd:pfam00058    1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2388-2429 5.80e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.80e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  2388 TLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHR 2429
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3631-3665 8.41e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 8.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3631 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3665
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2063-2105 9.73e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 9.73e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  2063 VLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLeTGENR 2105
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3511-3544 9.76e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 9.76e-10
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  3511 TCGVDEFRCKDsGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1398-1441 1.00e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.00e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  1398 TLLAGDIEHPRAIALDPRDGILFWTDWdaSLPRIEAASMSGAGR 1441
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3630-3662 1.09e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.09e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3630 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDE 3662
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 808-843 1.31e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.10  E-value: 1.31e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704  808 CRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTC 843
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3156-3198 1.38e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.38e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3156 VLVSSGLREPRALVVDVQNGYLYWTDWGDHSlIGRIGMDGSGR 3198
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDV-IEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3553-3585 1.52e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 1.52e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3553 TCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDE 3585
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1033-1066 1.60e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.60e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETH 1066
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3512-3544 1.65e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.65e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 3512 CGVDEFRCKDsGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2714-2748 1.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.82e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2714 CPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHC 2748
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1033-1064 1.94e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.94e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1064
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2752-2783 1.95e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 1.95e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2783
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 979-1012 2.15e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  979 PLTQFTCNNGRCININWRCDNEKDCGDGSDEKTC 1012
Cdd:cd00112      2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 936-968 2.54e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.54e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   936 TCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 854-886 2.62e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 2.62e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   854 QCQPGEFACANNRCIQERWKCDGDNDCLDNSDE 886
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2018-2061 2.88e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 2.88e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  2018 YVVISQGLDKPRAITVHPEKGYLFWTEWGhYPRIERSRLDGTER 2061
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3175-3216 3.29e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 3.29e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 3175 GYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDY 3216
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 937-968 3.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.51e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704  937 CPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2752-2784 3.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.54e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2784
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3552-3588 3.72e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 3.72e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3552 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3588
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1328-1521 4.18e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 4.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1328 ALYWTDVVEDKIYRgklLD--NGALTSFEVViqyGLATPEGLAVDwIAGNIYWVESNLDQIevAKLD---GTLRTTLLAG 1402
Cdd:COG4257     29 AVWFTDQGGGRIGR---LDpaTGEFTEYPLG---GGSGPHGIAVD-PDGNLWFTDNGNNRI--GRIDpktGEITTFALPG 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1403 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASmsgaGRRTIHRETGSGGWPNGLTVDylEKRILWI-DARSDAIysARY 1481
Cdd:COG4257    100 GGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPAT----GEVTEFPLPTGGAGPYGIAVD--PDGNLWVtDFGANAI--GRI 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1482 D-GSGHMEVLRGHEFLSHPFAVTLYG-GEVYWTDWRTNTLAK 1521
Cdd:COG4257    172 DpDTGTLTEYALPTPGAGPRGLAVDPdGNLWVADTGSGRIGR 213
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 855-887 5.39e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 5.39e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704  855 CQPGEFACANNRCIQERWKCDGDNDCLDNSDEA 887
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3593-3624 5.56e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 5.56e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3593 CSESEFSCANGRCIAGRWKCDGDHDCADGSDE 3624
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3671-3703 7.04e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 7.04e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3671 TCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDE 3703
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4011-4052 7.59e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.14  E-value: 7.59e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  4011 KTLISGMIDEPHAIVVDPLRGTMYWSDWGnHPKIETAAMDGT 4052
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGT 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1080-1115 1.25e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDEKSC 1115
Cdd:cd00112      1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3672-3704 1.30e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.30e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 3672 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDEN 3704
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2835-2867 1.65e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.65e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2835 TCDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3470-3503 1.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.80e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  3470 TCAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDE 3503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 362-402 1.83e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 1.83e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704   362 LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGR 402
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3630-3665 1.87e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 1.87e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3630 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3665
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3511-3544 2.23e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 3511 TCGVDEFRCKdSGRCIPARWKCDGEDDCGDGSDE 3544
Cdd:pfam00057    2 TCSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1033-1069 2.25e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1033 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDEthANC 1069
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 896-929 2.27e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.27e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  896 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESN 929
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1203-1239 2.44e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 2.44e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1203 CSLNNGGCSHNCSVAPGeGIVCSCPLGMELGSDNHTC 1239
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
935-968 2.46e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  935 RTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 968
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2038-2079 2.50e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.50e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 2038 GYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDY 2079
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 895-927 2.61e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.61e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704   895 TCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDE 927
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3392-3426 2.66e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 2.66e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 3392 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3426
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2713-2745 3.60e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.60e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2713 RCPLNYFACPSGRCIPMSWTCDKEDDCENGEDE 2745
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2875-2908 3.60e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.60e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  2875 TCGPNEFRCANGRCLSsRQWECDGENDCHDHSDE 2908
Cdd:smart00192    1 TCPPGEFQCDNGRCIP-SSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
854-887 4.22e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 4.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  854 QCQPGEFACANNRCIQERWKCDGDNDCLDNSDEA 887
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3312-3348 4.31e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 4.31e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3312 CKVNNGGCSNLCLLSPgGGHKCACPTNFYLGGDGRTC 3348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1080-1112 4.69e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 4.69e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDE 1112
Cdd:smart00192    2 CPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3966-4133 4.87e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 4.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3966 GVTHLNISGLKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTL-----ISGMIDEPHAIVVDPlRGTMYWSDWGN 4040
Cdd:cd05819     92 GGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4041 HpKI-----ETAAMDGTLRETLVQDNIQWPTGLAVDYhNERLYWADAKLSVIGSIRLNGTDPIVA---ADSKRGLSHPFS 4112
Cdd:cd05819    170 H-RIqvfdpDGNFLTTFGSTGTGPGQFNYPTGIAVDS-DGNIYVADSGNNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSG 247

                          170       180
                   ....*....|....*....|..
gi 1907073704 4113 IDVFED-YIYGVTYINNRVFKI 4133
Cdd:cd05819    248 LAVDSDgNLYVADTGNNRIQVF 269
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 979-1009 6.68e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 6.68e-08
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907073704   979 PLTQFTCNNGRCININWRCDNEKDCGDGSDE 1009
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-60 7.81e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 7.81e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704    27 TCSPKQFACRDQiTCISKGWRCDGERDCPDGSDE 60
Cdd:smart00192    1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2876-2909 8.43e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 8.43e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 2876 CGPNEFRCANGRCLSSRqWECDGENDCHDHSDEA 2909
Cdd:cd00112      1 CPPNEFRCANGRCIPSS-WVCDGEDDCGDGSDEE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3880-4082 8.53e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 8.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3880 AEGSEYQVLYIADDNEIRSLFPGHPHSAYEQTFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISyrslppaAPPTTSNRH 3959
Cdd:COG3391     30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS-------VIDLATGKV 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3960 RRQIDRGvthlnisglKMPRGIAIDWVAGNVYWTDSGRD-VIEVAQMKGENRKTLISGmiDEPHAIVVDPLRGTMYWSDW 4038
Cdd:COG3391    103 VATIPVG---------GGPRGLAVDPDGGRLYVADSGNGrVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANS 171

