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Conserved domains on  [gi|1720361566|ref|XP_030100991|]
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probable methyltransferase-like protein 24 isoform X5 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 51-101 3.92e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member TIGR01444:

Pssm-ID: 473071  Cd Length: 143  Bit Score: 44.22  E-value: 3.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720361566  51 TRKLGSILNEFGHHKIDVLKADLESAEWKVLENLIlEDVLEQIGQLVFEIH 101
Cdd:TIGR01444  94 VVTLDDLVEEFGLDKVDLLKIDVEGAELEVLRGAA-ETLLEKRPVIVLEVH 143
 
Name Accession Description Interval E-value
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 51-101 3.92e-06

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 44.22  E-value: 3.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720361566  51 TRKLGSILNEFGHHKIDVLKADLESAEWKVLENLIlEDVLEQIGQLVFEIH 101
Cdd:TIGR01444  94 VVTLDDLVEEFGLDKVDLLKIDVEGAELEVLRGAA-ETLLEKRPVIVLEVH 143
Methyltransf_22 pfam13383
Methyltransferase domain; This family appears to be a methyltransferase domain.
 1-101 7.72e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 372586  Cd Length: 252  Bit Score: 38.48  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361566   1 MANGGCEVHRFDPSVKSAHVLERQGLWHHRLSIDWRDPHPAVAAQKPHGNTRKLGSILNEFGH--HKIDVLKADLESAEW 78
Cdd:pfam13383 109 LGSDHCEIHVFDFGNFARSVNKEKNIHYHQWGLGSSYDNVYNPTMGNKGEILTFQDTQKLLGHklRTIDVFKIDCEKCEW 188

                          90       100
                  ....*....|....*....|...
gi 1720361566  79 KVLENLILEDvleqIGQLVFEIH 101
Cdd:pfam13383 189 ENYKDWVAVD----IRQILVEVH 207
 
Name Accession Description Interval E-value
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 51-101 3.92e-06

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 44.22  E-value: 3.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720361566  51 TRKLGSILNEFGHHKIDVLKADLESAEWKVLENLIlEDVLEQIGQLVFEIH 101
Cdd:TIGR01444  94 VVTLDDLVEEFGLDKVDLLKIDVEGAELEVLRGAA-ETLLEKRPVIVLEVH 143
Methyltransf_22 pfam13383
Methyltransferase domain; This family appears to be a methyltransferase domain.
 1-101 7.72e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 372586  Cd Length: 252  Bit Score: 38.48  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361566   1 MANGGCEVHRFDPSVKSAHVLERQGLWHHRLSIDWRDPHPAVAAQKPHGNTRKLGSILNEFGH--HKIDVLKADLESAEW 78
Cdd:pfam13383 109 LGSDHCEIHVFDFGNFARSVNKEKNIHYHQWGLGSSYDNVYNPTMGNKGEILTFQDTQKLLGHklRTIDVFKIDCEKCEW 188

                          90       100
                  ....*....|....*....|...
gi 1720361566  79 KVLENLILEDvleqIGQLVFEIH 101
Cdd:pfam13383 189 ENYKDWVAVD----IRQILVEVH 207
Methyltransf_21 pfam05050
Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to ...
 51-113 2.96e-03

Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to be a methyltransferase.


Pssm-ID: 428282  Cd Length: 170  Bit Score: 36.39  E-value: 2.96e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720361566  51 TRKLGSILNEFGHHKIDVLKADLESAEWKVLENliLEDVLE--QIGQLVFEIHLHWPGFEVSGSE 113
Cdd:pfam05050  96 TVTLDSFLEEIKKSDIDLLKIDVEGAELEVLEG--AEKTLKrcQPNIIVIEVHFFHYFGGPLFDE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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