|
Name |
Accession |
Description |
Interval |
E-value |
| Sec63 |
pfam02889 |
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of ... |
345-658 |
4.50e-69 |
|
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Pssm-ID: 460740 Cd Length: 307 Bit Score: 233.25 E-value: 4.50e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 345 PTEAGRLMAWYYITFETVKKFC-AISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKdpnriTIRFPMAERIKTR 423
Cdd:pfam02889 1 PTDLGRIASHYYISYETIETFNqSLKPNTTLADLLRILSSASEFEQIPVRQEEKKELKKLLE-----KVPIPVKGDIEDP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 424 EMKVNCLIQAQLGCIPIQDFALTQDTVKIFRNGSRIARWLSDfVAAQEKKFAVLLNSVILTKCFKCKLWeNSKHVSKQLD 503
Cdd:pfam02889 76 HAKVNILLQAYISRLKLPGFALVSDMNYILQNAGRILRALFE-ILLSKGWLSAALTALDLCKMIEQRMW-DSDSPLRQFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 504 KIGISLSNTMVNAGLTSFKKIEEANARELELILNRHPPFGTQIKEAVAHLPKYELEVEqIARYSDIKAEILVTIIlRNFE 583
Cdd:pfam02889 154 GIPPELIKKLEKKGVESVRDILELDDAEELGELIRNPKMGKDIAQFVNRFPKIEIEAE-VQPITRSVLRVEVTIT-PDFP 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720413921 584 qlQTKRTAPDFHYATLIIGDADNQVVFKHKIMdSVLLKSGNWVKKIDVKRALISE---DLSINLISSDYVGLDIHQKF 658
Cdd:pfam02889 232 --WDKRVHGKSEGFWLVVGDSDGNEILHIERF-TLTKRTLAGEHKLEFTVPPSDPgppQLFVRLISDSWLGADQEVPI 306
|
|
| Sec63 |
smart00973 |
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl ... |
345-660 |
8.33e-61 |
|
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Pssm-ID: 214946 Cd Length: 314 Bit Score: 210.29 E-value: 8.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 345 PTEAGRLMAWYYITFETVKKFCA-ISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKDpnritIRFPMAERIKTR 423
Cdd:smart00973 1 PTELGRIASYYYISYETIETFNQsLKPTTTLKDILEILSRASEFKEIPVRHNEKKELNELNKR-----VPIPVKEGIIDS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 424 EM-KVNCLIQAQLGCIPIQDFALTQDTVKIFRNGSRIARWLSDfVAAQEKKFAVLLNSVILTKCFKCKLWENSKHVSKQL 502
Cdd:smart00973 76 PHaKVNLLLQAHLSRLPLPDFDLVSDLKYILQNAPRILRALVD-IALSKGWLRTALNALDLSQMVVQRLWEDSDSPLKQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 503 DKIGIS--LSNTMVNAGLTSFKKIEEANARELELILNRHPPFGTQIKEAVAHLPKYELEVEQIARYSDIKAEILVTIIlr 580
Cdd:smart00973 155 PHFLIEdvYDKLELKDGSRSFELLLDMNAAELGEFLNRLPPNGRLIYELLRRFPKIEVEAEVLPITRDLTLRVELEIT-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 581 NFEQLQTKRTAPDFHYATLIIGDADNQVVFKHKIMDSVLLKSGNWVK-KIDVKR-ALISEDLSINLISSDYVGLDIHQKF 658
Cdd:smart00973 233 PVFAWDLPRHKGKSESWWLVVGDSDTNELLAIKRVTLRKKKKSNEVKlDFTVPLsEPGPENYTVYLISDSYLGCDQEVSF 312
|
..
gi 1720413921 659 TV 660
Cdd:smart00973 313 SL 314
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
55-239 |
2.27e-60 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 203.17 E-value: 2.27e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 55 RPVKLQKVVLGFPCSSSQTEFKFDL--ALNYKVYSVIRTYSDQKPTLVFCSTRKGVQQAASVLVkdakfiisveqklrlq 132
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNkfDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLA---------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 133 ksaysirdsklkdtlvyGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYS 212
Cdd:cd18795 65 -----------------GIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELS 127
|
170 180
....*....|....*....|....*..