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4039 GNHP------KIETAamDGTLRETLvqDNIQWPTGLAVDYHNERLYWADA 4082
Cdd:COG3391    172 GSNTvsvivsVIDTA--TGKVVATI--PVGGGPVGVAVSPDGRRLYVANR 217
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3352-3383 9.58e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.58e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 3352 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2875-2909 9.69e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 9.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2875 TCGPNEFRCANGRCLSsRQWECDGENDCHDHSDEA 2909
Cdd:pfam00057    2 TCSPNEFQCGSGECIP-RSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2836-2867 9.86e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.86e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 2836 CDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3352-3383 9.88e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.88e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3352 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1293-1426 9.97e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 56.57  E-value: 9.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1293 NRHEIRRIDLHKGDYSVLVPGLRNT----IALDfhlSQSALYWTDVVEDKIyrGKL-LDNGALTSFEVVIQygLATPEGL 1367
Cdd:COG4257    121 GGNRIGRLDPATGEVTEFPLPTGGAgpygIAVD---PDGNLWVTDFGANAI--GRIdPDTGTLTEYALPTP--GAGPRGL 193

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907073704 1368 AVDwIAGNIYWVESNLDQIevAKLD---GTLRTTLLAGDIEHPRAIALDPrDGILFWTDWDA 1426
Cdd:COG4257    194 AVD-PDGNLWVADTGSGRI--GRFDpktGTVTEYPLPGGGARPYGVAVDG-DGRVWFAESGA 251
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3471-3507 1.09e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3471 CAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDEpANC 3507
Cdd:cd00112      1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 595-634 1.17e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.17e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704   595 ETILKDGIHNVEGVAVDWMGDNLYWTDDGpKKTISVARLE 634
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLD 39
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1924-2140 1.35e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 56.18  E-value: 1.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1924 LDPNDKSDALVPVSGTSLAVGIDFhAENDTIYWVDMGLSTIsrakrdqtWREDVVTNGIGRVE---------GIAVDwIA 1994
Cdd:COG4257     43 LDPATGEFTEYPLGGGSGPHGIAV-DPDGNLWFTDNGNNRI--------GRIDPKTGEITTFAlpgggsnphGIAFD-PD 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1995 GNIYWTDQGFDVIevARLN---GSFRYVVISQGLDKPRAITVHPeKGYLFWTEWG--HYPRIERSrlDGTERVVLVNVSI 2069
Cdd:COG4257    113 GNLWFTDQGGNRI--GRLDpatGEVTEFPLPTGGAGPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPTPG 187

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907073704 2070 SWPNGISVDYQGgKLYWCDARMDKIERIDLETGENREVVLSSNNMDMFSVSV-FEDFIYWSDrtHANGSIKR 2140
Cdd:COG4257    188 AGPRGLAVDPDG-NLWVADTGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVdGDGRVWFAE--SGANRIVR 256
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2925-2957 1.47e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDERGC 2957
Cdd:cd00112      3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3431-3466 1.47e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3431 CLPSQFKCTNtNRCIPGIFRCNGQDNCGDGEDERDC 3466
Cdd:cd00112      1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3469-3507 1.69e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.69e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907073704 3469 VTCAPNQFQCSiTKRCIPRVWVCDRDNDCVDGSDEpANC 3507
Cdd:pfam00057    1 STCSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDE-ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-61 1.76e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.76e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704   28 CSPKQFACRDQiTCISKGWRCDGERDCPDGSDEA 61
Cdd:cd00112      1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1668-1711 1.81e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.81e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907073704  1668 ETVVSADLPNAHGLAVDWVSRNLFWTsyDTNKKQINVARLDGSF 1711
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWT--DWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1080-1115 1.92e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 1080 CHSDEFQCRlDGLCIPLRWRCDGDTDCMDSSDEKSC 1115
Cdd:pfam00057    3 CSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3764-3794 1.96e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.96e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3794
Cdd:cd00112      5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1374-1414 2.18e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1374 GNIYWVESNLDQ-IEVAKLDGTLRTTLLAGDIEHPRAIALDP 1414
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
895-929 2.27e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 2.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704  895 TCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESN 929
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3391-3423 2.31e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.31e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3391 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDE 3423
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1995-2035 2.47e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.47e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1995 GNIYWTDQGFD-VIEVARLNGSFRYVVISQGLDKPRAITVHP 2035
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2623-2657 2.70e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 2.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2623 CGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNC 2657
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
982-1012 2.79e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 2.79e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704  982 QFTCNNGRCININWRCDNEKDCGDGSDEKTC 1012
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3988-4028 3.07e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 3988 GNVYWTDSG-RDVIEVAQMKGENRKTLISGMIDEPHAIVVDP 4028
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 317-359 3.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704   317 TLLDLELYNPKGIALDPAMGKVFFTDYGQiPKVERCDMDGQNR 359
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 701-734 3.11e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.11e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704   701 WPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDR 734
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1442-1486 3.26e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.26e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907073704  1442 RTIHREtgSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGH 1486
Cdd:smart00135    1 RTLLSS--GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3391-3426 3.30e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 3.30e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3391 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3426
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2584-2618 3.77e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.77e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2584 CKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPC 2618
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3975-4133 3.82e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.02  E-value: 3.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3975 LKMPRGIAIDwVAGNVYWTDSGRDVIEV-------AQMKGENRKTLisGMIDEPHAIVVDPlRGTMYWSDWGNHpKIETA 4047
Cdd:cd05819      7 LNNPQGIAVD-SSGNIYVADTGNNRIQVfdpdgnfITSFGSFGSGD--GQFNEPAGVAVDS-DGNLYVADTGNH-RIQKF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4048 AMDGTLRETLV-----QDNIQWPTGLAVDyHNERLYWADAKLSVIGSIRLNGTdPIVAADSK----RGLSHPFSIDVF-E 4117
Cdd:cd05819     82 DPDGNFLASFGgsgdgDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE-FLTTFGSGgsgpGQFNGPTGVAVDsD 159

                          170
                   ....*....|....*.
gi 1907073704 4118 DYIYGVTYINNRVFKI 4133
Cdd:cd05819    160 GNIYVADTGNHRIQVF 175
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2752-2784 4.01e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 4.01e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2752 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEA 2784
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1122-1158 5.06e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.74  E-value: 5.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDEENC 1158
Cdd:cd00112      1 CPPN-EFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3670-3703 5.82e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 5.82e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 3670 RTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDE 3703
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3067-3111 6.05e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.05e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907073704  3067 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQgsMIRRMHLNGSNV 3111
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1752-1793 7.08e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 7.08e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907073704  1752 HTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSE 1793
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2583-2615 7.95e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 7.95e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  2583 RCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDE 2615
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3089-3226 7.97e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.86  E-value: 7.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3089 IYWTDvtTQGSMIRRMHLNGSNVQVLHRTG-----LSNPDGLAVDWVGgNLYWCDKGRDTIEVSKLNGAYRTVLVSSG-- 3161
Cdd:cd05819    115 IYVAD--TGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGNFLTTFGSTGtg 191

