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Conserved domains on  [gi|1907183529|ref|XP_036009263|]
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tetratricopeptide repeat protein 23 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
82-321 2.65e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529  82 EYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkcslel 161
Cdd:COG0457    23 RYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA--------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 162 FYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYteit 241
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYERALEL---- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 242 kdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIILSKDPSPEEA 321
Cdd:COG0457   140 ----DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILT 215
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
82-321 2.65e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529  82 EYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkcslel 161
Cdd:COG0457    23 RYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA--------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 162 FYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYteit 241
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYERALEL---- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 242 kdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIILSKDPSPEEA 321
Cdd:COG0457   140 ----DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILT 215
TPR_12 pfam13424
Tetratricopeptide repeat;
209-275 3.06e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907183529 209 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 275
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
82-321 2.65e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529  82 EYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkcslel 161
Cdd:COG0457    23 RYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA--------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 162 FYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYteit 241
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYERALEL---- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 242 kdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIILSKDPSPEEA 321
Cdd:COG0457   140 ----DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILT 215
TPR_12 pfam13424
Tetratricopeptide repeat;
209-275 3.06e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907183529 209 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 275
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 82-279 3.11e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529  82 EYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKglslqakqHAEKAKEILANSIESPCHNktdifkcsLEL 161
Cdd:COG2956    57 EYDRAIRIHQKLLERDP--------DRAEALLELAQDYLKAG--------LLDRAEELLEKLLELDPDD--------AEA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 162 FYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEit 241
Cdd:COG2956   113 LRLLAEIYEQEGDWEKAIEVLERLLKLGPE---------------NAHAYCELAELYLEQGDYDEAIEALEKALKLDP-- 175

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907183529 242 kdekslECVQVLRELAGVEQALGLYAAAISHFSRKPRQ 279
Cdd:COG2956   176 ------DCARALLLLAELYLEQGDYEEAIAALERALEQ 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
107-275 6.95e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 6.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 107 KLAEAYVNLAQGYLQLkGLSLQAKQHAEKAKEILANSIESpchnktdifkcslelFYTLGRALLSLQKFKDASENLIKAE 186
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDAEA---------------LYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 187 RLSKEMLQCgnivkeeWIEIqsriklsfAQLYQGQKRSKEAFPFYQKALEYteitkdekSLECVQVLRELAGVEQALGLY 266
Cdd:COG0457    70 ELDPDDAEA-------LNNL--------GLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126


                  ....*....
gi 1907183529 267 AAAISHFSR 275
Cdd:COG0457   127 DEAIEAYER 135
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 158-303 7.68e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.60  E-value: 7.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 158 SLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEy 237
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA- 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907183529 238 teitKDEKSlecVQVLRELAGVEQALGLYAAAISHFSRkprqvcagLHSLLPTASGWKLWTAHITR 303
Cdd:COG4235    80 ----LDPDN---PEALYLLGLAAFQQGDYAEAIAAWQK--------LLALLPADAPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 162-438 1.05e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 162 FYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQKALEyteit 241
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVE---------------AHLALGNLYRRRGEYDRAIRIHQKLLE----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 242 KDEKSLecvQVLRELAGVEQALGLYAAAISHFSRkprqvcagLHSLLPTASGWKLWTAHI---TRMTQAHLIILSKdpSP 318
Cdd:COG2956    71 RDPDRA---EALLELAQDYLKAGLLDRAEELLEK--------LLELDPDDAEALRLLAEIyeqEGDWEKAIEVLER--LL 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 319 EEAADSAHFIARAAAASGMHDHRDVAEKYFQEsmtSIKDSEGAERAKFLSIQdefcsFLQTTGQKERAAMILRESLEAkv 398
Cdd:COG2956   138 KLGPENAHAYCELAELYLEQGDYDEAIEALEK---ALKLDPDCARALLLLAE-----LYLEQGDYEEAIAALERALEQ-- 207

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907183529 399 gafgdfSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 438
Cdd:COG2956   208 ------DPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 80-270 1.77e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529  80 SHEYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkcsl 159
Cdd:COG2956   123 EGDWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYD-EAIEALEKALKLDPDCARA------------- 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 160 elFYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQKALEytE 239
Cdd:COG2956   181 --LLLLAELYLEQGDYEEAIAALERALEQDPDYLP---------------ALPRLAELYEKLGDPEEALELLRKALE--L 241

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907183529 240 ITKDEKSLECVQVLRELAGVEQALGLYAAAI 270
Cdd:COG2956   242 DPSDDLLLALADLLERKEGLEAALALLERQL 272
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 109-236 2.93e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.36  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 109 AEAYVNLAQGYLQLkGLSLQAKQHAEKAKEIlansieSPCHnktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERL 188
Cdd:COG3914   112 AEALFNLGNLLLAL-GRLEEALAALRRALAL------NPDF---------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907183529 189 SKEMlqcgnivkeewIEIQSRIklsfAQLYQGQKRSKEAFPFYQKALE 236
Cdd:COG3914   176 DPDN-----------AEALNNL----GNALQDLGRLEEAIAAYRRALE 208
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 119-275 7.91e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.71  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907183529 119 YLQLKGLSLQAKQHAEKAKEILANSIEspchnktdIFKCSLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgni 198
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALLEKALE--------LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907183529 199 vkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSR 275
Cdd:COG4783    71 --------EPEARLNLGLALLKAGDYDEALALLEKALKLDP--------EHPEAYLRLARAYRALGRPDEAIAALEK 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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