gi 1720413921 213 ETDILQMIGRAGRPQFDTTATAVIMTR 239
Cdd:cd18795 128 PLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
18-389 |
2.51e-55 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 201.28 E-value: 2.51e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 18 PVRFVAVSATIPNAEDIAEWLsdgERPAVclkmDESHRPVKLQKVV-----LGFPCSSSQTEFKFdLALnykvysVIRTY 92
Cdd:COG1204 171 EAQIVALSATIGNAEEIAEWL---DAELV----KSDWRPVPLNEGVlydgvLRFDDGSRRSKDPT-LAL------ALDLL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 93 SDQKPTLVFCSTRKGVQQAASVLVKDAKFIISVEQKLRLQKSAYSIR--------DSKLKDTLVYGVGYHHAGMELSDRK 164
Cdd:COG1204 237 EEGGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREELEELAEELLevseethtNEKLADCLEKGVAFHHAGLPSELRR 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 165 LVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTmHYSGGVfeEYSETDILQMIGRAGRPQFDTTATAVIMTRLST-- 242
Cdd:COG1204 317 LVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDT-KRGGMV--PIPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDea 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 243 ---REKYVqmLACNDTVESSLH--RHLIEHLNAEIVLHTITDVNIALDWIRSTMLYIRAlknpshygfssglNKDGIEAK 317
Cdd:COG1204 394 delFERYI--LGEPEPIRSKLAneSALRTHLLALIASGFANSREELLDFLENTFYAYQY-------------DKGDLEEV 458
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720413921 318 LQElclkNLKDLSSLDLIKMDEDvNFKPTEAGRLMAWYYITFETVKKF----CAISGKETLLDLISMISSCNEFLD 389
Cdd:COG1204 459 VDD----ALEFLLENGFIEEDGD-RLRATKLGKLVSRLYIDPLTAAELvdglRKADEEFTDLGLLHLILILRDWIN 529
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
16-237 |
9.64e-32 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 133.53 E-value: 9.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 16 PVPVRFVAVSATIPNAEDIAEWLSD--GErpavCLKMDESHRPVKL-QKVVLG---FPCSSSQTEFKFDLALNYKVYSVI 89
Cdd:COG4581 162 PARVQLVLLSATVGNAEEFAEWLTRvrGE----TAVVVSEERPVPLeFHYLVTprlFPLFRVNPELLRPPSRHEVIEELD 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 90 RTysDQKPTLVFCSTRKGVQQAASVLVkdAKFIISVEQKLRL-------QKSAYSIRDSKLKDTLVYGVGYHHAGMELSD 162
Cdd:COG4581 238 RG--GLLPAIVFIFSRRGCDEAAQQLL--SARLTTKEERAEIreaidefAEDFSVLFGKTLSRLLRRGIAVHHAGMLPKY 313
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413921 163 RKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGRPQFDTTATAVIM 237
Cdd:COG4581 314 RRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAGRRGIDTEGHVVVL 388
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
22-365 |
5.87e-31 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 130.71 E-value: 5.87e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 22 VAVSATIPNAEDIAEWLSdgerpAVCLKMDesHRPVKLQKVV--LGFPCSSSQTEFKFDLALNYKVYSVIRTysdQKPTL 99
Cdd:PRK00254 173 LGLSATVGNAEELAEWLN-----AELVVSD--WRPVKLRKGVfyQGFLFWEDGKIERFPNSWESLVYDAVKK---GKGAL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 100 VFCSTRKGVQQAASVLVKDAKFIISVEQKLRLQKSAYSIRDS----KLKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDL 175
Cdd:PRK00254 243 VFVNTRRSAEKEALELAKKIKRFLTKPELRALKELADSLEENptneKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLI 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 176 PVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGRPQFDTTATAVIMTR------------LSTR 243
Cdd:PRK00254 323 KVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQMMGRAGRPKYDEVGEAIIVATteepsklmeryiFGKP 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 244 EKYVQMLACndtvESSLHRHLIehlnAEIVLHTITDVNIALDWIRSTmLYIRALKNPSHygfssglnkdgIEAKLQELCL 323
Cdd:PRK00254 403 EKLFSMLSN----ESAFRSQVL----ALITNFGVSNFKELVNFLERT-FYAHQRKDLYS-----------LEEKAKEIVY 462
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1720413921 324 KNLKDlsslDLIKMDEDVNFKPTEAGRLMAWYYITFETVKKF 365
Cdd:PRK00254 463 FLLEN----EFIDIDLEDRFIPLPLGIRTSQLYIDPLTAKKF 500
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
1-56 |
7.55e-17 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 80.09 E-value: 7.55e-17
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720413921 1 MKTVqSLSRDLESASPVPVRFVAVSATIPNAEDIAEWLSDGerPAVCLKMDESHRP 56
Cdd:cd18023 154 MKTL-SSSSELRGSTVRPMRFVAVSATIPNIEDLAEWLGDN--PAGCFSFGESFRP 206
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
149-226 |
2.88e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.08 E-value: 2.88e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720413921 149 YGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMP-AHLVVIKSTmhysggvfeEYSETDILQMIGRAGRP 226
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGRA 81
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
141-225 |
1.27e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 56.45 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 141 SKLKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMP-AHLVVIkstmhYSGgvfeEYSETDILQM 219
Cdd:pfam00271 31 ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN-----YDL----PWNPASYIQR 101
|
....*.