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907073704 3162 ---LREPRALVVDvQNGYLYWTDWGDH-----SLIGRIGmDGSGRSIIVDTKITWPNGLTVDyVTERIYWADA 3226
Cdd:cd05819    192 pgqFNYPTGIAVD-SDGNIYVADSGNNrvqvfDPDGAGF-GGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADT 261
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1715-1752 1.61e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 1.61e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704  1715 VVQGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNH 1752
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDwgLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
26-61 1.64e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 1.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704   26 KTCSPKQFACRDQiTCISKGWRCDGERDCPDGSDEA 61
Cdd:pfam00057    1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2713-2748 1.73e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 1.73e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 2713 RCPLNYFACPSGRCIPMSWTCDKEDDCENGEDETHC 2748
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1122-1158 2.02e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDEENC 1158
Cdd:pfam00057    3 CSPN-EFQCGSG-ECIPRSWVCDGDPDCGDGSDEENC 37
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 3085-3225 2.20e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 52.59  E-value: 2.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3085 REQMIYWTDVTTQGsmIRRMHLNGSNVQVLHRT-GLSNpdGLAVDWvGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLR 3163
Cdd:COG3386     17 PDGRLYWVDIPGGR--IHRYDPDGGAVEVFAEPsGRPN--GLAFDP-DGRLLVADHGRGLVRFDPADGEVTVLADEYGKP 91

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907073704 3164 EPRA--LVVDvQNGYLYWTDWGDHSLIGRIGM-DGSGRSIIVDTKITWPNGLTVDYVTERIYWAD 3225
Cdd:COG3386     92 LNRPndGVVD-PDGRLYFTDMGEYLPTGALYRvDPDGSLRVLADGLTFPNGIAFSPDGRTLYVAD 155
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3120-3229 3.56e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 3.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3120 SNPDGLAVDWVGGNLYWCDKGRDTieVSKLNGAYRTVL--VSSGlREPRALVVDVQNGYLYWTDWGDHS---LIGRIgmD 3194
Cdd:COG3391    110 GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVatIPVG-AGPHGIAVDPDGKRLYVANSGSNTvsvIVSVI--D 184

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907073704 3195 GSGRSII--VDTKITwPNGLTVDYVTERIYWADARED 3229
Cdd:COG3391    185 TATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
3974-4133 3.94e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.94  E-value: 3.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3974 GLKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPlRGTMYWSDWGNH------PKieta 4047
Cdd:COG4257     15 PGSGPRDVAVD-PDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNrigridPK---- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4048 amDGTLRETLVQDNIQWPTGLAVDyHNERLYWADAKLSVIGSIRLNgTDPIVAADSKRGLSHPFSIDV-FEDYIYGVTYI 4126
Cdd:COG4257     89 --TGEITTFALPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPA-TGEVTEFPLPTGGAGPYGIAVdPDGNLWVTDFG 164


                   ....*..
gi 1907073704 4127 NNRVFKI 4133
Cdd:COG4257    165 ANAIGRI 171
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2925-2954 4.42e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.42e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907073704  2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDE 2954
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3431-3463 4.55e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.55e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907073704  3431 CLPSQFKCTNtNRCIPGIFRCNGQDNCGDGEDE 3463
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2621-2657 4.93e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2621 TACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNC 2657
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 159-189 6.07e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 6.07e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704  159 GTCSQLCTNTDGSFTCGCVEGYLLQPDNRSC 189
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1309-1533 6.83e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 6.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1309 VLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVeSNLDQIEV 1388
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYV-ANSGSGRV 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1389 AKLD---GTLRTTLLAGDieHPRAIALDPRDGILFWTDW-DASLPRIEAASMsgagrrTIHRETGSGGWPNGLTVDYLEK 1464
Cdd:COG3391     93 SVIDlatGKVVATIPVGG--GPRGLAVDPDGGRLYVADSgNGRVSVIDTATG------KVVATIPVGAGPHGIAVDPDGK 164

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907073704 1465 RILWIDARSDAIYS--ARYDGSGhMEVLRGHEFLSHPFAVTLY--GGEVYWTDWRTNTlakANkWTGHNVTVV 1533
Cdd:COG3391    165 RLYVANSGSNTVSVivSVIDTAT-GKVVATIPVGGGPVGVAVSpdGRRLYVANRGSNT---SN-GGSNTVSVI 232
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1949-2098 9.71e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 50.74  E-value: 9.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1949 AENDTIYWVDMGLSTISRAKRD-----QTWREDVVTNGIGRVEGIAVDwIAGNIYWTDQGFDVIEVARLNGSFRYVVISQ 2023
Cdd:cd14956     21 DADDNVYVADARNGRIQVFDKDgtflrRFGTTGDGPGQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLTGELQTIGGSS 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 2024 G-----LDKPRAITVHPeKGYLFWTEWGHYpRIERSRLDGT---------ERVvlvnVSISWPNGISVDyQGGKLYWCDA 2089
Cdd:cd14956    100 GsgpgqFNAPRGVAVDA-DGNLYVADFGNQ-RIQKFDPDGSflrqwggtgIEP----GSFNYPRGVAVD-PDGTLYVADT 172


                   ....*....
gi 1907073704 2090 RMDKIERID 2098
Cdd:cd14956    173 YNDRIQVFD 181
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2623-2654 9.87e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 9.87e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  2623 CGVGEFRCRDGSCIGNSSRCNQFVDCEDASDE 2654
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 293-455 9.96e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.39  E-value: 9.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  293 GNFYFVDDIDDRIFVCNRNGDTCVTLL-----DLELYNPKGIALDPAmGKVFFTDYGQIpKVERCDMDGQNRTKLV---- 363
Cdd:cd05819     19 GNIYVADTGNNRIQVFDPDGNFITSFGsfgsgDGQFNEPAGVAVDSD-GNLYVADTGNH-RIQKFDPDGNFLASFGgsgd 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  364 -DSKIVFPHGITLDLVSRlVYWADAYLDYIEVVDYEGKGRQTI-IQGILIEHL---YGLTVF-ENYLYATNSDNAntqqk 437
Cdd:cd05819     97 gDGEFNGPRGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLTTFgSGGSGPGQFngpTGVAVDsDGNIYVADTGNH----- 170

                          170
                   ....*....|....*...
gi 1907073704  438 tsviRVNRFNSTEYQVVT 455
Cdd:cd05819    171 ----RIQVFDPDGNFLTT 184
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2834-2867 1.01e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 2834 STCDDREFMCQNRLCIPKHFVCDHDRDCADGSDE 2867
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1890-2102 1.02e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 1.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1890 MCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAEND--TIYWVDMGLSTISRA 1967
Cdd:COG3391     16 LALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADgrRLYVANSGSGRVSVI 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1968 KRDQTWREDVVTNGiGRVEGIAVDWIAGNIYWTDQGFDviEVARLNGSFRYVV--ISQGlDKPRAITVHPEKGYLFWTEW 2045
Cdd:COG3391     96 DLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNG--RVSVIDTATGKVVatIPVG-AGPHGIAVDPDGKRLYVANS 171