gi 1720413921 220 IGRAGR 225
Cdd:pfam00271 102 IGRAGR 107
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sec63 |
pfam02889 |
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of ... |
345-658 |
4.50e-69 |
|
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Pssm-ID: 460740 Cd Length: 307 Bit Score: 233.25 E-value: 4.50e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 345 PTEAGRLMAWYYITFETVKKFC-AISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKdpnriTIRFPMAERIKTR 423
Cdd:pfam02889 1 PTDLGRIASHYYISYETIETFNqSLKPNTTLADLLRILSSASEFEQIPVRQEEKKELKKLLE-----KVPIPVKGDIEDP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 424 EMKVNCLIQAQLGCIPIQDFALTQDTVKIFRNGSRIARWLSDfVAAQEKKFAVLLNSVILTKCFKCKLWeNSKHVSKQLD 503
Cdd:pfam02889 76 HAKVNILLQAYISRLKLPGFALVSDMNYILQNAGRILRALFE-ILLSKGWLSAALTALDLCKMIEQRMW-DSDSPLRQFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 504 KIGISLSNTMVNAGLTSFKKIEEANARELELILNRHPPFGTQIKEAVAHLPKYELEVEqIARYSDIKAEILVTIIlRNFE 583
Cdd:pfam02889 154 GIPPELIKKLEKKGVESVRDILELDDAEELGELIRNPKMGKDIAQFVNRFPKIEIEAE-VQPITRSVLRVEVTIT-PDFP 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720413921 584 qlQTKRTAPDFHYATLIIGDADNQVVFKHKIMdSVLLKSGNWVKKIDVKRALISE---DLSINLISSDYVGLDIHQKF 658
Cdd:pfam02889 232 --WDKRVHGKSEGFWLVVGDSDGNEILHIERF-TLTKRTLAGEHKLEFTVPPSDPgppQLFVRLISDSWLGADQEVPI 306
|
|
| Sec63 |
smart00973 |
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl ... |
345-660 |
8.33e-61 |
|
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Pssm-ID: 214946 Cd Length: 314 Bit Score: 210.29 E-value: 8.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 345 PTEAGRLMAWYYITFETVKKFCA-ISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKDpnritIRFPMAERIKTR 423
Cdd:smart00973 1 PTELGRIASYYYISYETIETFNQsLKPTTTLKDILEILSRASEFKEIPVRHNEKKELNELNKR-----VPIPVKEGIIDS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 424 EM-KVNCLIQAQLGCIPIQDFALTQDTVKIFRNGSRIARWLSDfVAAQEKKFAVLLNSVILTKCFKCKLWENSKHVSKQL 502
Cdd:smart00973 76 PHaKVNLLLQAHLSRLPLPDFDLVSDLKYILQNAPRILRALVD-IALSKGWLRTALNALDLSQMVVQRLWEDSDSPLKQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 503 DKIGIS--LSNTMVNAGLTSFKKIEEANARELELILNRHPPFGTQIKEAVAHLPKYELEVEQIARYSDIKAEILVTIIlr 580
Cdd:smart00973 155 PHFLIEdvYDKLELKDGSRSFELLLDMNAAELGEFLNRLPPNGRLIYELLRRFPKIEVEAEVLPITRDLTLRVELEIT-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 581 NFEQLQTKRTAPDFHYATLIIGDADNQVVFKHKIMDSVLLKSGNWVK-KIDVKR-ALISEDLSINLISSDYVGLDIHQKF 658
Cdd:smart00973 233 PVFAWDLPRHKGKSESWWLVVGDSDTNELLAIKRVTLRKKKKSNEVKlDFTVPLsEPGPENYTVYLISDSYLGCDQEVSF 312
|
..
gi 1720413921 659 TV 660
Cdd:smart00973 313 SL 314
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
55-239 |
2.27e-60 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 203.17 E-value: 2.27e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 55 RPVKLQKVVLGFPCSSSQTEFKFDL--ALNYKVYSVIRTYSDQKPTLVFCSTRKGVQQAASVLVkdakfiisveqklrlq 132
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNkfDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLA---------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 133 ksaysirdsklkdtlvyGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYS 212
Cdd:cd18795 65 -----------------GIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELS 127
|
170 180
....*....|....*....|....*..
gi 1720413921 213 ETDILQMIGRAGRPQFDTTATAVIMTR 239
Cdd:cd18795 128 PLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
18-389 |
2.51e-55 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 201.28 E-value: 2.51e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 18 PVRFVAVSATIPNAEDIAEWLsdgERPAVclkmDESHRPVKLQKVV-----LGFPCSSSQTEFKFdLALnykvysVIRTY 92
Cdd:COG1204 171 EAQIVALSATIGNAEEIAEWL---DAELV----KSDWRPVPLNEGVlydgvLRFDDGSRRSKDPT-LAL------ALDLL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 93 SDQKPTLVFCSTRKGVQQAASVLVKDAKFIISVEQKLRLQKSAYSIR--------DSKLKDTLVYGVGYHHAGMELSDRK 164
Cdd:COG1204 237 EEGGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREELEELAEELLevseethtNEKLADCLEKGVAFHHAGLPSELRR 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 165 LVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTmHYSGGVfeEYSETDILQMIGRAGRPQFDTTATAVIMTRLST-- 242
Cdd:COG1204 317 LVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDT-KRGGMV--PIPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDea 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 243 ---REKYVqmLACNDTVESSLH--RHLIEHLNAEIVLHTITDVNIALDWIRSTMLYIRAlknpshygfssglNKDGIEAK 317
Cdd:COG1204 394 delFERYI--LGEPEPIRSKLAneSALRTHLLALIASGFANSREELLDFLENTFYAYQY-------------DKGDLEEV 458
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720413921 318 LQElclkNLKDLSSLDLIKMDEDvNFKPTEAGRLMAWYYITFETVKKF----CAISGKETLLDLISMISSCNEFLD 389
Cdd:COG1204 459 VDD----ALEFLLENGFIEEDGD-RLRATKLGKLVSRLYIDPLTAAELvdglRKADEEFTDLGLLHLILILRDWIN 529
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
16-237 |
9.64e-32 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 133.53 E-value: 9.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 16 PVPVRFVAVSATIPNAEDIAEWLSD--GErpavCLKMDESHRPVKL-QKVVLG---FPCSSSQTEFKFDLALNYKVYSVI 89
Cdd:COG4581 162 PARVQLVLLSATVGNAEEFAEWLTRvrGE----TAVVVSEERPVPLeFHYLVTprlFPLFRVNPELLRPPSRHEVIEELD 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 90 RTysDQKPTLVFCSTRKGVQQAASVLVkdAKFIISVEQKLRL-------QKSAYSIRDSKLKDTLVYGVGYHHAGMELSD 162
Cdd:COG4581 238 RG--GLLPAIVFIFSRRGCDEAAQQLL--SARLTTKEERAEIreaidefAEDFSVLFGKTLSRLLRRGIAVHHAGMLPKY 313
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413921 163 RKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGRPQFDTTATAVIM 237
Cdd:COG4581 314 RRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAGRRGIDTEGHVVVL 388
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
22-365 |
5.87e-31 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 130.71 E-value: 5.87e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 22 VAVSATIPNAEDIAEWLSdgerpAVCLKMDesHRPVKLQKVV--LGFPCSSSQTEFKFDLALNYKVYSVIRTysdQKPTL 99