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907073704 2046 GHyPRIER--SRLDGTERVVLVNVSI-SWPNGISVDYQGGKLYWCDAR-------MDKIERIDLETG 2102
Cdd:COG3391    172 GS-NTVSVivSVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGsntsnggSNTVSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1614-1840 1.47e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.69  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1614 VDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWV-----SR 1688
Cdd:COG3391      1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGAdagadGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1689 NLFWTSYDTNKKQInVARLDGSFKNAVVQGlEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNHTLL--FSGQKGPVGLA 1766
Cdd:COG3391     81 RLYVANSGSGRVSV-IDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVatIPVGAGPHGIA 158

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907073704 1767 IDFPESKLYWISSGNHTINR--CNLDGSELEVIDTMrSQLGKATALAIMGD--KLWWADQVSekmGTCNKADGSGSVV 1840
Cdd:COG3391    159 VDPDGKRLYVANSGSNTVSVivSVIDTATGKVVATI-PVGGGPVGVAVSPDgrRLYVANRGS---NTSNGGSNTVSVI 232
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3219-3259 1.52e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.84  E-value: 1.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 3219 ERIYWADAREDY-IEFASLDGSNRHVVLSQDIPHIFALTLFE 3259
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3431-3466 1.97e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 1.97e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 3431 CLPSQFKCtNTNRCIPGIFRCNGQDNCGDGEDERDC 3466
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 615-658 2.02e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 2.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907073704  615 DNLYWTDDGPKKTISVARLEkaAQTRKTLIEGKMTHPRAIVVDP 658
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLN--GSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2791-2824 2.08e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 2.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  2791 TCGPSSFSCPGTHvCVPERWLCDGDKDCTDGADE 2824
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 3108-3220 2.16e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.13  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3108 GSNVQ-VLHRTGLSNPDGLAVDwVGGNLYWCDKGRDTieVSKLNG--AYRTVLVSSGLREPRALVVDvQNGYLYWTDwGD 3184
Cdd:cd14952     81 GSTTQtVLPFTGLNDPTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVD-GAGNVYVTD-TG 155

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 3185 HSLIGRIGMDGSGRSIIVDTKITWPNGLTVD-----YVTER 3220
Cdd:cd14952    156 NNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDtagnvYVTDH 196
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2925-2957 2.37e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 2.37e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2925 SSQFLCSSGRCVAEALLCNGQDDCGDGSDERGC 2957
Cdd:pfam00057    5 PNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 663-709 2.39e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 2.39e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907073704  663 MYWTDWEEDPKdsrrgrLERAWMDGSHRDIFVTSKtVLWPNGLSLDI 709
Cdd:pfam00058    3 LYWTDSSLRAS------ISSADLNGSDRKTLFTDD-LQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2177-2212 2.45e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2177 CAVANGGCQQLCLYRGGGqRACACAHG-MLAEDGASC 2212
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGyELQDDGRTC 36
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 3108-3220 2.45e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.13  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3108 GSNVQ-VLHRTGLSNPDGLAVDwVGGNLYWCDKGRDtiEVSKLN-GAYR-TVLVSSGLREPRALVVDvQNGYLYWTDWGD 3184
Cdd:cd14952    123 GSNTQtVLPFTGLSNPDGVAVD-GAGNVYVTDTGNN--RVLKLAaGSTTqTVLPFTGLNSPSGVAVD-TAGNVYVTDHGN 198

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907073704 3185 HsligRI-GMD-GSGRSIIVD-TKITWPNGLTVD-----YVTER 3220
Cdd:cd14952    199 N----RVlKLAaGSTTPTVLPfTGLNGPLGVAVDaagnvYVADR 238
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 276-315 2.52e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.52e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907073704   276 ISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTC 315
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 3968-4132 2.63e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.13  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3968 THLNISGLKMPRGIAIDwVAGNVYWTDSGRD-VIEVAqmKGENRKTL--ISGMiDEPHAIVVDPlRGTMYWSDWGNHPKI 4044
Cdd:cd14952     44 TVLPFTGLYQPQGVAVD-AAGTVYVTDFGNNrVLKLA--AGSTTQTVlpFTGL-NDPTGVAVDA-AGNVYVADTGNNRVL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4045 ETAAMDGTlRETLVQDNIQWPTGLAVDyHNERLYWADAKLSVIGSIRLNGTDPIVAadSKRGLSHPFSIDV-FEDYIYGV 4123
Cdd:cd14952    119 KLAAGSNT-QTVLPFTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQTVL--PFTGLNSPSGVAVdTAGNVYVT 194


                   ....*....
gi 1907073704 4124 TYINNRVFK 4132
Cdd:cd14952    195 DHGNNRVLK 203
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1163-1196 2.68e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 1163 CRPPSHPCANNTsvCLPPDKLCDGKDDCGDGSDE 1196
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3764-3791 2.76e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.76e-05
                            10        20
                    ....*....|....*....|....*...
gi 1907073704  3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDE 3791
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 286-435 2.94e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 49.24  E-value: 2.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  286 MAIDwLTGNFYFVDDIDDRIFVCNRNGDTCVTLL-----DLELYNPKGIALDPAmGKVFFTDYG--QIpkvERCDMDGQN 358
Cdd:cd05819     60 VAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsgdgDGEFNGPRGIAVDSS-GNIYVADTGnhRI---QKFDPDGEF 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  359 RTKL-----VDSKIVFPHGITLDLvSRLVYWADAYLDYIEVVDYEGK-----GRQTIIQGILIeHLYGLTVFEN-YLYAT 427
Cdd:cd05819    135 LTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGNHRIQVFDPDGNflttfGSTGTGPGQFN-YPTGIAVDSDgNIYVA 212


                   ....*...
gi 1907073704  428 NSDNANTQ 435
Cdd:cd05819    213 DSGNNRVQ 220
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1163-1196 2.99e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.99e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  1163 CRPPSHPCANNTsvCLPPDKLCDGKDDCGDGSDE 1196
Cdd:smart00192    2 CPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1122-1155 3.78e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.78e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704  1122 CDPNvKFGCKDSaRCISKAWVCDGDSDCEDNSDE 1155
Cdd:smart00192    2 CPPG-EFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2792-2824 4.25e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.25e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2792 CGPSSFSCpGTHVCVPERWLCDGDKDCTDGADE 2824
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 552-594 5.31e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 5.31e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704   552 HMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTER 594
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1951-2109 6.09e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.09  E-value: 6.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1951 NDTIYWVDMGLSTISR-AKRDQTWREdVVTNGIGRVEGIAVDwIAGNIYWTDQGFDVIevARLN---GSFRYVVISQGLD 2026
Cdd:COG4257     27 DGAVWFTDQGGGRIGRlDPATGEFTE-YPLGGGSGPHGIAVD-PDGNLWFTDNGNNRI--GRIDpktGEITTFALPGGGS 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 2027 KPRAITVHPeKGYLFWTE-WGHypRIerSRLD-GTERVVLVNV--SISWPNGISVDyQGGKLYWCDARMDKIERIDLETG 2102
Cdd:COG4257    103 NPHGIAFDP-DGNLWFTDqGGN--RI--GRLDpATGEVTEFPLptGGAGPYGIAVD-PDGNLWVTDFGANAIGRIDPDTG 176


                   ....*..
gi 1907073704 2103 ENREVVL 2109
Cdd:COG4257    177 TLTEYAL 183
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 120-149 6.46e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 6.46e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073704  120 GCQHHCVPTPSGPTCYCNSSFQLQADGKTC 149
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2545-2575 6.81e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.58  E-value: 6.81e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 2545 QDEFECANGECISFSLTCDGVSHCKDKSDEK 2575
Cdd:cd00112      3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3119-3220 7.08e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.08  E-value: 7.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3119 LSNPDGLAVDwVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSG-----LREPRALVVDvQNGYLYWTDWGDHSlIGRIGM 3193
Cdd:cd05819     54 FNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVD-SSGNIYVADTGNHR-IQKFDP 130

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907073704 3194 DGSGRSII-----VDTKITWPNGLTVD-----YVTER 3220
Cdd:cd05819    131 DGEFLTTFgsggsGPGQFNGPTGVAVDsdgniYVADT 167
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 72-105 7.37e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 7.37e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907073704    72 RCPPNEHSCLGTElCVPMSRLCNGIQDCMDGSDE 105
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2790-2824 7.62e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 7.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907073704 2790 KTCGPSSFSCpGTHVCVPERWLCDGDKDCTDGADE 2824
Cdd:pfam00057    1 STCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
72-109 8.16e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 8.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907073704   72 RCPPNEHSCLGTElCVPMSRLCNGIQDCMDGSDEgAHC 109
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDE-ENC 37
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 3113-3220 8.73e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.59  E-value: 8.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3113 VLHRTGLSNPDGLAVDwVGGNLYWCDKGRDtiEVSKLN-GAYR-TVLVSSGLREPRALVVDVqNGYLYWTDWGDHSLIGR 3190
Cdd:cd14952      3 VLPFTGLDGPGGVAVD-AAGNVYVADSGNN--RVLKLAaGSTTqTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKL 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907073704 3191 IGmdGSGRSIIV-DTKITWPNGLTVD-----YVTER 3220
Cdd:cd14952     79 AA--GSTTQTVLpFTGLNDPTGVAVDaagnvYVADT 112
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1631-1667 1.16e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 1.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907073704  1631 DIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGV 1667
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3975-4082 1.17e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 47.20  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3975 LKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTLISG-MIDEPHAIVVDPLRGTMYWSDWGNHpKIETAAMDGTL 4053
Cdd:cd14962     56 FVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGaLFKRPTGIAVDPAGKRLYVVDTLAH-KVKVFDLDGRL 133

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907073704 4054 RETLVQD-------NIqwPTGLAVDyHNERLYWADA 4082
Cdd:cd14962    134 LFDIGKRgsgpgefNL--PTDLAVD-RDGNLYVTDT 166
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3076-3232 1.19e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 47.28  E-value: 1.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3076 NAVALDFDYReqmIYWTDVTT--------QGSMIRRMHLNGSNVQvlhrtGLSNPDGLAVDwVGGNLYWCDKGRDTIEVS 3147
Cdd:cd14956     16 RGIAVDADDN---VYVADARNgriqvfdkDGTFLRRFGTTGDGPG-----QFGRPRGLAVD-KDGWLYVADYWGDRIQVF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3148 KLNGAYRTVLVSSG-----LREPRALVVDVqNGYLYWTDWGDHSlIGRIGMDGS-----GRSIIVDTKITWPNGLTVDYV 3217
Cdd:cd14956     87 TLTGELQTIGGSSGsgpgqFNAPRGVAVDA-DGNLYVADFGNQR-IQKFDPDGSflrqwGGTGIEPGSFNYPRGVAVDPD 164

                          170
                   ....*....|....*
gi 1907073704 3218 tERIYWADAREDYIE 3232
Cdd:cd14956    165 -GTLYVADTYNDRIQ 178
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 73-105 1.23e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.23e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704   73 CPPNEHSClGTELCVPMSRLCNGIQDCMDGSDE 105
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
DUF5050 pfam16472
Domain of unknown function (DUF5050);
3053-3271 1.23e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 47.24  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3053 NRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYreqmIYWTDV-TTQGSMIRRMHLNGSNvqvlhRTGLSNPDGLAVDWVG 3131
Cdd:pfam16472   77 SLTGLYRIKLDGTNRTKLDDDPSLYVSLYGNY----IYYQHYdNSDGGTLYKIKIDGKE-----KTKLSDEPISPASVSD 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3132 GNLYWCDKGRD-TIEVSKLNGAYRTVLVSSGLREPralvvDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPN 3210
Cdd:pfam16472  148 GWIYYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP-----NVNGDYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN 222

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907073704 3211 gLTVDYvterIYWADARED-YIEFASLDGSNRHVVLSQDIPHIfalTLFEDYVYWTDWETKS 3271
Cdd:pfam16472  223 -VYGNW----IYYQNNGDDnKLYRINTDGSNKEKLAEGNYTNI---NITSDYIYFTDFGSDS 276
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1645-1685 1.30e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 1.30e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1645 QRVYWSDVRTQA-IKRAFINGTGVETVVSADLPNAHGLAVDW 1685
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3242-3282 1.31e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.20  E-value: 1.31e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907073704  3242 HVVLSQDIPHI--FALTLFEDYVYWTDWETKSINRAhKTTGAN 3282
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVA-NLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3713-3749 1.44e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 3713 CPPNRpFRCKNDRvCLWIGRQCDGVDNCGDGTDEEDC 3749
Cdd:cd00112      1 CPPNE-FRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
303-443 1.44e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.61  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  303 DRIFVCNRNGDTcVTLLDLE----------LYNPKGIALDPAMGKVFFTDY--GQIPKVercdmDGQNRTklVDSKI--- 367
Cdd:COG3391     80 RRLYVANSGSGR-VSVIDLAtgkvvatipvGGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGK--VVATIpvg 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  368 VFPHGITLDLVSRLVYWADAYLD----YIEVVDYE-GKGRQTIIQGiliEHLYGLTV--FENYLYATNSDNANTQQKTSV 440
Cdd:COG3391    152 AGPHGIAVDPDGKRLYVANSGSNtvsvIVSVIDTAtGKVVATIPVG---GGPVGVAVspDGRRLYVANRGSNTSNGGSNT 228