Cdd:PRK00254 173 LGLSATVGNAEELAEWLN-----AELVVSD--WRPVKLRKGVfyQGFLFWEDGKIERFPNSWESLVYDAVKK---GKGAL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 100 VFCSTRKGVQQAASVLVKDAKFIISVEQKLRLQKSAYSIRDS----KLKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDL 175
Cdd:PRK00254 243 VFVNTRRSAEKEALELAKKIKRFLTKPELRALKELADSLEENptneKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLI 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 176 PVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGRPQFDTTATAVIMTR------------LSTR 243
Cdd:PRK00254 323 KVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQMMGRAGRPKYDEVGEAIIVATteepsklmeryiFGKP 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 244 EKYVQMLACndtvESSLHRHLIehlnAEIVLHTITDVNIALDWIRSTmLYIRALKNPSHygfssglnkdgIEAKLQELCL 323
Cdd:PRK00254 403 EKLFSMLSN----ESAFRSQVL----ALITNFGVSNFKELVNFLERT-FYAHQRKDLYS-----------LEEKAKEIVY 462
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1720413921 324 KNLKDlsslDLIKMDEDVNFKPTEAGRLMAWYYITFETVKKF 365
Cdd:PRK00254 463 FLLEN----EFIDIDLEDRFIPLPLGIRTSQLYIDPLTAKKF 500
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
22-237 |
3.39e-26 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 115.83 E-value: 3.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 22 VAVSATIPNAEDIAEWLsDGERpavclkMDESHRPVKLQKVVL---GFPCSSSQTEFKF-----DLALnykvysVIRTYS 93
Cdd:PRK02362 175 VALSATIGNADELADWL-DAEL------VDSEWRPIDLREGVFyggAIHFDDSQREVEVpskddTLNL------VLDTLE 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 94 DQKPTLVFCSTRKGVQQAASVLVKDAKFIISVEQKLRLQKSAYSIRDS-------KLKDTLVYGVGYHHAGMELSDRKLV 166
Cdd:PRK02362 242 EGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAELAELAEEIREVsdtetskDLADCVAKGAAFHHAGLSREHRELV 321
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720413921 167 EGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGG-------VFeEYSetdilQMIGRAGRPQFDTTATAVIM 237
Cdd:PRK02362 322 EDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGagmqpipVL-EYH-----QMAGRAGRPGLDPYGEAVLL 393
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
19-361 |
6.76e-26 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 114.60 E-value: 6.76e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 19 VRFVAVSATIPNAEDIAEWLSdgerpAVCLKmdESHRPVKLQKVVLGFPCSSSQTEFKFDLALNykvySVIR-TYSDQKP 97
Cdd:PRK01172 170 ARILALSATVSNANELAQWLN-----ASLIK--SNFRPVPLKLGILYRKRLILDGYERSQVDIN----SLIKeTVNDGGQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 98 TLVFCSTRKGVQQAASVLVK----DAKFIISVEQKlrlqksaySIRDSKLKDTLVYGVGYHHAGMELSDRKLVEGLFTSG 173
Cdd:PRK01172 239 VLVFVSSRKNAEDYAEMLIQhfpeFNDFKVSSENN--------NVYDDSLNEMLPHGVAFHHAGLSNEQRRFIEEMFRNR 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 174 DLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGRPQFDTTATAVImtrlstrekYVQMLACN 253
Cdd:PRK01172 311 YIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYGIGYI---------YAASPASY 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 254 DTVESSLHRH---LIEHLNAEIVLHTITDVNIALDWIRStMLYIRALKNPSHYGFSSGlnKDGIEAKLQElclkNLKDLS 330
Cdd:PRK01172 382 DAAKKYLSGEpepVISYMGSQRKVRFNTLAAISMGLASS-MEDLILFYNETLMAIQNG--VDEIDYYIES----SLKFLK 454
|
330 340 350
....*....|....*....|....*....|.