                   ...
gi 1907073704  441 IRV 443
Cdd:COG3391    229 VSV 231
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3119-3218 1.50e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.93  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3119 LSNPDGLAVDwVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSG-----LREPRALVVDvQNGYLYWTDWGDHSlIGRIGM 3193
Cdd:cd05819      7 LNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHR-IQKFDP 83

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907073704 3194 DGS-----GRSIIVDTKITWPNGLTVD-----YVT 3218
Cdd:cd05819     84 DGNflasfGGSGDGDGEFNGPRGIAVDssgniYVA 118
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1419-1461 1.65e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 1.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907073704 1419 LFWTDWdaSL-PRIEAASMSGAGRRTIHreTGSGGWPNGLTVDY 1461
Cdd:pfam00058    3 LYWTDS--SLrASISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 3966-4131 1.71e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 46.88  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3966 GVTHLNISGLKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTLIS-----GMIDEPHAIVVDPlRGTMYWSDWGN 4040
Cdd:cd14957    102 GTGGSGDGQFNGPYGIAVD-SNGNIYVADTGNHRIQVFTSSGTFSYSIGSggtgpGQFNGPQGIAVDS-DGNIYVADTGN 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4041 HpKIETAAMDGTLRETLVQDNIQ-----WPTGLAVD---------YHNERLYWADAKLSVIGSIRLNGTDPivaadskRG 4106
Cdd:cd14957    180 H-RIQVFTSSGTFQYTFGSSGSGpgqfsDPYGIAVDsdgniyvadTGNHRIQVFTSSGAYQYSIGTSGSGN-------GQ 251

                          170       180
                   ....*....|....*....|....*.
gi 1907073704 4107 LSHPFSIDVF-EDYIYGVTYINNRVF 4131
Cdd:cd14957    252 FNYPYGIAVDnDGKIYVADSNNNRIQ 277
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1933-2108 1.78e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.81  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1933 LVPVSGTSLAVGIDFHAENdTIYWVDMGLSTISRAKRDqTWREDVVTNGIGRVEGIAVDWiAGNIYWTDQGFDVIEVARL 2012
Cdd:COG3386      1 KLADAGFRLGEGPVWDPDG-RLYWVDIPGGRIHRYDPD-GGAVEVFAEPSGRPNGLAFDP-DGRLLVADHGRGLVRFDPA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 2013 NGSFRyvVISQGLDKPRA----ITVHPeKGYLFWTEWGHYPRIER-SRLDGTERVVLVNVSISWPNGISVDYQGGKLYWC 2087
Cdd:COG3386     78 DGEVT--VLADEYGKPLNrpndGVVDP-DGRLYFTDMGEYLPTGAlYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVA 154

                          170       180
                   ....*....|....*....|....
gi 1907073704 2088 DARMDKIERIDL-ETGE--NREVV 2108
Cdd:COG3386    155 DTGAGRIYRFDLdADGTlgNRRVF 178
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 3978-4133 1.88e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 47.14  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3978 PRGIAIDwVAGNVYWTDSGRDVIevaqmkgenRKTLISGMI----------------------DEPHAIVVDPlRGTMYW 4035
Cdd:cd14953     79 PSGVAVD-AAGNLYVADTGNHRI---------RKITPDGVVstlagtgtagfsddggataaqfNYPTGVAVDA-AGNLYV 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4036 SDWGNHP--KIETA--------------AMDGTLRETLVQdniqWPTGLAVDYHNeRLYWADA------KLSVIGSIR-L 4092
Cdd:cd14953    148 ADTGNHRirKITPDgvvttvagtggagyAGDGPATAAQFN----NPTGVAVDAAG-NLYVADRgnhrirKITPDGVVTtV 222

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1907073704 4093 NGTDPIVAAD----SKRGLSHPFSIDVFEDyiyGVTYI----NNRVFKI 4133
Cdd:cd14953    223 AGTGTAGFSGdggaTAAQLNNPTGVAVDAA---GNLYVadsgNHRIRKI 268
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2545-2574 1.89e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.89e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907073704  2545 QDEFECANGECISFSLTCDGVSHCKDKSDE 2574
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 141-188 3.27e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 3.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1907073704  141 QLQadGKTCKDFDECSVYG-TCSQLCTNTDGSFTCGCVEGYLLQPDNRS 188
Cdd:cd01475    178 KFQ--GKICVVPDLCATLShVCQQVCISTPGSYLCACTEGYALLEDNKT 224
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3764-3794 3.29e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.29e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907073704 3764 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3794
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 3970-4071 3.36e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.66  E-value: 3.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3970 LNISGLKMPRGIAIDwVAGNVYWTDSGRD-VIEVAQmkGENRKTLI--SGMiDEPHAIVVDPlRGTMYWSDWGNHPKIET 4046
Cdd:cd14952      4 LPFTGLDGPGGVAVD-AAGNVYVADSGNNrVLKLAA--GSTTQTVLpfTGL-YQPQGVAVDA-AGTVYVTDFGNNRVLKL 78

                           90       100
                   ....*....|....*....|....*
gi 1907073704 4047 AAmDGTLRETLVQDNIQWPTGLAVD 4071
Cdd:cd14952     79 AA-GSTTQTVLPFTGLNDPTGVAVD 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2582-2618 3.56e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 2582 RRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPC 2618
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1868-1904 3.79e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.79e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907073704 1868 CSVNNGDCSQLCLPTSEtTRSCMCTAGYSLRSGQQAC 1904
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3350-3383 3.81e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704 3350 SNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3383
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3975-4041 4.18e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.74  E-value: 4.18e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907073704 3975 LKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTLIS-----GMIDEPHAIVVDPlRGTMYWSDWGNH 4041
Cdd:cd14956    200 FNYPYGIAID-PDGNVFVADFGNNRIQKFTADGTFLTSWGSpgtgpGQFKNPWGVVVDA-DGTVYVADSNNN 269
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3975-4081 4.38e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 45.36  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3975 LKMPRGIAIDwVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDE-----PHAIVVDPlRGTMYWSDWGNHpKIETAAM 4049
Cdd:cd14963    147 LSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVDP-DGNLYVVDNLSH-RVYVFDE 223

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907073704 4050 DGTLRETLVQ---DNIQW--PTGLAVDyHNERLYWAD 4081
Cdd:cd14963    224 QGKELFTFGGrgkDDGQFnlPNGLFID-DDGRLYVTD 259
EGF_CA smart00179
Calcium-binding EGF-like domain;
3000-3029 4.77e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 4.77e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704  3000 DLDECSTTFPCSQ--LCINTHGSYKCLCVEGY 3029
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 3968-4071 4.83e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.28  E-value: 4.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3968 THLNISGLKMPRGIAIDwVAGNVYWTDSGRD-VIEVAQmkGENRKTLIS-GMIDEPHAIVVDPlRGTMYWSDWGNHPKIE 4045
Cdd:cd14952    128 TVLPFTGLSNPDGVAVD-GAGNVYVTDTGNNrVLKLAA--GSTTQTVLPfTGLNSPSGVAVDT-AGNVYVTDHGNNRVLK 203