gi 1720413921 331 SLDLIKmdEDVNFKPTEAGRLMAWYYITFET 361
Cdd:PRK01172 455 ENGFIK--GDVTLRATRLGKLTSDLYIDPES 483
|
|
| SEC63 |
smart00611 |
Domain of unknown function in Sec63p, Brr2p and other proteins; |
343-563 |
2.94e-18 |
|
Domain of unknown function in Sec63p, Brr2p and other proteins;
Pssm-ID: 214744 Cd Length: 312 Bit Score: 86.93 E-value: 2.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 343 FKPTEAGRLMAWYYITFETVKKFC-AISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKDpNRITIRFPMAERIK 421
Cdd:smart00611 2 IWPTDLGRIASYYYISYTTIRTFNeLLKPKMTTKDLLRILSMSSEFDQIPVRHEEDLLLEELAEK-LPIRLENPSLDDPH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 422 TremKVNCLIQAQLGCIPIQDFALTQDTVKIFRNGSRIARWLSDfVAAQEKKFAVLLNSVILTKCFKCKLWEnSKHVSKQ 501
Cdd:smart00611 81 V---KANLLLQAHLSRLKLPSFALESDTVYVLQNAGRLLQAMVD-IALERGWLSTALNALNLSQMIIQALWP-TDSPLLQ 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720413921 502 LDKIGISLSNTMVNAGLTSFKKIEEANARELELILNRHPPFGTQIKEAVAHLPKYELEVEQI 563
Cdd:smart00611 156 LPHLPEEILKRLEKKKVLSLEDLLELEDEERGELLGLLDAEGERVYKVLSRLPKLNIEISLE 217
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
1-56 |
7.55e-17 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 80.09 E-value: 7.55e-17
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720413921 1 MKTVqSLSRDLESASPVPVRFVAVSATIPNAEDIAEWLSDGerPAVCLKMDESHRP 56
Cdd:cd18023 154 MKTL-SSSSELRGSTVRPMRFVAVSATIPNIEDLAEWLGDN--PAGCFSFGESFRP 206
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
149-226 |
2.88e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.08 E-value: 2.88e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720413921 149 YGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMP-AHLVVIKSTmhysggvfeEYSETDILQMIGRAGRP 226
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGRA 81
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
130-228 |
2.96e-10 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 64.53 E-value: 2.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 130 RLQKSAYSIRDSK------------------LKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMP 191
Cdd:COG1202 412 KLVKREFDTKSSKgyrgqtiiftnsrrrcheIARALGYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFP 491
|
90 100 110
....*....|....*....|....*....|....*...
gi 1720413921 192 AHLVVIKS-TMhysGGvfEEYSETDILQMIGRAGRPQF 228
Cdd:COG1202 492 ASQVIFDSlAM---GI--EWLSVQEFHQMLGRAGRPDY 524
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
141-225 |
1.27e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 56.45 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 141 SKLKDTLVYGVGYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMP-AHLVVIkstmhYSGgvfeEYSETDILQM 219
Cdd:pfam00271 31 ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN-----YDL----PWNPASYIQR 101
|
....*.
gi 1720413921 220 IGRAGR 225
Cdd:pfam00271 102 IGRAGR 107
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
14-225 |
2.19e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 51.76 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 14 ASPVpvrFVAVSATIPNAEDIAEWLSDgeRPAVCLkmDESHRPVKLQKVVLGFPC-------SSSQTEFKfDLALNYkvy 86
Cdd:COG1205 216 SDPQ---FILASATIGNPAEHAERLTG--RPVTVV--DEDGSPRGERTFVLWNPPlvddgirRSALAEAA-RLLADL--- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 87 svirTYSDQKpTLVFCSTRKGVQQAASVLvkdakfiisveqKLRLQKSAYSIRdsklkdtlvygVGYHHAGMELSDRKLV 166
Cdd:COG1205 285 ----VREGLR-TLVFTRSRRGAELLARYA------------RRALREPDLADR-----------VAAYRAGYLPEERREI 336
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 167 EGLFTSGDLPVLFTTSTLAMGMNMPA-HLVVIkstMHYSGGVfeeyseTDILQMIGRAGR 225
Cdd:COG1205 337 ERGLRSGELLGVVSTNALELGIDIGGlDAVVL---AGYPGTR------ASFWQQAGRAGR 387
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
86-225 |
1.15e-05 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 48.98 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 86 YSVIRTYSDQK--------------PTLVFCSTRKGVQQAASvlvkdakfiisveqklRLQKSAYSirdsklkdtlvygV 151
Cdd:COG0514 207 LEVVPKPPDDKlaqlldflkehpggSGIVYCLSRKKVEELAE----------------WLREAGIR-------------A 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 152 GYHHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMG-----------MNMPAHLvvikstmhysggvfEEYsetdiLQMI 220
Cdd:COG0514 258 AAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGidkpdvrfvihYDLPKSI--------------EAY-----YQEI 318
|
....*
gi 1720413921 221 GRAGR 225
Cdd:COG0514 319 GRAGR 323
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
73-225 |
2.61e-05 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 44.89 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 73 TEFKFDLALNYKVYSvirtysDQKPTLVFCSTRKGVQQAASVLvkdakfiisveQKLRLQKSAYsirdsklkdtlvygvg 152
Cdd:cd18794 14 KDEKLDLLKRIKVEH------LGGSGIIYCLSRKECEQVAARL-----------QSKGISAAAY---------------- 60
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720413921 153 yhHAGMELSDRKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIkstmHYS-GGVFEEYsetdiLQMIGRAGR 225
Cdd:cd18794 61 --HAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVI----HYSlPKSMESY-----YQESGRAGR 123
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
3-42 |
1.05e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 44.17 E-value: 1.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1720413921 3 TVQSLSRDLESASPvPVRFVAVSATIPNAEDIAEWLSDGE 42
Cdd:cd17921 138 VLELLLSRLLRINK-NARFVGLSATLPNAEDLAEWLGVED 176
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
169-225 |
8.96e-04 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 40.62 E-value: 8.96e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1720413921 169 LFTSGDLP--VLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSETDILQMIGRAGR 225
Cdd:cd18805 63 LFNDPESGydVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGR 121
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
88-225 |
1.88e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 42.01 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 88 VIRTYSDQ--KPTLVFCSTRKGVQQAASvlvkdakfiisveqklRLQKSAYSirdsklkdtlvygVGYHHAGMELSDRKL 165
Cdd:PRK11057 227 LMRYVQEQrgKSGIIYCNSRAKVEDTAA----------------RLQSRGIS-------------AAAYHAGLDNDVRAD 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413921 166 VEGLFTSGDLPVLFTTSTLAMGMNMP-----AHLVVIKSTMHYsggvfeeYSETdilqmiGRAGR 225
Cdd:PRK11057 278 VQEAFQRDDLQIVVATVAFGMGINKPnvrfvVHFDIPRNIESY-------YQET------GRAGR 329
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
98-225 |
2.07e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 39.55 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 98 TLVFCSTRKgvqqAASVLVKDAKFIISVEQKLrlqksaysirdsklkdtlVYGVGYHHAGMELSDRKLVEGLFTSGDLPV 177
Cdd:cd18797 38 TIVFCRSRK----LAELLLRYLKARLVEEGPL------------------ASKVASYRAGYLAEDRREIEAELFNGELLG 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1720413921 178 LFTTSTLAMGMNMPAHLVVIKSTmhYSGGVFEeysetdILQMIGRAGR 225
Cdd:cd18797 96 VVATNALELGIDIGGLDAVVLAG--YPGSLAS------LWQQAGRAGR 135
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
98-225 |
3.23e-03 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 39.17 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413921 98 TLVFCSTRKGVQqaasvlvkdakfiiSVEQKLRLqksaysiRDSKLKDTLVYGVgyHHAGMELSDRKLVEGLFTSGDLPV 177
Cdd:cd18796 41 TLVFTNTRSQAE--------------RLAQRLRE-------LCPDRVPPDFIAL--HHGSLSRELREEVEAALKRGDLKV 97
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90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1720413921 178 LFTTSTLAMGMNMPA-HLVV-IKSTmhysggvfeeYSETDILQMIGRAGR 225
Cdd:cd18796 98 VVATSSLELGIDIGDvDLVIqIGSP----------KSVARLLQRLGRSGH 137
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| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
16-39 |
5.65e-03 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 39.35 E-value: 5.65e-03
10 20
....*....|....*....|....
gi 1720413921 16 PVPVRFVAVSATIPNAEDIAEWLS 39
Cdd:cd18024 167 PDKVRYVFLSATIPNARQFAEWIC 190
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| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
19-38 |
8.40e-03 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 38.47 E-value: 8.40e-03
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