                           90       100
                   ....*....|....*....|....*.
gi 1907073704 4046 TAAMDGTLrETLVQDNIQWPTGLAVD 4071
Cdd:cd14952    204 LAAGSTTP-TVLPFTGLNGPLGVAVD 228
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1328-1485 4.91e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 4.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1328 ALYWTDVVEDKIYRgKLLDNGALTSFE-----------------VVIQYG---------------LATPEG--------L 1367
Cdd:COG3386     20 RLYWVDIPGGRIHR-YDPDGGAVEVFAepsgrpnglafdpdgrlLVADHGrglvrfdpadgevtvLADEYGkplnrpndG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1368 AVDWiAGNIYWVESNLDQIE--VAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASlpRIEAASMSGAG----R 1441
Cdd:COG3386     99 VVDP-DGRLYFTDMGEYLPTgaLYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAG--RIYRFDLDADGtlgnR 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1907073704 1442 RTIHRETGSGGWPNGLTVDylekrilwidaRSDAIYSARYDGSG 1485
Cdd:COG3386    176 RVFADLPDGPGGPDGLAVD-----------ADGNLWVALWGGGG 208
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3132-3171 5.12e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 5.12e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 3132 GNLYWCDKG-RDTIEVSKLNGAYRTVLVSSGLREPRALVVD 3171
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
614-774 5.28e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 5.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  614 GDNLYWTDDGPKkTISVARLEKAAQTRkTLIEGKmtHPRAIVVDPLNGWMYWTDWEE------DPKDsrrGRLERAWMDG 687
Cdd:COG3391     79 GRRLYVANSGSG-RVSVIDLATGKVVA-TIPVGG--GPRGLAVDPDGGRLYVADSGNgrvsviDTAT---GKVVATIPVG 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  688 ShrdifvtsktvlWPNGLSLDIPAGRLYWVDAFYDRIETIL--LNGTDRKIVYEGPELNHAFGLC--HHGNYLFWTEYRS 763
Cdd:COG3391    152 A------------GPHGIAVDPDGKRLYVANSGSNTVSVIVsvIDTATGKVVATIPVGGGPVGVAvsPDGRRLYVANRGS 219

                          170
                   ....*....|.
gi 1907073704  764 GSVYRLERGVA 774
Cdd:COG3391    220 NTSNGGSNTVS 230
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3000-3029 6.75e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 6.75e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907073704 3000 DLDECSTTFPCS--QLCINTHGSYKCLCVEGY 3029
Cdd:cd00054      1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY 32
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1939-2102 8.37e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1939 TSLAVgidfhAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVE-----GIAVDwIAGNIYWTDQGFDVIEVARLN 2013
Cdd:cd05819     11 QGIAV-----DSSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVD-SDGNLYVADTGNHRIQKFDPD 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 2014 GSFRYVVISQGLDK-----PRAITVHPEkGYLFWTEWGHYpRIERSRLDGTERVVLVNVSISW-----PNGISVDyQGGK 2083
Cdd:cd05819     85 GNFLASFGGSGDGDgefngPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGN 161

                          170
                   ....*....|....*....
gi 1907073704 2084 LYWCDARMDKIERIDLETG 2102
Cdd:cd05819    162 IYVADTGNHRIQVFDPDGN 180
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3089-3129 8.70e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 8.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 3089 IYWTDVTTQGSmIRRMHLNGSNVQVLHRTGLSNPDGLAVDW 3129
Cdd:pfam00058    3 LYWTDSSLRAS-ISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1294-1478 9.52e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.50  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1294 RHEIRRIDLHKGDYSVLVPGLRNT------IALDfhlSQSALYWTDVVEDKIYRgklLDNGALtsFEVVIQYGLAT--PE 1365
Cdd:cd14962     32 RGAVFVFDLPNGKVFVIGNAGPNRfvspigVAID---ANGNLYVSDAELGKVFV---FDRDGK--FLRAIGAGALFkrPT 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1366 GLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTL-----LAGDIEHPRAIALDpRDGILFWTdwDASLPRIEAASMSGAG 1440
Cdd:cd14962    104 GIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIgkrgsGPGEFNLPTDLAVD-RDGNLYVT--DTMNFRVQIFDADGKF 180

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1907073704 1441 RRTI-HRETGSGGW--PNGLTVDYlEKRILWIDARSDA--IYS 1478
Cdd:cd14962    181 LRSFgERGDGPGSFarPKGIAVDS-EGNIYVVDAAFDNvqIFN 222
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2540-2575 1.07e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.15  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907073704 2540 SSCRAqDEFECANGECISFSLTCDGVSHCKDKSDEK 2575
Cdd:pfam00057    1 STCSP-NEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1664-1782 1.16e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.12  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1664 GTGVETVVS-ADLPNAHGLAVDwVSRNLFWTSYDTNkkqiNVARLDGSFKNAVV---QGLEQPHGLVVHPlRGKLYWTDG 1739
Cdd:cd14952     81 GSTTQTVLPfTGLNDPTGVAVD-AAGNVYVADTGNN----RVLKLAAGSNTQTVlpfTGLSNPDGVAVDG-AGNVYVTDT 154

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1907073704 1740 DNISMANMDGSNHT---LLFSGQKGPVGLAIDfPESKLYWISSGNH 1782
Cdd:cd14952    155 GNNRVLKLAAGSTTqtvLPFTGLNSPSGVAVD-TAGNVYVTDHGNN 199
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3131-3274 1.28e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3131 GGNLYWCDKGRDTIEV-SKLNGAY-RTVLVSSGlrePRALVVDVQNGYLYWTDWGDHSLIGrigMDGSGRSIIvdTKIT- 3207
Cdd:COG3391     79 GRRLYVANSGSGRVSViDLATGKVvATIPVGGG---PRGLAVDPDGGRLYVADSGNGRVSV---IDTATGKVV--ATIPv 150

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907073704 3208 --WPNGLTVDYVTERIYWADAREDYIE--FASLDGSNRHVVLSQDI---PHIFALTLFEDYVYWTDWETKSINR 3274
Cdd:COG3391    151 gaGPHGIAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVgggPVGVAVSPDGRRLYVANRGSNTSNG 224
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2684-2706 1.48e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.73  E-value: 1.48e-03
                           10        20
                   ....*....|....*....|...
gi 1907073704 2684 CYAPSWVCDGANDCGDYSDERDC 2706
Cdd:cd00112     13 CIPSSWVCDGEDDCGDGSDEENC 35
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 3976-4132 1.54e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 43.72  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3976 KMPRGIAIDwVAGNVYWTDSGRDVIEvaqmKGENRKTLIS---------GMIDEPHAIVVDPlRGTMYWSDWGNHpKIET 4046
Cdd:cd14955    110 NSPSGIAVD-SAGNVYVTDSGNNRIQ----KFDSSGTFITkwgsfgsgdGQFNSPTGIAVDS-AGNVYVADTGNN-RIQK 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4047 AAMDGTL---RETLVQDNIQ--WPTGLAVDyHNERLYWADAKLSVIGSIRLNGTdpivaADSKRG--------LSHPFSI 4113
Cdd:cd14955    183 FTSTGTFltkWGSEGSGDGQfnAPYGIAVD-SAGNVYVADTGNNRIQKFDSSGT-----FITKWGsegsgdgqFNSPSGI 256

                          170       180
                   ....*....|....*....|
gi 1907073704 4114 DV-FEDYIYGVTYINNRVFK 4132
Cdd:cd14955    257 AVdSAGNVYVADSGNNRIQK 276
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2500-2532 1.64e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907073704 2500 CRINNGGCQDLCLLTHQGHVnCSCRGGRILQED 2532
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDD 32
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 608-775 1.74e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 43.73  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  608 VAVDWMGdNLYWTD-DGPKKTISVARLEKAAQTRkTLIEGkMTHPRAIVVDPLNGWMYWTdweedpkDSRRGRLERAWMD 686
Cdd:COG3386     98 GVVDPDG-RLYFTDmGEYLPTGALYRVDPDGSLR-VLADG-LTFPNGIAFSPDGRTLYVA-------DTGAGRIYRFDLD 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704  687 G----SHRDIFVT-SKTVLWPNGLSLDiPAGRLYWVDAFYDRIETILLNGT-DRKIvyEGPEL---NHAFGLcHHGNYLF 757
Cdd:COG3386    168 AdgtlGNRRVFADlPDGPGGPDGLAVD-ADGNLWVALWGGGGVVRFDPDGElLGRI--ELPERrptNVAFGG-PDLRTLY 243

                          170       180
                   ....*....|....*....|..
gi 1907073704  758 WTEYRS----GSVYRLERGVAG 775
Cdd:COG3386    244 VTTARSlplaGALFRVRVDVPG 265
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2969-2998 1.99e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 1.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907073704 2969 GCSQDCEDLKIGFKCRCRPGFRLKDDGRTC 2998
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2341-2386 2.79e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.79e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1907073704  2341 ETVITmSGDDHPRAFVLDECQNLMFWTNWNelHPSIMRAALSGANV 2386
Cdd:smart00135    1 RTLLS-SGLGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2407-2446 3.04e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 3.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704 2407 EKLYFSDATLD-KIERCEYDGSHRYVILKSEPVHPFGLAVY 2446
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1364-1460 3.60e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 42.65  E-value: 3.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1364 PEGLAVDwIAGNIYWVESNLDQIEVAKLDGTLRTTL-----LAGDIEHPRAIALDPRDGIL---FWTDwdaslpRIEAAS 1435
Cdd:cd14956     15 PRGIAVD-ADDNVYVADARNGRIQVFDKDGTFLRRFgttgdGPGQFGRPRGLAVDKDGWLYvadYWGD------RIQVFT 87

                           90       100
                   ....*....|....*....|....*...
gi 1907073704 1436 MSGAGRRTIHRE---TGSGGWPNGLTVD 1460
Cdd:cd14956     88 LTGELQTIGGSSgsgPGQFNAPRGVAVD 115
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 487-520 4.21e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907073704  487 PGGCSDICLlaNSHKARTCRCRSGFSLGSDGKSC 520
Cdd:pfam14670    5 NGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1732-1768 4.46e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 4.46e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907073704 1732 GKLYWTDGDN---ISMANMDGSNHTLLFS--GQKgPVGLAID 1768
Cdd:pfam00058    1 GRLYWTDSSLrasISSADLNGSDRKTLFTddLQH-PNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2680-2706 5.12e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 5.12e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907073704 2680 RTSLCYAPSWVCDGANDCGDYSDERDC 2706
Cdd:pfam00057   11 GSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1934-1974 5.35e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 5.35e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  1934 VPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR 1974
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 336-376 6.48e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 6.48e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907073704  336 GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLD 376
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1329-1460 7.06e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 1329 LYWTDVVEDKIY----RGKLLDN-GALTSFEVVIQYglatPEGLAVDwIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGD 1403
Cdd:cd14963    114 LYVSDVKKHKVIvfdlEGKLLLEfGKPGSEPGELSY----PNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSP 188

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907073704 1404 I-----EHPRAIALDPrDGILFWTDWDASlpRIEAASMSGAGRRTIHR---ETGSGGWPNGLTVD 1460
Cdd:cd14963    189 DgksgfVNPRGIAVDP-DGNLYVVDNLSH--RVYVFDEQGKELFTFGGrgkDDGQFNLPNGLFID 250
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 2982-3003 7.24e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 7.24e-03
                           10        20
                   ....*....|....*....|..
gi 1907073704 2982 KCRCRPGFRLKDDGRTCADLDE 3003
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3974-4130 7.64e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.51  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3974 GLKMPRGIAIDWvaGNVYWTDSGRDVIEVAQMKGENRKTL-----ISGMIDEPHAIVVDPlRGTMYWSDWGNHpKIETAA 4048
Cdd:cd14963      8 PLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFggpgtGPGEFKYPYGIAVDS-DGNIYVADLYNG-RIQVFD 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 4049 MDGTLRETLVQD----NIQWPTGLAVDyhNERLYWADAKLSVIGSIRLNGTD--PIVAADSKRG-LSHPFSIDVFED-YI 4120
Cdd:cd14963     84 PDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLllEFGKPGSEPGeLSYPNGIAVDEDgNI 161

                          170
                   ....*....|
gi 1907073704 4121 YGVTYINNRV 4130
Cdd:cd14963    162 YVADSGNGRI 171
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2293-2333 7.77e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.77e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907073704  2293 RTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQT 2333
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 3916-4133 7.85e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.42  E-value: 7.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3916 ESVRIDAmdvhvkAGRVYWTNWHTGTIsyrslppaappttsnrHRRQIDRGVTHLNISGLKMPRGIAIDWvAGNVYWTDS 3995
Cdd:COG3386     11 EGPVWDP------DGRLYWVDIPGGRI----------------HRYDPDGGAVEVFAEPSGRPNGLAFDP-DGRLLVADH 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073704 3996 GRDVIEVAQMKGEnRKTLISGmIDEPHA----IVVDPlRGTMYWSDWGNHPKieTAAM-----DGTLRetLVQDNIQWPT 4066
Cdd:COG3386     68 GRGLVRFDPADGE-VTVLADE-YGKPLNrpndGVVDP-DGRLYFTDMGEYLP--TGALyrvdpDGSLR--VLADGLTFPN 140

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907073704 4067 GLAVDYHNERLYWADAKLSVIGSIRLNGTDPI----VAADSKRGLSHP--FSIDVfEDYIYGVTYINNRVFKI 4133
Cdd:COG3386    141 GIAFSPDGRTLYVADTGAGRIYRFDLDADGTLgnrrVFADLPDGPGGPdgLAVDA-DGNLWVALWGGGGVVRF 212
EGF_CA smart00179
Calcium-binding EGF-like domain;
151-180 9.97e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 9.97e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907073704   151 DFDECSVYGTCSQ--LCTNTDGSFTCGCVEGY 180
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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